Degradation of MyoD by the ubiquitin pathway: regulation by specific DNA-binding and identification of a novel site for ubiquitination

MyoD is a tissue-specific transcriptional activator involvd in skeletal muscle differentiation. It is induced during transition from proliferating, non-differentiated myoblasts to the resting and well differentiated myotubes. Like many other transcriptional regulators, it is short-lived, however, th...

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Veröffentlicht in:	Molecular biology reports 1999-04, Vol.26 (1-2), p.59-64
Hauptverfasser:	Ciechanover, A, Breitschopf, K, Hatoum, O A, Bengal, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism ATP DNA - metabolism lactacystin MyoD protein MyoD Protein - metabolism Nucleotide sequence Protein Binding Proteins Proteolysis Skeletal muscle Transcription Ubiquitin ubiquitination Ubiquitins - metabolism
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