ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

Nijmegen breakage syndrome (NBS) is characterized by extreme radiation sensitivity, chromosomal instability and cancer 1 . The phenotypes are similar to those of ataxia telangiectasia mutated (ATM) disease, where there is a deficiency in a protein kinase that is activated by DNA damage, indicating t...

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Veröffentlicht in:	Nature (London) 2000-05, Vol.405 (6785), p.477-482
Hauptverfasser:	Wu, Xiaohua, Ranganathan, Velvizhi, Weisman, David S., Heine, Walter F., Ciccone, David N., O'Neill, Ted B., Crick, Kindra E., Pierce, Kerry A., Lane, William S., Rathbun, Gary, Livingston, David M., Weaver, David T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ataxia Telangiectasia - genetics Ataxia Telangiectasia Mutated Proteins ATM protein Biological and medical sciences Cancer Catalysis Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Cycle Proteins - physiology Cell Line Chromosome Breakage Chromosome fragility (bloom syndrome, ataxia telangiectasia, fanconi anemia, x-linked mental retardation...) Deoxyribonucleic acid DNA DNA Damage DNA-Binding Proteins Gamma Rays Genes Humanities and Social Sciences Humans Inactivation letter Medical disorders Medical genetics Medical sciences multidisciplinary NBS protein Neoplasms - genetics Nijmegen breakage syndrome Nuclear Proteins Phosphorylation Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Protein-Serine-Threonine Kinases - physiology Proteins Radiation Tolerance - genetics Science Science (multidisciplinary) Serine - metabolism Syndrome Tumor Suppressor Proteins Ultraviolet radiation
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