Celiac sprue: another autoimmune syndrome associated with hepatitis C
Celiac sprue is being diagnosed with increasing frequency by screening individuals with epidemiologically associated autoimmune syndromes. We sought to test our hypothesis that hepatitis C also may predispose to celiac sprue because it can trigger autoimmune reactions. Two hundred fifty-nine consecu...
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| Veröffentlicht in: | The American journal of gastroenterology 2001-01, Vol.96 (1), p.138-145 |
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| creator | Fine, Kenneth D Ogunji, Frederick Saloum, Yasser Beharry, Shari Crippin, Jeffrey Weinstein, Jeffrey |
| description | Celiac sprue is being diagnosed with increasing frequency by screening individuals with epidemiologically associated autoimmune syndromes. We sought to test our hypothesis that hepatitis C also may predispose to celiac sprue because it can trigger autoimmune reactions. Two hundred fifty-nine consecutively evaluated patients with chronic hepatitis C infection, 59 with autoimmune liver disease, 137 with other hepatic diseases, 356 with various GI syndromes, and 221 normal volunteers underwent serologic screening for celiac sprue. Patients with antigliadin, antiendomysial, and antitissue transglutaminase antibodies in serum underwent duodenoscopy and biopsy. There was a statistically significantly higher prevalence of antigliadin antibody in all groups of patients with liver disease compared with GI controls and normal controls. However, only patients with hepatitis C (n = 3; 1.2%) or autoimmune liver disease (n = 2; 3.4%) had antiendomysial/antitissue transglutaminase antibody in serum. One of 221 normal volunteers (0.4%) was antigliadin, antiendomysial, and antitissue transglutaminase positive; this individual also was found to have hepatitis C (previously undiagnosed). Each of these six individuals had mild intestinal symptoms, duodenal histopathology consistent with celiac sprue, and the celiac-associated HLA-DQ2 allele. Five of the six followed a prescribed gluten-free diet and experienced symptomatic improvement. Celiac sprue is epidemiologically associated with chronic hepatitis C infection and with autoimmune liver disease. Because hepatitis C is much more frequently encountered than autoimmune liver disease, hepatitis C appears to be the most common hepatic disease associated with the development of celiac sprue. |
| doi_str_mv | 10.1111/j.1572-0241.2001.03464.x |
| format | Article |
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We sought to test our hypothesis that hepatitis C also may predispose to celiac sprue because it can trigger autoimmune reactions. Two hundred fifty-nine consecutively evaluated patients with chronic hepatitis C infection, 59 with autoimmune liver disease, 137 with other hepatic diseases, 356 with various GI syndromes, and 221 normal volunteers underwent serologic screening for celiac sprue. Patients with antigliadin, antiendomysial, and antitissue transglutaminase antibodies in serum underwent duodenoscopy and biopsy. There was a statistically significantly higher prevalence of antigliadin antibody in all groups of patients with liver disease compared with GI controls and normal controls. However, only patients with hepatitis C (n = 3; 1.2%) or autoimmune liver disease (n = 2; 3.4%) had antiendomysial/antitissue transglutaminase antibody in serum. One of 221 normal volunteers (0.4%) was antigliadin, antiendomysial, and antitissue transglutaminase positive; this individual also was found to have hepatitis C (previously undiagnosed). Each of these six individuals had mild intestinal symptoms, duodenal histopathology consistent with celiac sprue, and the celiac-associated HLA-DQ2 allele. Five of the six followed a prescribed gluten-free diet and experienced symptomatic improvement. Celiac sprue is epidemiologically associated with chronic hepatitis C infection and with autoimmune liver disease. Because hepatitis C is much more frequently encountered than autoimmune liver disease, hepatitis C appears to be the most common hepatic disease associated with the development of celiac sprue.</description><identifier>ISSN: 0002-9270</identifier><identifier>EISSN: 1572-0241</identifier><identifier>DOI: 10.1111/j.1572-0241.2001.03464.x</identifier><identifier>PMID: 11197243</identifier><language>eng</language><publisher>Oxford: .</publisher><subject>Adult ; Aged ; Autoimmune Diseases - epidemiology ; Autoimmune Diseases - immunology ; Biological and medical sciences ; Biopsy, Needle ; Case-Control Studies ; Celiac Disease - diagnosis ; Celiac Disease - epidemiology ; Celiac Disease - immunology ; Chi-Square Distribution ; Cohort Studies ; Comorbidity ; Female ; Gastroenterology ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatitis C ; Hepatitis C, Chronic - epidemiology ; Hepatitis C, Chronic - immunology ; Humans ; Liver Cirrhosis - epidemiology ; Liver Cirrhosis - immunology ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Prevalence ; Probability ; Prognosis ; Risk Assessment ; Risk Factors ; Serologic Tests ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Syndrome</subject><ispartof>The American journal of gastroenterology, 2001-01, Vol.96 (1), p.138-145</ispartof><rights>All Rights Reserved.</rights><rights>2001 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jan 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3154-6a43280fc9fd0de998b7699de354e49ea49b3f2a12243c2ed9d9d29f1f6b92533</citedby><cites>FETCH-LOGICAL-c3154-6a43280fc9fd0de998b7699de354e49ea49b3f2a12243c2ed9d9d29f1f6b92533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,4012,27910,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=855494$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11197243$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fine, Kenneth D</creatorcontrib><creatorcontrib>Ogunji, Frederick</creatorcontrib><creatorcontrib>Saloum, Yasser</creatorcontrib><creatorcontrib>Beharry, Shari</creatorcontrib><creatorcontrib>Crippin, Jeffrey</creatorcontrib><creatorcontrib>Weinstein, Jeffrey</creatorcontrib><title>Celiac sprue: another autoimmune syndrome associated with hepatitis C</title><title>The American journal of gastroenterology</title><addtitle>Am J Gastroenterol</addtitle><description>Celiac sprue is being diagnosed with increasing frequency by screening individuals with epidemiologically associated autoimmune syndromes. We sought to test our hypothesis that hepatitis C also may predispose to celiac sprue because it can trigger autoimmune reactions. Two hundred fifty-nine consecutively evaluated patients with chronic hepatitis C infection, 59 with autoimmune liver disease, 137 with other hepatic diseases, 356 with various GI syndromes, and 221 normal volunteers underwent serologic screening for celiac sprue. Patients with antigliadin, antiendomysial, and antitissue transglutaminase antibodies in serum underwent duodenoscopy and biopsy. There was a statistically significantly higher prevalence of antigliadin antibody in all groups of patients with liver disease compared with GI controls and normal controls. However, only patients with hepatitis C (n = 3; 1.2%) or autoimmune liver disease (n = 2; 3.4%) had antiendomysial/antitissue transglutaminase antibody in serum. One of 221 normal volunteers (0.4%) was antigliadin, antiendomysial, and antitissue transglutaminase positive; this individual also was found to have hepatitis C (previously undiagnosed). Each of these six individuals had mild intestinal symptoms, duodenal histopathology consistent with celiac sprue, and the celiac-associated HLA-DQ2 allele. Five of the six followed a prescribed gluten-free diet and experienced symptomatic improvement. Celiac sprue is epidemiologically associated with chronic hepatitis C infection and with autoimmune liver disease. Because hepatitis C is much more frequently encountered than autoimmune liver disease, hepatitis C appears to be the most common hepatic disease associated with the development of celiac sprue.</description><subject>Adult</subject><subject>Aged</subject><subject>Autoimmune Diseases - epidemiology</subject><subject>Autoimmune Diseases - immunology</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Needle</subject><subject>Case-Control Studies</subject><subject>Celiac Disease - diagnosis</subject><subject>Celiac Disease - epidemiology</subject><subject>Celiac Disease - immunology</subject><subject>Chi-Square Distribution</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatitis C</subject><subject>Hepatitis C, Chronic - epidemiology</subject><subject>Hepatitis C, Chronic - immunology</subject><subject>Humans</subject><subject>Liver Cirrhosis - epidemiology</subject><subject>Liver Cirrhosis - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Prevalence</subject><subject>Probability</subject><subject>Prognosis</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Serologic Tests</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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Liver. Pancreas. Abdomen</topic><topic>Hepatitis C</topic><topic>Hepatitis C, Chronic - epidemiology</topic><topic>Hepatitis C, Chronic - immunology</topic><topic>Humans</topic><topic>Liver Cirrhosis - epidemiology</topic><topic>Liver Cirrhosis - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Prevalence</topic><topic>Probability</topic><topic>Prognosis</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Serologic Tests</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. 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We sought to test our hypothesis that hepatitis C also may predispose to celiac sprue because it can trigger autoimmune reactions. Two hundred fifty-nine consecutively evaluated patients with chronic hepatitis C infection, 59 with autoimmune liver disease, 137 with other hepatic diseases, 356 with various GI syndromes, and 221 normal volunteers underwent serologic screening for celiac sprue. Patients with antigliadin, antiendomysial, and antitissue transglutaminase antibodies in serum underwent duodenoscopy and biopsy. There was a statistically significantly higher prevalence of antigliadin antibody in all groups of patients with liver disease compared with GI controls and normal controls. However, only patients with hepatitis C (n = 3; 1.2%) or autoimmune liver disease (n = 2; 3.4%) had antiendomysial/antitissue transglutaminase antibody in serum. One of 221 normal volunteers (0.4%) was antigliadin, antiendomysial, and antitissue transglutaminase positive; this individual also was found to have hepatitis C (previously undiagnosed). Each of these six individuals had mild intestinal symptoms, duodenal histopathology consistent with celiac sprue, and the celiac-associated HLA-DQ2 allele. Five of the six followed a prescribed gluten-free diet and experienced symptomatic improvement. Celiac sprue is epidemiologically associated with chronic hepatitis C infection and with autoimmune liver disease. Because hepatitis C is much more frequently encountered than autoimmune liver disease, hepatitis C appears to be the most common hepatic disease associated with the development of celiac sprue.</abstract><cop>Oxford</cop><pub>.</pub><pmid>11197243</pmid><doi>10.1111/j.1572-0241.2001.03464.x</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Autoimmune Diseases - epidemiology Autoimmune Diseases - immunology Biological and medical sciences Biopsy, Needle Case-Control Studies Celiac Disease - diagnosis Celiac Disease - epidemiology Celiac Disease - immunology Chi-Square Distribution Cohort Studies Comorbidity Female Gastroenterology Gastroenterology. Liver. Pancreas. Abdomen Hepatitis C Hepatitis C, Chronic - epidemiology Hepatitis C, Chronic - immunology Humans Liver Cirrhosis - epidemiology Liver Cirrhosis - immunology Male Medical sciences Middle Aged Other diseases. Semiology Prevalence Probability Prognosis Risk Assessment Risk Factors Serologic Tests Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Syndrome |
| title | Celiac sprue: another autoimmune syndrome associated with hepatitis C |
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