Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture–on-chip (4C)

The spatial organization of DNA in the cell nucleus is an emerging key contributor to genomic function 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 . We developed 4C technology (chromosome conformation capture (3C)-on-chip), which allows for an unbiased genome-wide search for DNA loci that conta...

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Veröffentlicht in:	Nature genetics 2006-11, Vol.38 (11), p.1348-1354
Hauptverfasser:	Simonis, Marieke, Klous, Petra, Splinter, Erik, Moshkin, Yuri, Willemsen, Rob, de Wit, Elzo, van Steensel, Bas, de Laat, Wouter
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animal Genetics and Genomics Animals Biological and medical sciences Biomedical and Life Sciences Biomedicine Brain - cytology Brain - embryology Cancer Research Cell Nucleus - chemistry Cellular biology Chromatin Chromatin - chemistry Chromatin Assembly and Disassembly Chromatin. Chromosome Chromosome Mapping - methods Chromosomes Chromosomes, Mammalian - chemistry Deoxyribonucleic acid DNA DNA microarrays DNA-Binding Proteins - genetics Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation Gene Function Genetics of eukaryotes. Biological and molecular evolution Genomics Globins - genetics Human Genetics In Situ Hybridization, Fluorescence - methods letter Liver - cytology Liver - embryology Methods Mice Models, Biological Molecular and cellular biology Molecular genetics Nucleic Acid Conformation Oligonucleotide Array Sequence Analysis - methods Physiological aspects
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