Short term effects of reduced exposure to cigarette smoke on white blood cells, platelets and red blood cells in adult cigarette smokers
Previous studies indicate that cigarette smokers have a 5–30% higher white blood cell counts (WBC) compared to non-smokers and higher red blood cell counts. Methods: This study was to pool hematology data from three similar studies and analyze the data for effects on WBC, its subpopulations, platele...
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| Veröffentlicht in: | Regulatory toxicology and pharmacology 2010-07, Vol.57 (2-3), p.333-337 |
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| creator | Roethig, Hans J. Koval, Tamara Muhammad-Kah, Raheema Jin, Yan Mendes, Paul Unverdorben, Martin |
| description | Previous studies indicate that cigarette smokers have a 5–30% higher white blood cell counts (WBC) compared to non-smokers and higher red blood cell counts. Methods: This study was to pool hematology data from three similar studies and analyze the data for effects on WBC, its subpopulations, platelets, red blood cell count (RBC) and hematocrit in adult cigarette smokers three days after using an electrically heated cigarette smoking system (EHCSS) as a potential reduced exposure product (PREP) or no-smoking compared to smoking a conventional cigarette. Results: Lower exposure to cigarette smoke in adult, long term smokers, by using an EHCSS or stopping smoking, leads to statistically significant decreases of up to 9% in WBC, neutrophils, lymphocytes, platelets, RBC and hematocrit within three days. Switching from CC-smoking to EHCSS-smoking or no-smoking resulted in lower WBC and vice versa within 3days. Conclusion: This clinical model may be used as a screening tool to find new technologies that could provide insights on changes in inflammation resulting from the change in cigarette smoke. |
| doi_str_mv | 10.1016/j.yrtph.2010.04.005 |
| format | Article |
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Methods: This study was to pool hematology data from three similar studies and analyze the data for effects on WBC, its subpopulations, platelets, red blood cell count (RBC) and hematocrit in adult cigarette smokers three days after using an electrically heated cigarette smoking system (EHCSS) as a potential reduced exposure product (PREP) or no-smoking compared to smoking a conventional cigarette. Results: Lower exposure to cigarette smoke in adult, long term smokers, by using an EHCSS or stopping smoking, leads to statistically significant decreases of up to 9% in WBC, neutrophils, lymphocytes, platelets, RBC and hematocrit within three days. Switching from CC-smoking to EHCSS-smoking or no-smoking resulted in lower WBC and vice versa within 3days. Conclusion: This clinical model may be used as a screening tool to find new technologies that could provide insights on changes in inflammation resulting from the change in cigarette smoke.</description><identifier>ISSN: 0273-2300</identifier><identifier>EISSN: 1096-0295</identifier><identifier>DOI: 10.1016/j.yrtph.2010.04.005</identifier><identifier>PMID: 20394790</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Adult ; Blood Platelets - cytology ; Blood Platelets - drug effects ; Cigarettes smoke exposure ; Cross-Over Studies ; Erythrocyte Count ; Hematocrit ; Humans ; Inflammation ; Leukocyte Count ; Leukocytes - cytology ; Leukocytes - drug effects ; Male ; Middle Aged ; Nicotine - blood ; Platelet Count ; Platelets ; Red blood cells ; Reduced exposure ; Smoking ; Smoking - adverse effects ; Smoking - blood ; Smoking Cessation - methods ; White blood cells</subject><ispartof>Regulatory toxicology and pharmacology, 2010-07, Vol.57 (2-3), p.333-337</ispartof><rights>2010 Elsevier Inc.</rights><rights>Copyright 2010 Elsevier Inc. 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Conclusion: This clinical model may be used as a screening tool to find new technologies that could provide insights on changes in inflammation resulting from the change in cigarette smoke.</description><subject>Adult</subject><subject>Blood Platelets - cytology</subject><subject>Blood Platelets - drug effects</subject><subject>Cigarettes smoke exposure</subject><subject>Cross-Over Studies</subject><subject>Erythrocyte Count</subject><subject>Hematocrit</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Leukocyte Count</subject><subject>Leukocytes - cytology</subject><subject>Leukocytes - drug effects</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nicotine - blood</subject><subject>Platelet Count</subject><subject>Platelets</subject><subject>Red blood cells</subject><subject>Reduced exposure</subject><subject>Smoking</subject><subject>Smoking - adverse effects</subject><subject>Smoking - blood</subject><subject>Smoking Cessation - methods</subject><subject>White blood cells</subject><issn>0273-2300</issn><issn>1096-0295</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctuFDEQRS0EIkPgC5CQd2zoofzo14IFiiAgRWJBsrbcdpnx0N1ubDeQP8hnx8MEhLKAlVX2rVNWHUKeM9gyYM3r_fY65mW35VBuQG4B6gdkw6BvKuB9_ZBsgLei4gLghDxJaQ8AvOvax-SEg-hl28OG3HzehZhpxjhRdA5NTjQ4GtGuBi3Fn0tIa0SaAzX-i46YM9I0ha9Iw0x_7HwphzEESw2OY3pFl1FnHLFg9GwPnL-fqZ-ptuuY78NiekoeOT0mfHZ3npKr9-8uzz5UF5_OP569vaiM6CFX6AQbxCBqLZxtuGWdMxKG2gkrmeScQctlI11tm44ZrQcJzrbIrcCa64aJU_LyyF1i-LZiymry6fA5PWNYk2obztuu7bv_J4VgsueyLUlxTJoYUoro1BL9pOO1YqAOrtRe_XKlDq4USFVcla4Xd_x1mND-6fktpwTeHANY9vHdY1TJeJyLFx-LKGWD_-eAWz2TqHI</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>Roethig, Hans J.</creator><creator>Koval, Tamara</creator><creator>Muhammad-Kah, Raheema</creator><creator>Jin, Yan</creator><creator>Mendes, Paul</creator><creator>Unverdorben, Martin</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7ST</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>SOI</scope></search><sort><creationdate>20100701</creationdate><title>Short term effects of reduced exposure to cigarette smoke on white blood cells, platelets and red blood cells in adult cigarette smokers</title><author>Roethig, Hans J. ; 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| subjects | Adult Blood Platelets - cytology Blood Platelets - drug effects Cigarettes smoke exposure Cross-Over Studies Erythrocyte Count Hematocrit Humans Inflammation Leukocyte Count Leukocytes - cytology Leukocytes - drug effects Male Middle Aged Nicotine - blood Platelet Count Platelets Red blood cells Reduced exposure Smoking Smoking - adverse effects Smoking - blood Smoking Cessation - methods White blood cells |
| title | Short term effects of reduced exposure to cigarette smoke on white blood cells, platelets and red blood cells in adult cigarette smokers |
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