In vivo delivery of small interfering RNA to tumors and their vasculature by novel dendritic nanocarriers

New targets for RNA interference (RNAi)-based cancer therapy are constantly emerging from the increasing knowledge on key molecular pathways that are paramount for carcinogenesis. Nevertheless, in vivo delivery of small interfering RNA (siRNA) remains a crucial challenge for therapeutic success. siR...

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Veröffentlicht in:	The FASEB journal 2010-09, Vol.24 (9), p.3122-3134
Hauptverfasser:	Ofek, Paula, Fischer, Wiebke, Calderón, Marcelo, Haag, Rainer, Satchi-Fainaro, Ronit
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Animals Cell Line Cell Line, Tumor Cell Survival - genetics Cell Survival - physiology dendrimers Dendrimers - administration & dosage Dendrimers - chemistry Gene Silencing - physiology glioblastoma Humans luciferase Mice Microscopy, Atomic Force Nanotechnology Neoplasms - therapy noninvasive intravital imaging polymer therapeutics RNA, Small Interfering - administration & dosage RNA, Small Interfering - genetics RNA, Small Interfering - physiology Scattering, Radiation
Online-Zugang:	Volltext
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