Therapy of tuberculosis in mice by DNA vaccination

Mycobacterium tuberculosis continues to kill about 3 million people every year 1 , more than any other single infectious agent. This is attributed primarily to an inadequate immune response towards infecting bacteria, which suffer growth inhibition rather than death and subsequently multiply catastr...

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Veröffentlicht in:	Nature (London) 1999-07, Vol.400 (6741), p.269-271
Hauptverfasser:	Lowrie, Douglas B., Tascon, Ricardo E., Bonato, Vania L. D., Lima, Valeria M. F., Faccioli, Lucia H., Stavropoulos, Evangelos, Colston, M. Joseph, Hewinson, Robert G., Moelling, Karin, Silva, Celio L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Bacterial - genetics Antigens, Bacterial - immunology Antitubercular Agents - therapeutic use Bacterial diseases Bacterial Proteins Bacteriology Biological and medical sciences Chaperonin 60 Chaperonins - genetics Combined Modality Therapy Deoxyribonucleic acid DNA Experimental bacterial diseases and models Female Fundamental and applied biological sciences. Psychology Humanities and Social Sciences Immune response Immune system Immunotherapy Infectious diseases Interferon-gamma - metabolism Interleukin-12 - secretion Interleukin-4 - metabolism Isoniazid - therapeutic use letter Medical sciences Mice Mice, Inbred BALB C Microbiology multidisciplinary Mycobacterium leprae - genetics Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - immunology Plasmids Pyrazinamide - therapeutic use Rodents Science Science (multidisciplinary) T-Lymphocytes - immunology T-Lymphocytes - metabolism Tuberculosis Tuberculosis - immunology Tuberculosis - therapy Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, DNA - immunology Vaccines, DNA - therapeutic use
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