l-deprenyl test in migraine: neuroendocrinological aspects
We evaluated the effect of l-deprenyl, a drug that increases the availability of endogenous dopamine, on the plasma levels of prolactin and growth hormone in 10 female patients with migraine and in 10 control subjects matched for age and menstrual phase. The patients showed a significant decrease in...
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| Veröffentlicht in: | Cephalalgia 1993-12, Vol.13 (6), p.406-409 |
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| container_title | Cephalalgia |
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| creator | Calabresi, P Silvestrini, M Stratta, F Cupini, L M Argiro, G Atzei, G P Bernardi, G |
| description | We evaluated the effect of l-deprenyl, a drug that increases the availability of endogenous dopamine, on the plasma levels of prolactin and growth hormone in 10 female patients with migraine and in 10 control subjects matched for age and menstrual phase. The patients showed a significant decrease in prolactin levels at 30, 60 and 120 min after the oral administration of 5 mg of l-deprenyl when compared with the values obtained in controls (p < 0.001). The effects of l-deprenyl on growth hormone plasma levels were not significantly different between patients and controls. These data suggest that l-deprenyl inhibits prolactin release in migraine patients, but not in control subjects. This differential sensitivity could be explained by dopamine receptor supersensitivity in migraine patients. |
| doi_str_mv | 10.1046/j.1468-2982.1993.1306406.x |
| format | Article |
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The patients showed a significant decrease in prolactin levels at 30, 60 and 120 min after the oral administration of 5 mg of l-deprenyl when compared with the values obtained in controls (p < 0.001). The effects of l-deprenyl on growth hormone plasma levels were not significantly different between patients and controls. These data suggest that l-deprenyl inhibits prolactin release in migraine patients, but not in control subjects. This differential sensitivity could be explained by dopamine receptor supersensitivity in migraine patients.</description><identifier>ISSN: 0333-1024</identifier><identifier>DOI: 10.1046/j.1468-2982.1993.1306406.x</identifier><identifier>PMID: 8313454</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Female ; Growth Hormone - blood ; Humans ; Migraine Disorders - blood ; Migraine Disorders - physiopathology ; Neurosecretory Systems - physiopathology ; Prolactin - blood ; Reference Values ; Selegiline - pharmacology</subject><ispartof>Cephalalgia, 1993-12, Vol.13 (6), p.406-409</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8313454$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Calabresi, P</creatorcontrib><creatorcontrib>Silvestrini, M</creatorcontrib><creatorcontrib>Stratta, F</creatorcontrib><creatorcontrib>Cupini, L M</creatorcontrib><creatorcontrib>Argiro, G</creatorcontrib><creatorcontrib>Atzei, G P</creatorcontrib><creatorcontrib>Bernardi, G</creatorcontrib><title>l-deprenyl test in migraine: neuroendocrinological aspects</title><title>Cephalalgia</title><addtitle>Cephalalgia</addtitle><description>We evaluated the effect of l-deprenyl, a drug that increases the availability of endogenous dopamine, on the plasma levels of prolactin and growth hormone in 10 female patients with migraine and in 10 control subjects matched for age and menstrual phase. The patients showed a significant decrease in prolactin levels at 30, 60 and 120 min after the oral administration of 5 mg of l-deprenyl when compared with the values obtained in controls (p < 0.001). The effects of l-deprenyl on growth hormone plasma levels were not significantly different between patients and controls. These data suggest that l-deprenyl inhibits prolactin release in migraine patients, but not in control subjects. This differential sensitivity could be explained by dopamine receptor supersensitivity in migraine patients.</description><subject>Adult</subject><subject>Female</subject><subject>Growth Hormone - blood</subject><subject>Humans</subject><subject>Migraine Disorders - blood</subject><subject>Migraine Disorders - physiopathology</subject><subject>Neurosecretory Systems - physiopathology</subject><subject>Prolactin - blood</subject><subject>Reference Values</subject><subject>Selegiline - pharmacology</subject><issn>0333-1024</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotj01LxDAYhHNQ1nX1JwjFg7fWpG-SJnuTxS9Y8KLnkjZvlyxpWpMW3H_vip3LwPAwzBByz2jBKJePx4JxqfJSq7JgWkPBgEpOZfFzQdYUAHJGS35FrlM6UkqFpHJFVgoYcMHXZOtzi2PEcPLZhGnKXMh6d4jGBdxmAec4YLBDG10Y_HBwrfGZSSO2U7ohl53xCW8X35Cvl-fP3Vu-_3h93z3t85GBmnIlsGG60whKtNY0VWPO-Z94hZ2xXSO47gwaDhW1nDGFJSLjXBtmAQxsyMN_7xiH7_m8se5datF7E3CYU13JsqwUFWfwbgHnpkdbj9H1Jp7q5Sz8AsauV14</recordid><startdate>199312</startdate><enddate>199312</enddate><creator>Calabresi, P</creator><creator>Silvestrini, M</creator><creator>Stratta, F</creator><creator>Cupini, L M</creator><creator>Argiro, G</creator><creator>Atzei, G P</creator><creator>Bernardi, G</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199312</creationdate><title>l-deprenyl test in migraine: neuroendocrinological aspects</title><author>Calabresi, P ; Silvestrini, M ; Stratta, F ; Cupini, L M ; Argiro, G ; Atzei, G P ; Bernardi, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p138t-85eb19f9e385cdab7ba138888847efadfb549faea4370d4118e2ee1449a1d33a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Female</topic><topic>Growth Hormone - blood</topic><topic>Humans</topic><topic>Migraine Disorders - blood</topic><topic>Migraine Disorders - physiopathology</topic><topic>Neurosecretory Systems - physiopathology</topic><topic>Prolactin - blood</topic><topic>Reference Values</topic><topic>Selegiline - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Calabresi, P</creatorcontrib><creatorcontrib>Silvestrini, M</creatorcontrib><creatorcontrib>Stratta, F</creatorcontrib><creatorcontrib>Cupini, L M</creatorcontrib><creatorcontrib>Argiro, G</creatorcontrib><creatorcontrib>Atzei, G P</creatorcontrib><creatorcontrib>Bernardi, G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cephalalgia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Calabresi, P</au><au>Silvestrini, M</au><au>Stratta, F</au><au>Cupini, L M</au><au>Argiro, G</au><au>Atzei, G P</au><au>Bernardi, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>l-deprenyl test in migraine: neuroendocrinological aspects</atitle><jtitle>Cephalalgia</jtitle><addtitle>Cephalalgia</addtitle><date>1993-12</date><risdate>1993</risdate><volume>13</volume><issue>6</issue><spage>406</spage><epage>409</epage><pages>406-409</pages><issn>0333-1024</issn><abstract>We evaluated the effect of l-deprenyl, a drug that increases the availability of endogenous dopamine, on the plasma levels of prolactin and growth hormone in 10 female patients with migraine and in 10 control subjects matched for age and menstrual phase. 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| ispartof | Cephalalgia, 1993-12, Vol.13 (6), p.406-409 |
| issn | 0333-1024 |
| language | eng |
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| source | Access via SAGE; MEDLINE; Access via Wiley Online Library |
| subjects | Adult Female Growth Hormone - blood Humans Migraine Disorders - blood Migraine Disorders - physiopathology Neurosecretory Systems - physiopathology Prolactin - blood Reference Values Selegiline - pharmacology |
| title | l-deprenyl test in migraine: neuroendocrinological aspects |
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