Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells

Casitas B-cell lymphoma (Cbl)-family E3 ubiquitin ligases are negative regulators of tyrosine kinase signaling. Recent work has revealed a critical role of Cbl in the maintenance of hematopoietic stem cell (HSC) homeostasis, and mutations in CBL have been identified in myeloid malignancies. Here we...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-09, Vol.107 (37), p.16274-16279
Hauptverfasser:	Naramura, Mayumi, Nandwani, Neha, Gu, Hua, Band, Vimla, Band, Hamid
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - deficiency Adaptor Proteins, Signal Transducing - metabolism Aging Animals Biological Sciences Blood Bone marrow Bone marrow cells Cbl protein Cbl-b protein Cell Proliferation Cytokines double prime B-cell lymphoma Genetic mutation Hematology Hematopoietic stem cells Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - metabolism Homeostasis Kinases Lymphoma Malignancy Mice Mice, Inbred C57BL Mice, Knockout Mutation Myeloproliferative diseases Myeloproliferative disorders Myeloproliferative Disorders - genetics Myeloproliferative Disorders - metabolism Myeloproliferative Disorders - pathology Proteins Proto-Oncogene Proteins c-cbl - deficiency Proto-Oncogene Proteins c-cbl - metabolism Rodents Stem cells Thrombopoietin - metabolism Time Factors Ubiquitin-protein ligase
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