Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a multisystem, autoimmune disease that predominantly affects women. Previous findings that duplicated Toll-like receptor 7 (Tlr7) promotes lupus-like disease in male BXSB mice prompted us to evaluate TLR7 in human SLE. By using a candidate gene approach, we iden...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-09, Vol.107 (36), p.15838-15843
Hauptverfasser:	Shen, Nan, Fu, Qiong, Deng, Yun, Qian, Xiaoxia, Zhao, Jian, Kaufman, Kenneth M., Wu, Yee Ling, Yu, C. Yung, Tang, Yuanjia, Chen, Ji-Yih, Yang, Wanling, Wong, Maida, Kawasaki, Aya, Tsuchiya, Naoyuki, Sumida, Takayuki, Kawaguchi, Yasushi, Howe, Hwee Siew, Mok, Mo Yin, Bang, So-Young, Liu, Fei-Lan, Chang, Deh-Ming, Takasaki, Yoshinari, Hashimoto, Hiroshi, Harley, John B., Guthridge, Joel M., Grossman, Jennifer M., Cantor, Rita M., Song, Yeong Wook, Bae, Sang-Cheol, Chen, Shunle, Hahn, Bevra H., Lau, Yu Lung, Tsao, Betty P., Smith, Kenneth G. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Alleles Asian Continental Ancestry Group Asians Autoimmune diseases Biological Sciences Data processing Gender differences Gene polymorphism Genes Genetic Diseases, X-Linked - genetics Genetic loci Genetic Predisposition to Disease Genotypes Heterozygotes Human genetics Humans Interferon Lupus Lupus Erythematosus, Systemic - genetics Male Males Messenger RNA Polymorphism Polymorphism, Single Nucleotide Rheumatology RNA, Messenger - genetics Sex chromosomes Sex differences Sex Factors Single-nucleotide polymorphism Systemic lupus erythematosus TLR7 protein Toll-Like Receptor 7 - genetics Toll-like receptors X chromosome
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