A Comparative Analysis of FISH, RT-PCR, PCR, and Immunohistochemistry for the Diagnosis of Mantle Cell Lymphomas

Mantle cell lymphoma (MCL) diagnosis first relies on morphology and phenotype that may overlap with other B-cell lymphomas. Therefore, the demonstration of t(11;14)(q13;q32), the cytogenetic hallmark of MCL, is considered of diagnostic value. By studying a series of 35 MCL with characteristic morpho...

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Veröffentlicht in:	Modern pathology 2002-05, Vol.15 (5), p.517-525
Hauptverfasser:	Belaud-Rotureau, Marc-Antoine, Parrens, Marie, Dubus, Pierre, Garroste, Jean-Christophe, de Mascarel, Antoine, Merlio, Jean-Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD20 - analysis Blotting, Southern CCND1 CD5 Antigens - analysis Chromosomes, Human, Pair 11 - genetics Chromosomes, Human, Pair 14 - genetics Cyclin D1 Cyclin D1 - analysis Cyclin D1 - genetics DNA, Neoplasm - genetics FISH Humans Immunohistochemistry In Situ Hybridization, Fluorescence Laboratory Medicine Lymphoma, Mantle-Cell - genetics Lymphoma, Mantle-Cell - metabolism Lymphoma, Mantle-Cell - pathology Mantle cell lymphoma Medicine Medicine & Public Health original-article Pathology PCR Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism RT-PCR t(11 14)(q13 q32) Translocation, Genetic
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