DNA Topoisomerase IIa in Multiple Myeloma: A Marker of Cell Proliferation and Not Drug Resistance

DNA topoisomerase IIa (topo IIa) is the target for a number of antineoplastic agents. Down-regulation of this enzyme is one form of drug resistance. Topo IIa is also involved in DNA replication and transcription and serves as an indicator of proliferation rate in many human malignancies. This study...

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Veröffentlicht in:	Modern pathology 2001-09, Vol.14 (9), p.886-891
Hauptverfasser:	Wilson, Carla S, Medeiros, LJeffrey, Lai, Raymond, Butch, Anthony W, McCourty, Althea, Kelly, Kathy, Brynes, Russell K
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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