Immunosuppressive regulatory T cells are associated with aggressive breast cancer phenotypes: a potential therapeutic target

FoxP3 is a marker for immunosuppressive CD25+CD4+ regulatory T cells. These regulatory T cells are thought to play a role in inducing immune tolerance to antigens and may be selectively recruited by carcinomas. We investigated whether breast carcinomas had significant numbers of FoxP3-positive regul...

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Veröffentlicht in:	Modern pathology 2008-12, Vol.21 (12), p.1527-1532
Hauptverfasser:	Bohling, Sandra D, Allison, Kimberly H
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Breast cancer Breast Neoplasms - immunology Breast Neoplasms - pathology Disease Estrogens Female Forkhead Transcription Factors - immunology Humans Immune Tolerance Immunohistochemistry Laboratory Medicine Lymphocytes Medical prognosis Medicine Medicine & Public Health original-article Pathology Phenotype Prognosis T-Lymphocytes, Regulatory - immunology Tumors
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