Methylation in the p53 Promoter Is a Supplementary Route to Breast Carcinogenesis: Correlation between CpG Methylation in the p53 Promoter and the Mutation of the p53 Gene in the Progression from Ductal Carcinoma In Situ to Invasive Ductal Carcinoma

Aberrant methylation in the CpG sites located in the promoter region of several tumor suppressor genes has been reported in various types of cancers. However, the methylation status of the p53 promoter has not been clearly determined and no information is available on its role in breast cancer. The...

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Veröffentlicht in:	Laboratory investigation 2001-04, Vol.81 (4), p.573-579
Hauptverfasser:	Kang, Joo Hyun, Kim, Sun Jung, Noh, Dong-Young, Park, In Ae, Choe, Kuk Jin, Yoo, Ook Joon, Kang, Han-Sung
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Breast Neoplasms - genetics Breast Neoplasms - pathology Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - pathology Carcinoma, Intraductal, Noninfiltrating - genetics Carcinoma, Intraductal, Noninfiltrating - pathology CpG Islands Disease Progression DNA Methylation DNA, Neoplasm - chemistry Female Gene Expression Regulation, Neoplastic Genes, p53 Gynecology. Andrology. Obstetrics Humans Laboratory Medicine Mammary gland diseases Medical sciences Medicine Medicine & Public Health Mutation Pathology Promoter Regions, Genetic Tumors
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