Natural evolution of TEM-1 β-lactamase: experimental reconstruction and clinical relevance

TEM-1 β-lactamase is one of the most well-known antibiotic resistance determinants around. It confers resistance to penicillins and early cephalosporins and has shown an astonishing functional plasticity in response to the introduction of novel drugs derived from these antibiotics. Since its discove...

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Veröffentlicht in:	FEMS microbiology reviews 2010-11, Vol.34 (6), p.1015-1036
Hauptverfasser:	Salverda, Merijn L.M, de Visser, J. Arjan G.M, Barlow, Miriam
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid resistance Amino acids Anti-Bacterial Agents - pharmacology Antibiotic resistance Antibiotics Bacteria - chemistry Bacteria - drug effects Bacteria - enzymology Bacteria - genetics Bacterial Infections - microbiology beta-Lactamases - chemistry beta-Lactamases - genetics beta-Lactamases - metabolism Biological and medical sciences Cephalosporins Clinical isolates directed evolution Drug resistance Drug Resistance, Bacterial Evolution evolution of antibiotic resistance Evolution, Molecular Functional plasticity Fundamental and applied biological sciences. Psychology Humans Laboratories Microbiology Molecular Conformation Mutation Phenotypes predicting antibiotic resistance structure-activity relationships structure–function relationship TEM β-lactamase
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