HLA class I allele associations with HCV genetic variants in patients with chronic HCV genotypes 1a or 1b infection

Background & Aims The adaptive immune response against hepatitis C virus (HCV) is significantly shaped by the host’s composition of HLA-alleles with the consequence that the HLA phenotype is a critical determinant of viral evolution during adaptive immune pressure. In the present study, we aimed...

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Veröffentlicht in:	Journal of hepatology 2010-12, Vol.53 (6), p.1022-1028
Hauptverfasser:	Lange, Christian Markus, Roomp, Kirsten, Dragan, Anette, Nattermann, Jacob, Michalk, Monika, Spengler, Ulrich, Weich, Viola, Lengauer, Thomas, Zeuzem, Stefan, Berg, Thomas, Sarrazin, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Alleles Base Sequence Biological and medical sciences CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - virology Cohort Studies DNA Primers - genetics Epitopes Female Gastroenterology and Hepatology Gastroenterology. Liver. Pancreas. Abdomen Genes, MHC Class I Genetic Association Studies Genetic variants Genetic Variation Genotype Hepacivirus - classification Hepacivirus - genetics Hepacivirus - immunology Hepatitis C Hepatitis C, Chronic - genetics Hepatitis C, Chronic - immunology Hepatitis C, Chronic - virology HLA-restricted epitopes Host-Pathogen Interactions - genetics Host-Pathogen Interactions - immunology Human viral diseases Humans Immune pressure Infectious diseases Male Medical sciences Middle Aged Phylogeny Prospective Studies RNA, Viral - blood RNA, Viral - genetics Viral diseases Viral Envelope Proteins - genetics Viral hepatitis Viral Nonstructural Proteins - genetics Young Adult
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