Molecular mechanisms of necroptosis: an ordered cellular explosion

Key Points Although for a long time necrosis was considered to be a purely accidental cell death subroutine, multiple lines of evidence now show that necrotic cell death can be regulated, both in its occurrence and in its course. The term 'necroptosis' was introduced by Yuan's researc...

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Veröffentlicht in:	Nature reviews. Molecular cell biology 2010-10, Vol.11 (10), p.700-714
Hauptverfasser:	Vandenabeele, Peter, Galluzzi, Lorenzo, Vanden Berghe, Tom, Kroemer, Guido
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/82/2344 631/80/86 A20 protein Adenosine diphosphate Animals Apoptosis Apoptosis - physiology Bacterial infections Biochemistry Biomedical and Life Sciences Cancer Research Caspase-8 Cell Biology Cell death Cell Death - physiology Cell Membrane - pathology Cell Membrane - physiology Cytotoxic factors Cytotoxicity Death receptors Developmental Biology Disintegration DNA damage Drug development FADD protein Fas-associated protein Humans In vivo methods and tests Internalization Kinases Life Sciences Ligands Lysosomes Lysosomes - pathology Lysosomes - physiology Macrophages - microbiology Macrophages - pathology Mitochondria Mitochondria - pathology Mitochondria - physiology Molecular modelling Morphogenesis - physiology Morphology Mortality Necrosis Nematodes NF-κB protein Pathogens Phylogeny Plasma membranes Poly(ADP-ribose) Poly(ADP-ribose) polymerase Protein kinase Protein Kinases - metabolism Proteins Reactive oxygen species Receptors, Death Domain - physiology Receptors, Tumor Necrosis Factor, Type I - physiology Retinoic acid review-article Ribose Shigella flexneri - pathogenicity Signal transduction Stem Cells Tumor necrosis factor-TNF Tumors Viral infections Yeasts
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