Role of drug absorption in the pharmacokinetics of therapeutic interventions for stroke
Absorption is a critical component of the pharmacokinetics for solid dosage forms administered orally. Many barriers must be overcome in order for a drug molecule to reach its effect site. To effectively address each of these barriers, drug‐specific properties, formulation issues, and (patho)physiol...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 2010-10, Vol.1207 (1), p.134-142 |
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| creator | Conrado, Daniela J. Gonzalez, Daniel Derendorf, Hartmut |
| description | Absorption is a critical component of the pharmacokinetics for solid dosage forms administered orally. Many barriers must be overcome in order for a drug molecule to reach its effect site. To effectively address each of these barriers, drug‐specific properties, formulation issues, and (patho)physiological changes in the gastrointestinal tract must be considered. First‐pass metabolism in the gut and/or liver can dictate the extent to which a drug reaches the systemic circulation. Drug‐metabolizing enzymes in the gut and liver are very susceptible to inhibition by other drugs, increasing the risk of drug interactions. In this paper, we will discuss absorption‐related issues for solid dosage forms used in the management of stroke patients. |
| doi_str_mv | 10.1111/j.1749-6632.2010.05729.x |
| format | Article |
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Many barriers must be overcome in order for a drug molecule to reach its effect site. To effectively address each of these barriers, drug‐specific properties, formulation issues, and (patho)physiological changes in the gastrointestinal tract must be considered. First‐pass metabolism in the gut and/or liver can dictate the extent to which a drug reaches the systemic circulation. Drug‐metabolizing enzymes in the gut and liver are very susceptible to inhibition by other drugs, increasing the risk of drug interactions. 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Many barriers must be overcome in order for a drug molecule to reach its effect site. To effectively address each of these barriers, drug‐specific properties, formulation issues, and (patho)physiological changes in the gastrointestinal tract must be considered. First‐pass metabolism in the gut and/or liver can dictate the extent to which a drug reaches the systemic circulation. Drug‐metabolizing enzymes in the gut and liver are very susceptible to inhibition by other drugs, increasing the risk of drug interactions. In this paper, we will discuss absorption‐related issues for solid dosage forms used in the management of stroke patients.</description><subject>absorption</subject><subject>Administration, Oral</subject><subject>Anticoagulants - administration & dosage</subject><subject>Anticoagulants - pharmacokinetics</subject><subject>clopidogrel</subject><subject>dipyridamole</subject><subject>Dipyridamole - administration & dosage</subject><subject>Dipyridamole - pharmacokinetics</subject><subject>Drug dosages</subject><subject>Humans</subject><subject>Intestinal Absorption</subject><subject>Medical research</subject><subject>pharmacodynamics</subject><subject>pharmacokinetics</subject><subject>Platelet Aggregation Inhibitors - administration & dosage</subject><subject>Platelet Aggregation Inhibitors - pharmacokinetics</subject><subject>Stroke - drug therapy</subject><subject>Stroke - metabolism</subject><subject>Stroke - prevention & control</subject><subject>Ticlopidine - administration & dosage</subject><subject>Ticlopidine - analogs & derivatives</subject><subject>Ticlopidine - pharmacokinetics</subject><subject>Warfarin - administration & dosage</subject><subject>Warfarin - pharmacokinetics</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAURi0EokPhFZAlFqwy-N_OBqkaQalUiiigEWwsx7mhmcnEwU7o9O1xmDILNuCNfa_P_SzrIIQpWdK8Xm2WVIuyUIqzJSO5S6Rm5XL_AC2OFw_RghCtC1MyfoKepLQhhDIj9GN0wkgppeBqgdbXoQMcGlzH6Tt2VQpxGNvQ47bH4w3g4cbFnfNh2_Ywtj7NaO5HN8CU64yNEH9CP88k3ISI0xjDFp6iR43rEjy730_Rl7dvPq_eFZcfzi9WZ5eFF0qXRaUdN77kdQ1e0Zo2TnnKfdUIzlxTEyEbxqmhWjswzlPfUA_SUeIrUxHJ-Cl6ecgdYvgxQRrtrk0eus71EKZktWJMUyn5v0lZcsa1UZl88Re5CVPs8zdsThKiVMLoTJkD5WNIKUJjh9juXLyzlNjZkt3YWYadZdjZkv1tye7z6PP7B6ZqB_Vx8I-WDLw-ALdtB3f_HWyvvp59mo85oDgEtGmE_THAxa1Vmmtp11fn9htbX6_ef6RW8l-h6bDV</recordid><startdate>201010</startdate><enddate>201010</enddate><creator>Conrado, Daniela J.</creator><creator>Gonzalez, Daniel</creator><creator>Derendorf, Hartmut</creator><general>Blackwell Publishing Inc</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope><scope>7X8</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope></search><sort><creationdate>201010</creationdate><title>Role of drug absorption in the pharmacokinetics of therapeutic interventions for stroke</title><author>Conrado, Daniela J. ; Gonzalez, Daniel ; Derendorf, Hartmut</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4679-b7a38c93ddec61d1fa6c13cbf432afd045f2318177ae8ac1cf1ce5a10cb8b0523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>absorption</topic><topic>Administration, Oral</topic><topic>Anticoagulants - administration & dosage</topic><topic>Anticoagulants - pharmacokinetics</topic><topic>clopidogrel</topic><topic>dipyridamole</topic><topic>Dipyridamole - administration & dosage</topic><topic>Dipyridamole - pharmacokinetics</topic><topic>Drug dosages</topic><topic>Humans</topic><topic>Intestinal Absorption</topic><topic>Medical research</topic><topic>pharmacodynamics</topic><topic>pharmacokinetics</topic><topic>Platelet Aggregation Inhibitors - administration & dosage</topic><topic>Platelet Aggregation Inhibitors - pharmacokinetics</topic><topic>Stroke - drug therapy</topic><topic>Stroke - metabolism</topic><topic>Stroke - prevention & control</topic><topic>Ticlopidine - administration & dosage</topic><topic>Ticlopidine - analogs & derivatives</topic><topic>Ticlopidine - pharmacokinetics</topic><topic>Warfarin - administration & dosage</topic><topic>Warfarin - pharmacokinetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Conrado, Daniela J.</creatorcontrib><creatorcontrib>Gonzalez, Daniel</creatorcontrib><creatorcontrib>Derendorf, Hartmut</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Conrado, Daniela J.</au><au>Gonzalez, Daniel</au><au>Derendorf, Hartmut</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of drug absorption in the pharmacokinetics of therapeutic interventions for stroke</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>2010-10</date><risdate>2010</risdate><volume>1207</volume><issue>1</issue><spage>134</spage><epage>142</epage><pages>134-142</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><coden>ANYAA9</coden><abstract>Absorption is a critical component of the pharmacokinetics for solid dosage forms administered orally. 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| subjects | absorption Administration, Oral Anticoagulants - administration & dosage Anticoagulants - pharmacokinetics clopidogrel dipyridamole Dipyridamole - administration & dosage Dipyridamole - pharmacokinetics Drug dosages Humans Intestinal Absorption Medical research pharmacodynamics pharmacokinetics Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - pharmacokinetics Stroke - drug therapy Stroke - metabolism Stroke - prevention & control Ticlopidine - administration & dosage Ticlopidine - analogs & derivatives Ticlopidine - pharmacokinetics Warfarin - administration & dosage Warfarin - pharmacokinetics |
| title | Role of drug absorption in the pharmacokinetics of therapeutic interventions for stroke |
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