Association Between Heme Oxygenase-1 Gene Promoter Polymorphisms and Type 2 Diabetes Mellitus: A HuGE Review and Meta-Analysis
Several studies have recently focused on the association between heme oxygenase-1 (HMOX1) gene promoter polymorphisms and susceptibility to type 2 diabetes mellitus; however, results have been conflicting. This systematic Human Genome Epidemiology review and meta-analysis was undertaken to integrate...
Gespeichert in:
| Veröffentlicht in: | American journal of epidemiology 2010-09, Vol.172 (6), p.631-636 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 636 |
|---|---|
| container_issue | 6 |
| container_start_page | 631 |
| container_title | American journal of epidemiology |
| container_volume | 172 |
| creator | Bao, Wei Song, Fangfang Li, Xiangyang Rong, Shuang Yang, Wei Wang, Di Xu, Jiqu Fu, Juan Zhao, Yanting Liu, Liegang |
| description | Several studies have recently focused on the association between heme oxygenase-1 (HMOX1) gene promoter polymorphisms and susceptibility to type 2 diabetes mellitus; however, results have been conflicting. This systematic Human Genome Epidemiology review and meta-analysis was undertaken to integrate previous findings and summarize the effect size of the association of HMOX1 gene promoter polymorphisms with susceptibility to type 2 diabetes. The authors retrieved all studies matched to search terms from the PubMed/MEDLINE, EMBASE, and ISI Web of Science databases that had been published through December 31, 2009. The articles were then checked independently by 2 investigators according to the eligibility and exclusion criteria. For all alleles and genotypes, odds ratios were pooled using either fixed-effects or random-effects models. An increased odds ratio for type 2 diabetes was observed in persons with the (GT)n L (long) allele as compared with those with the (GT)n S (short) allele (odds ratio = 1.12, 95% confidence interval: 1.02, 1.24; P = 0.02). Furthermore, the diabetes odds ratio for persons with the LL genotype, versus those with the SS genotype, was significantly increased (odds ratio = 1.25, 95% confidence interval: 1.04, 1.50; P = 0.02). Persons carrying longer (GT)n repeats in the HMOX1 gene promoter may have a higher risk of type 2 diabetes. |
| doi_str_mv | 10.1093/aje/kwq162 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_762271406</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>755179229</sourcerecordid><originalsourceid>FETCH-LOGICAL-c547t-f6964ee6f63fae78bf4c4f462aaaca1d29dcee6bc094d031ca1e9529310770253</originalsourceid><addsrcrecordid>eNqN0V1rFDEUBuAgil1Xb_wBEgQRhLH5mmTTu7WtO2JLS6lQ9iZks2c02_nYJjPdzo2_3bS7VvBGrwLnPLwc8iL0mpKPlGi-b1ewf725oZI9QSMqlMwky-VTNCKEsEwzyfbQixhXhFCqc_Ic7TEiJyyneoR-TmNsnbedbxv8CboNQIMLqAGf3Q3fobERMopn0AA-D23ddhDweVsNdRvWP3ysI7bNEl8Oa8AMH3m7gA4iPoWq8l0fD_AUF_3sGF_ArYfNgz2FzmbTxlZD9PElelbaKsKr3TtG3z4fXx4W2cnZ7Mvh9CRzuVBdVkotBYAsJS8tqMmiFE6UQjJrrbN0yfTSpfXCES2WhNM0A50zzSlRirCcj9H7be46tDc9xM7UPrp0pW2g7aNRkjFFBZH_lnlKzaVg_yFzqjRLV4zR27_kqu1D-oIHJDQnbJLQhy1yoY0xQGnWwdc2DIYSc9-zST2bbc8Jv9kl9osalo_0d7EJvNsBG52tymAb5-Mfx5nQgt4HZVvnYwd3j3sbro1UXOWmuJqbKzrXc37x1RT8F9M-v00</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>755493028</pqid></control><display><type>article</type><title>Association Between Heme Oxygenase-1 Gene Promoter Polymorphisms and Type 2 Diabetes Mellitus: A HuGE Review and Meta-Analysis</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Bao, Wei ; Song, Fangfang ; Li, Xiangyang ; Rong, Shuang ; Yang, Wei ; Wang, Di ; Xu, Jiqu ; Fu, Juan ; Zhao, Yanting ; Liu, Liegang</creator><creatorcontrib>Bao, Wei ; Song, Fangfang ; Li, Xiangyang ; Rong, Shuang ; Yang, Wei ; Wang, Di ; Xu, Jiqu ; Fu, Juan ; Zhao, Yanting ; Liu, Liegang</creatorcontrib><description>Several studies have recently focused on the association between heme oxygenase-1 (HMOX1) gene promoter polymorphisms and susceptibility to type 2 diabetes mellitus; however, results have been conflicting. This systematic Human Genome Epidemiology review and meta-analysis was undertaken to integrate previous findings and summarize the effect size of the association of HMOX1 gene promoter polymorphisms with susceptibility to type 2 diabetes. The authors retrieved all studies matched to search terms from the PubMed/MEDLINE, EMBASE, and ISI Web of Science databases that had been published through December 31, 2009. The articles were then checked independently by 2 investigators according to the eligibility and exclusion criteria. For all alleles and genotypes, odds ratios were pooled using either fixed-effects or random-effects models. An increased odds ratio for type 2 diabetes was observed in persons with the (GT)n L (long) allele as compared with those with the (GT)n S (short) allele (odds ratio = 1.12, 95% confidence interval: 1.02, 1.24; P = 0.02). Furthermore, the diabetes odds ratio for persons with the LL genotype, versus those with the SS genotype, was significantly increased (odds ratio = 1.25, 95% confidence interval: 1.04, 1.50; P = 0.02). Persons carrying longer (GT)n repeats in the HMOX1 gene promoter may have a higher risk of type 2 diabetes.</description><identifier>ISSN: 0002-9262</identifier><identifier>EISSN: 1476-6256</identifier><identifier>DOI: 10.1093/aje/kwq162</identifier><identifier>PMID: 20682519</identifier><identifier>CODEN: AJEPAS</identifier><language>eng</language><publisher>Cary, NC: Oxford University Press</publisher><subject>Biological and medical sciences ; Diabetes ; diabetes mellitus ; Diabetes Mellitus, Type 2 - genetics ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Epidemiology ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; General aspects ; Genetic Predisposition to Disease ; genetics ; genome ; Genotype ; heme oxygenase-1 ; Heme Oxygenase-1 - genetics ; human ; Human Genome Project ; Humans ; Medical sciences ; Meta-analysis ; Microsatellite Repeats ; Miscellaneous ; Polymorphism ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk factors ; single nucleotide ; type 2</subject><ispartof>American journal of epidemiology, 2010-09, Vol.172 (6), p.631-636</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright Oxford Publishing Limited(England) Sep 15, 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c547t-f6964ee6f63fae78bf4c4f462aaaca1d29dcee6bc094d031ca1e9529310770253</citedby><cites>FETCH-LOGICAL-c547t-f6964ee6f63fae78bf4c4f462aaaca1d29dcee6bc094d031ca1e9529310770253</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23249412$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20682519$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bao, Wei</creatorcontrib><creatorcontrib>Song, Fangfang</creatorcontrib><creatorcontrib>Li, Xiangyang</creatorcontrib><creatorcontrib>Rong, Shuang</creatorcontrib><creatorcontrib>Yang, Wei</creatorcontrib><creatorcontrib>Wang, Di</creatorcontrib><creatorcontrib>Xu, Jiqu</creatorcontrib><creatorcontrib>Fu, Juan</creatorcontrib><creatorcontrib>Zhao, Yanting</creatorcontrib><creatorcontrib>Liu, Liegang</creatorcontrib><title>Association Between Heme Oxygenase-1 Gene Promoter Polymorphisms and Type 2 Diabetes Mellitus: A HuGE Review and Meta-Analysis</title><title>American journal of epidemiology</title><addtitle>Am J Epidemiol</addtitle><description>Several studies have recently focused on the association between heme oxygenase-1 (HMOX1) gene promoter polymorphisms and susceptibility to type 2 diabetes mellitus; however, results have been conflicting. This systematic Human Genome Epidemiology review and meta-analysis was undertaken to integrate previous findings and summarize the effect size of the association of HMOX1 gene promoter polymorphisms with susceptibility to type 2 diabetes. The authors retrieved all studies matched to search terms from the PubMed/MEDLINE, EMBASE, and ISI Web of Science databases that had been published through December 31, 2009. The articles were then checked independently by 2 investigators according to the eligibility and exclusion criteria. For all alleles and genotypes, odds ratios were pooled using either fixed-effects or random-effects models. An increased odds ratio for type 2 diabetes was observed in persons with the (GT)n L (long) allele as compared with those with the (GT)n S (short) allele (odds ratio = 1.12, 95% confidence interval: 1.02, 1.24; P = 0.02). Furthermore, the diabetes odds ratio for persons with the LL genotype, versus those with the SS genotype, was significantly increased (odds ratio = 1.25, 95% confidence interval: 1.04, 1.50; P = 0.02). Persons carrying longer (GT)n repeats in the HMOX1 gene promoter may have a higher risk of type 2 diabetes.</description><subject>Biological and medical sciences</subject><subject>Diabetes</subject><subject>diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Epidemiology</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>General aspects</subject><subject>Genetic Predisposition to Disease</subject><subject>genetics</subject><subject>genome</subject><subject>Genotype</subject><subject>heme oxygenase-1</subject><subject>Heme Oxygenase-1 - genetics</subject><subject>human</subject><subject>Human Genome Project</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Meta-analysis</subject><subject>Microsatellite Repeats</subject><subject>Miscellaneous</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Promoter Regions, Genetic</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Risk factors</subject><subject>single nucleotide</subject><subject>type 2</subject><issn>0002-9262</issn><issn>1476-6256</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0V1rFDEUBuAgil1Xb_wBEgQRhLH5mmTTu7WtO2JLS6lQ9iZks2c02_nYJjPdzo2_3bS7VvBGrwLnPLwc8iL0mpKPlGi-b1ewf725oZI9QSMqlMwky-VTNCKEsEwzyfbQixhXhFCqc_Ic7TEiJyyneoR-TmNsnbedbxv8CboNQIMLqAGf3Q3fobERMopn0AA-D23ddhDweVsNdRvWP3ysI7bNEl8Oa8AMH3m7gA4iPoWq8l0fD_AUF_3sGF_ArYfNgz2FzmbTxlZD9PElelbaKsKr3TtG3z4fXx4W2cnZ7Mvh9CRzuVBdVkotBYAsJS8tqMmiFE6UQjJrrbN0yfTSpfXCES2WhNM0A50zzSlRirCcj9H7be46tDc9xM7UPrp0pW2g7aNRkjFFBZH_lnlKzaVg_yFzqjRLV4zR27_kqu1D-oIHJDQnbJLQhy1yoY0xQGnWwdc2DIYSc9-zST2bbc8Jv9kl9osalo_0d7EJvNsBG52tymAb5-Mfx5nQgt4HZVvnYwd3j3sbro1UXOWmuJqbKzrXc37x1RT8F9M-v00</recordid><startdate>20100915</startdate><enddate>20100915</enddate><creator>Bao, Wei</creator><creator>Song, Fangfang</creator><creator>Li, Xiangyang</creator><creator>Rong, Shuang</creator><creator>Yang, Wei</creator><creator>Wang, Di</creator><creator>Xu, Jiqu</creator><creator>Fu, Juan</creator><creator>Zhao, Yanting</creator><creator>Liu, Liegang</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T2</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7U1</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20100915</creationdate><title>Association Between Heme Oxygenase-1 Gene Promoter Polymorphisms and Type 2 Diabetes Mellitus: A HuGE Review and Meta-Analysis</title><author>Bao, Wei ; Song, Fangfang ; Li, Xiangyang ; Rong, Shuang ; Yang, Wei ; Wang, Di ; Xu, Jiqu ; Fu, Juan ; Zhao, Yanting ; Liu, Liegang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c547t-f6964ee6f63fae78bf4c4f462aaaca1d29dcee6bc094d031ca1e9529310770253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Biological and medical sciences</topic><topic>Diabetes</topic><topic>diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Epidemiology</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>General aspects</topic><topic>Genetic Predisposition to Disease</topic><topic>genetics</topic><topic>genome</topic><topic>Genotype</topic><topic>heme oxygenase-1</topic><topic>Heme Oxygenase-1 - genetics</topic><topic>human</topic><topic>Human Genome Project</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Meta-analysis</topic><topic>Microsatellite Repeats</topic><topic>Miscellaneous</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Promoter Regions, Genetic</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Risk factors</topic><topic>single nucleotide</topic><topic>type 2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bao, Wei</creatorcontrib><creatorcontrib>Song, Fangfang</creatorcontrib><creatorcontrib>Li, Xiangyang</creatorcontrib><creatorcontrib>Rong, Shuang</creatorcontrib><creatorcontrib>Yang, Wei</creatorcontrib><creatorcontrib>Wang, Di</creatorcontrib><creatorcontrib>Xu, Jiqu</creatorcontrib><creatorcontrib>Fu, Juan</creatorcontrib><creatorcontrib>Zhao, Yanting</creatorcontrib><creatorcontrib>Liu, Liegang</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Risk Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>American journal of epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bao, Wei</au><au>Song, Fangfang</au><au>Li, Xiangyang</au><au>Rong, Shuang</au><au>Yang, Wei</au><au>Wang, Di</au><au>Xu, Jiqu</au><au>Fu, Juan</au><au>Zhao, Yanting</au><au>Liu, Liegang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association Between Heme Oxygenase-1 Gene Promoter Polymorphisms and Type 2 Diabetes Mellitus: A HuGE Review and Meta-Analysis</atitle><jtitle>American journal of epidemiology</jtitle><addtitle>Am J Epidemiol</addtitle><date>2010-09-15</date><risdate>2010</risdate><volume>172</volume><issue>6</issue><spage>631</spage><epage>636</epage><pages>631-636</pages><issn>0002-9262</issn><eissn>1476-6256</eissn><coden>AJEPAS</coden><abstract>Several studies have recently focused on the association between heme oxygenase-1 (HMOX1) gene promoter polymorphisms and susceptibility to type 2 diabetes mellitus; however, results have been conflicting. This systematic Human Genome Epidemiology review and meta-analysis was undertaken to integrate previous findings and summarize the effect size of the association of HMOX1 gene promoter polymorphisms with susceptibility to type 2 diabetes. The authors retrieved all studies matched to search terms from the PubMed/MEDLINE, EMBASE, and ISI Web of Science databases that had been published through December 31, 2009. The articles were then checked independently by 2 investigators according to the eligibility and exclusion criteria. For all alleles and genotypes, odds ratios were pooled using either fixed-effects or random-effects models. An increased odds ratio for type 2 diabetes was observed in persons with the (GT)n L (long) allele as compared with those with the (GT)n S (short) allele (odds ratio = 1.12, 95% confidence interval: 1.02, 1.24; P = 0.02). Furthermore, the diabetes odds ratio for persons with the LL genotype, versus those with the SS genotype, was significantly increased (odds ratio = 1.25, 95% confidence interval: 1.04, 1.50; P = 0.02). Persons carrying longer (GT)n repeats in the HMOX1 gene promoter may have a higher risk of type 2 diabetes.</abstract><cop>Cary, NC</cop><pub>Oxford University Press</pub><pmid>20682519</pmid><doi>10.1093/aje/kwq162</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9262 |
| ispartof | American journal of epidemiology, 2010-09, Vol.172 (6), p.631-636 |
| issn | 0002-9262 1476-6256 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_762271406 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Diabetes diabetes mellitus Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Epidemiology Etiopathogenesis. Screening. Investigations. Target tissue resistance General aspects Genetic Predisposition to Disease genetics genome Genotype heme oxygenase-1 Heme Oxygenase-1 - genetics human Human Genome Project Humans Medical sciences Meta-analysis Microsatellite Repeats Miscellaneous Polymorphism Polymorphism, Single Nucleotide Promoter Regions, Genetic Public health. Hygiene Public health. Hygiene-occupational medicine Risk factors single nucleotide type 2 |
| title | Association Between Heme Oxygenase-1 Gene Promoter Polymorphisms and Type 2 Diabetes Mellitus: A HuGE Review and Meta-Analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T15%3A43%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20Between%20Heme%20Oxygenase-1%20Gene%20Promoter%20Polymorphisms%20and%20Type%202%20Diabetes%20Mellitus:%20A%20HuGE%20Review%20and%20Meta-Analysis&rft.jtitle=American%20journal%20of%20epidemiology&rft.au=Bao,%20Wei&rft.date=2010-09-15&rft.volume=172&rft.issue=6&rft.spage=631&rft.epage=636&rft.pages=631-636&rft.issn=0002-9262&rft.eissn=1476-6256&rft.coden=AJEPAS&rft_id=info:doi/10.1093/aje/kwq162&rft_dat=%3Cproquest_cross%3E755179229%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=755493028&rft_id=info:pmid/20682519&rfr_iscdi=true |