Genomic instability after allogeneic hematopoietic cell transplantation is frequent in oral mucosa, particularly in patients with a history of chronic graft-versus-host disease, and rare in nasal mucosa
Genomic instability (GI) of cells may lead to their malignant transformation. Carcinoma after hematopoietic cell transplantation (HCT) frequently involves some (eg, oral) but not other (eg, nasal) epithelia. We examined GI in oral and nasal mucosal specimens from 105 subjects, including short-term (...
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| Veröffentlicht in: | Blood 2010-09, Vol.116 (10), p.1803-1806 |
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| creator | Khan, Faisal M. Sy, Sarah Louie, Polly Ugarte-Torres, Alejandra Berka, Noureddine Sinclair, Gary D. Stewart, Douglas A. Russell, James A. Storek, Jan |
| description | Genomic instability (GI) of cells may lead to their malignant transformation. Carcinoma after hematopoietic cell transplantation (HCT) frequently involves some (eg, oral) but not other (eg, nasal) epithelia. We examined GI in oral and nasal mucosal specimens from 105 subjects, including short-term (7-98 days, n = 32) and long-term (4-22 yrs, n = 25) allogeneic HCT survivors. Controls included autologous HCT survivors (n = 11), patients treated with chemotherapy without HCT (n = 9) and healthy controls (n = 27). GI was detected in 60% oral versus only 4% nasal specimens in long-term allogeneic HCT survivors (P < .001). None of the controls showed GI. In oral specimens, GI was significantly associated with history of oral chronic graft-versus-host disease (cGVHD). We conclude that GI after HCT is frequent in some (oral) but rare in other (nasal) epithelia. This may explain why some epithelia (especially those involved with cGVHD) are prone to develop cancer. |
| doi_str_mv | 10.1182/blood-2009-10-249201 |
| format | Article |
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Carcinoma after hematopoietic cell transplantation (HCT) frequently involves some (eg, oral) but not other (eg, nasal) epithelia. We examined GI in oral and nasal mucosal specimens from 105 subjects, including short-term (7-98 days, n = 32) and long-term (4-22 yrs, n = 25) allogeneic HCT survivors. Controls included autologous HCT survivors (n = 11), patients treated with chemotherapy without HCT (n = 9) and healthy controls (n = 27). GI was detected in 60% oral versus only 4% nasal specimens in long-term allogeneic HCT survivors (P < .001). None of the controls showed GI. In oral specimens, GI was significantly associated with history of oral chronic graft-versus-host disease (cGVHD). We conclude that GI after HCT is frequent in some (oral) but rare in other (nasal) epithelia. This may explain why some epithelia (especially those involved with cGVHD) are prone to develop cancer.</description><identifier>ISSN: 0006-4971</identifier><identifier>ISSN: 1528-0020</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood-2009-10-249201</identifier><identifier>PMID: 20548092</identifier><language>eng</language><publisher>Washington, DC: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Biological and medical sciences ; Chronic Disease ; Female ; Genomic Instability ; Graft vs Host Disease - etiology ; Hematologic and hematopoietic diseases ; Hematopoietic Stem Cell Transplantation - adverse effects ; Hematopoietic Stem Cell Transplantation - methods ; Humans ; Leukemia - surgery ; Lymphoma - surgery ; Male ; Medical sciences ; Middle Aged ; Mouth Mucosa - metabolism ; Mouth Mucosa - pathology ; Nasal Mucosa - metabolism ; Nasal Mucosa - pathology ; Neoplasms, Second Primary - diagnosis ; Neoplasms, Second Primary - etiology ; Neoplasms, Second Primary - genetics ; Time Factors ; Transplantation, Homologous ; Young Adult</subject><ispartof>Blood, 2010-09, Vol.116 (10), p.1803-1806</ispartof><rights>2010 American Society of Hematology</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-2fa524f95822183c223197f594cdd528c35ddb4c6d890c1d7f3ad214563b32193</citedby><cites>FETCH-LOGICAL-c469t-2fa524f95822183c223197f594cdd528c35ddb4c6d890c1d7f3ad214563b32193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23202831$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20548092$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khan, Faisal M.</creatorcontrib><creatorcontrib>Sy, Sarah</creatorcontrib><creatorcontrib>Louie, Polly</creatorcontrib><creatorcontrib>Ugarte-Torres, Alejandra</creatorcontrib><creatorcontrib>Berka, Noureddine</creatorcontrib><creatorcontrib>Sinclair, Gary D.</creatorcontrib><creatorcontrib>Stewart, Douglas A.</creatorcontrib><creatorcontrib>Russell, James A.</creatorcontrib><creatorcontrib>Storek, Jan</creatorcontrib><title>Genomic instability after allogeneic hematopoietic cell transplantation is frequent in oral mucosa, particularly in patients with a history of chronic graft-versus-host disease, and rare in nasal mucosa</title><title>Blood</title><addtitle>Blood</addtitle><description>Genomic instability (GI) of cells may lead to their malignant transformation. Carcinoma after hematopoietic cell transplantation (HCT) frequently involves some (eg, oral) but not other (eg, nasal) epithelia. We examined GI in oral and nasal mucosal specimens from 105 subjects, including short-term (7-98 days, n = 32) and long-term (4-22 yrs, n = 25) allogeneic HCT survivors. Controls included autologous HCT survivors (n = 11), patients treated with chemotherapy without HCT (n = 9) and healthy controls (n = 27). GI was detected in 60% oral versus only 4% nasal specimens in long-term allogeneic HCT survivors (P < .001). None of the controls showed GI. In oral specimens, GI was significantly associated with history of oral chronic graft-versus-host disease (cGVHD). We conclude that GI after HCT is frequent in some (oral) but rare in other (nasal) epithelia. This may explain why some epithelia (especially those involved with cGVHD) are prone to develop cancer.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Chronic Disease</subject><subject>Female</subject><subject>Genomic Instability</subject><subject>Graft vs Host Disease - etiology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Hematopoietic Stem Cell Transplantation - methods</subject><subject>Humans</subject><subject>Leukemia - surgery</subject><subject>Lymphoma - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mouth Mucosa - metabolism</subject><subject>Mouth Mucosa - pathology</subject><subject>Nasal Mucosa - metabolism</subject><subject>Nasal Mucosa - pathology</subject><subject>Neoplasms, Second Primary - diagnosis</subject><subject>Neoplasms, Second Primary - etiology</subject><subject>Neoplasms, Second Primary - genetics</subject><subject>Time Factors</subject><subject>Transplantation, Homologous</subject><subject>Young Adult</subject><issn>0006-4971</issn><issn>1528-0020</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhiMEoqXwBgj5grg0YI_t3eSChCooSJW4wDmatZ2ukWMHj1O0r8hT4bBLucHJsuf7_xnP3zTPBX8tRAdvdiEl2wLnfSt4C6oHLh4050JD13IO_GFzzjnftKrfirPmCdE3zoWSoB83Z8C16ngP583PaxfT5A3zkQrufPDlwHAsLjMMId266Gpx7yYsaU7elXozLgRWMkaaA8aCxafIPLExu--Li6V6sZQxsGkxifCSzZirbgmYw2EtzlVSOWI_fNkzZHtPJeUDSyMz-5xi7XGb6xDtncu0ULtPVJj15JDcJcNoWcbsVqeIdN_nafNoxEDu2em8aL5-eP_l6mN78_n609W7m9aoTV9aGFGDGnvdAYhOGgAp-u2oe2WsrcszUlu7U2Zju54bYbejRAtC6Y3cSRC9vGheHX3nnOp_qQyTp3UnGF1aaNhuALYCtPw_qRWXQmtVSXUkTU5E2Y3DnP2E-TAIPqxxD7_jHta416dj3FX24tRg2U3O3ov-5FuBlycAyWAYa2jG019OAodOrkZvj5yri7vzLg9kakTGWZ-dKYNN_t-T_ALTX81i</recordid><startdate>20100909</startdate><enddate>20100909</enddate><creator>Khan, Faisal M.</creator><creator>Sy, Sarah</creator><creator>Louie, Polly</creator><creator>Ugarte-Torres, Alejandra</creator><creator>Berka, Noureddine</creator><creator>Sinclair, Gary D.</creator><creator>Stewart, Douglas A.</creator><creator>Russell, James A.</creator><creator>Storek, Jan</creator><general>Elsevier Inc</general><general>Americain Society of Hematology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20100909</creationdate><title>Genomic instability after allogeneic hematopoietic cell transplantation is frequent in oral mucosa, particularly in patients with a history of chronic graft-versus-host disease, and rare in nasal mucosa</title><author>Khan, Faisal M. ; Sy, Sarah ; Louie, Polly ; Ugarte-Torres, Alejandra ; Berka, Noureddine ; Sinclair, Gary D. ; Stewart, Douglas A. ; Russell, James A. ; Storek, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-2fa524f95822183c223197f594cdd528c35ddb4c6d890c1d7f3ad214563b32193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Chronic Disease</topic><topic>Female</topic><topic>Genomic Instability</topic><topic>Graft vs Host Disease - etiology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematopoietic Stem Cell Transplantation - adverse effects</topic><topic>Hematopoietic Stem Cell Transplantation - methods</topic><topic>Humans</topic><topic>Leukemia - surgery</topic><topic>Lymphoma - surgery</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mouth Mucosa - metabolism</topic><topic>Mouth Mucosa - pathology</topic><topic>Nasal Mucosa - metabolism</topic><topic>Nasal Mucosa - pathology</topic><topic>Neoplasms, Second Primary - diagnosis</topic><topic>Neoplasms, Second Primary - etiology</topic><topic>Neoplasms, Second Primary - genetics</topic><topic>Time Factors</topic><topic>Transplantation, Homologous</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khan, Faisal M.</creatorcontrib><creatorcontrib>Sy, Sarah</creatorcontrib><creatorcontrib>Louie, Polly</creatorcontrib><creatorcontrib>Ugarte-Torres, Alejandra</creatorcontrib><creatorcontrib>Berka, Noureddine</creatorcontrib><creatorcontrib>Sinclair, Gary D.</creatorcontrib><creatorcontrib>Stewart, Douglas A.</creatorcontrib><creatorcontrib>Russell, James A.</creatorcontrib><creatorcontrib>Storek, Jan</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khan, Faisal M.</au><au>Sy, Sarah</au><au>Louie, Polly</au><au>Ugarte-Torres, Alejandra</au><au>Berka, Noureddine</au><au>Sinclair, Gary D.</au><au>Stewart, Douglas A.</au><au>Russell, James A.</au><au>Storek, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genomic instability after allogeneic hematopoietic cell transplantation is frequent in oral mucosa, particularly in patients with a history of chronic graft-versus-host disease, and rare in nasal mucosa</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>2010-09-09</date><risdate>2010</risdate><volume>116</volume><issue>10</issue><spage>1803</spage><epage>1806</epage><pages>1803-1806</pages><issn>0006-4971</issn><issn>1528-0020</issn><eissn>1528-0020</eissn><abstract>Genomic instability (GI) of cells may lead to their malignant transformation. Carcinoma after hematopoietic cell transplantation (HCT) frequently involves some (eg, oral) but not other (eg, nasal) epithelia. We examined GI in oral and nasal mucosal specimens from 105 subjects, including short-term (7-98 days, n = 32) and long-term (4-22 yrs, n = 25) allogeneic HCT survivors. Controls included autologous HCT survivors (n = 11), patients treated with chemotherapy without HCT (n = 9) and healthy controls (n = 27). GI was detected in 60% oral versus only 4% nasal specimens in long-term allogeneic HCT survivors (P < .001). None of the controls showed GI. In oral specimens, GI was significantly associated with history of oral chronic graft-versus-host disease (cGVHD). We conclude that GI after HCT is frequent in some (oral) but rare in other (nasal) epithelia. This may explain why some epithelia (especially those involved with cGVHD) are prone to develop cancer.</abstract><cop>Washington, DC</cop><pub>Elsevier Inc</pub><pmid>20548092</pmid><doi>10.1182/blood-2009-10-249201</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Biological and medical sciences Chronic Disease Female Genomic Instability Graft vs Host Disease - etiology Hematologic and hematopoietic diseases Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - methods Humans Leukemia - surgery Lymphoma - surgery Male Medical sciences Middle Aged Mouth Mucosa - metabolism Mouth Mucosa - pathology Nasal Mucosa - metabolism Nasal Mucosa - pathology Neoplasms, Second Primary - diagnosis Neoplasms, Second Primary - etiology Neoplasms, Second Primary - genetics Time Factors Transplantation, Homologous Young Adult |
| title | Genomic instability after allogeneic hematopoietic cell transplantation is frequent in oral mucosa, particularly in patients with a history of chronic graft-versus-host disease, and rare in nasal mucosa |
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