Segrosome structure revealed by a complex of ParR with centromere DNA

A crystal structure of the plasmid partition protein ParR bound to centromeric DNA is described. ParR binds the centromeric DNA repeats as a dimer-of-dimers, which assemble in a super-helical array to form a large segrosome with a solenoid-shaped structure. The stable inheritance of genetic material...

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Veröffentlicht in:	Nature 2007-12, Vol.450 (7173), p.1268-1271
Hauptverfasser:	Schumacher, Maria A., Glover, Tiffany C., Brzoska, Anthony J., Jensen, Slade O., Dunham, Thomas D., Skurray, Ronald A., Firth, Neville
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding sites Biological and medical sciences Cellular biology Centromere - genetics Centromere - metabolism Chromosome Segregation Crystal structure Crystalline structure Crystallography, X-Ray Crystals Deoxyribonucleic acid DNA DNA, Bacterial - chemistry DNA, Bacterial - genetics DNA, Bacterial - metabolism Fundamental and applied biological sciences. Psychology Humanities and Social Sciences letter Models, Molecular Molecular biophysics Molecular Conformation multidisciplinary Plasmids - chemistry Plasmids - genetics Plasmids - metabolism Proteins Repressor Proteins - chemistry Repressor Proteins - genetics Repressor Proteins - metabolism Science Science (multidisciplinary) Staphylococcus aureus Structure in molecular biology
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