Enhancement of binding activity of soluble human CD40 to CD40 ligand through incorporation of an isoleucine zipper motif

Aim： To investigate the effect of incorporation of an isoleucine zipper （IZ） motif into CD40 on binding activity of CD40 for the CD40 ligand （CD40L）. Methods： Prokaryotic expression vectors for 2 soluble CD40 derivatives, shCD40His and shCD40IZ containing an IZ dowain, were constructed and expressed...

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Veröffentlicht in:	Acta pharmacologica Sinica 2006-03, Vol.27 (3), p.333-338
Hauptverfasser:	He, Xian-hui, Xu, Li-hui, Liu, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding, Competitive CD40 CD40 Antigens - chemistry CD40 Antigens - metabolism CD40 Ligand - metabolism Escherichia coli Humans Isoleucine - chemistry Jurkat Cells Leucine Zippers Recombinant Proteins - metabolism 原核生物 埃希氏菌 异亮氨酸 配位体
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