Myc-binding-site recognition in the human genome is determined by chromatin context

Large-scale chromatin immunoprecipitation (ChIP) studies have been effective in unravelling the distribution of DNA-binding transcription factors along eukaryotic genomes, but specificity determinants remain elusive. Gene-regulatory regions display distinct histone variants and modifications (or mar...

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Veröffentlicht in:	Nature cell biology 2006-07, Vol.8 (7), p.764-770
Hauptverfasser:	Amati, Bruno, Guccione, Ernesto, Martinato, Francesca, Finocchiaro, Giacomo, Luzi, Lucilla, Tizzoni, Laura, Dall' Olio, Valentina, Zardo, Giuseppe, Nervi, Clara, Bernard, Loris
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals Binding Sites - genetics Biomedical and Life Sciences Cancer Research Cell Biology Cell Line Cell Nucleus - genetics Chromatin Chromatin - genetics Cluster Analysis Deoxyribonucleic acid Developmental Biology DNA DNA - metabolism DNA binding proteins DNA methylation Gene Expression Profiling Genetic aspects Genetic Markers - genetics Genome, Human - genetics Genomes Histones - genetics Histones - metabolism Humans letter Life Sciences Methylation Oligonucleotide Array Sequence Analysis Oncology Physiology Promoter Regions, Genetic - genetics Protein Binding - genetics Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Rats Stem Cells Transcription factors Transcription Factors - genetics Transcription Factors - metabolism
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