Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

We developed a novel system to create DNA double-strand breaks (DSBs) at defined endogenous sites in the human genome, and used this system to detect protein recruitment and loss at and around these breaks by chromatin immunoprecipitation (ChIP). The detection of human ATM protein at site-specific D...

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Veröffentlicht in:	Nature cell biology 2007-06, Vol.9 (6), p.683-690
Hauptverfasser:	Kastan, Michael B, Berkovich, Elijahu, Monnat, Raymond J
Format:	Artikel
Sprache:	eng
Schlagworte:	Ataxia Telangiectasia Mutated Proteins Cell Cycle Proteins - genetics Cell Cycle Proteins - physiology Cell Line, Tumor Cellular proteins Chromatin Chromatin - genetics Chromatin - metabolism Deoxyribonucleic acid DNA DNA - genetics DNA Breaks, Double-Stranded DNA repair DNA Repair - genetics DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Genetic aspects Genomes Humans Infections Kinases Methods Microscopy Nuclear Proteins - genetics Nuclear Proteins - physiology Nucleosomes - genetics Nucleosomes - metabolism Phosphorylation Physiological aspects Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - physiology Proteins Structure Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - physiology Yeast
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