Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors

The mechanisms controlling the commitment of haematopoietic progenitors to the B-lymphoid lineage are poorly understood. The observations that mice deficient in E2A and EBF lack B-lineage cells have implicated these two transcription factors in the commitment process. Moreover, the expression of gen...

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Veröffentlicht in:	Nature (London) 1999-10, Vol.401 (6753), p.603-606
Hauptverfasser:	Rolink, Antonius G, Nutt, Stephen L, Melchers, Fritz, Busslinger, Meinrad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - physiology Biological and medical sciences Bone marrow Bone Marrow Cells - physiology Cell Line Cells Clone Cells Cloning DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Rearrangement, B-Lymphocyte, Heavy Chain Genes Hematopoietic Stem Cells - physiology Humanities and Social Sciences Immunobiology Immunology letter Leukopoiesis Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Mice Mice, Inbred BALB C Mice, Inbred C57BL multidisciplinary Nuclear Proteins - physiology PAX5 Transcription Factor Rodents Science Science (multidisciplinary) T-Lymphocytes - physiology Thymus Gland - cytology Transcription Factors
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