In vitro anti-trypanosomal activity of elatol isolated from red seaweed Laurencia dendroidea
Chagas' disease is a debilitating but comparatively neglected illness that affects about 15 million people. There is an urgent need to develop new, more effective, and less-toxic compounds. In this study, we assessed the in vitro anti-trypanosomal activity of the sesquiterpene elatol from the B...
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creator | VEIGA-SANTOS, P. PELIZZARO-ROCHA, K. J. SANTOS, A. O. UEDA-NAKAMURA, T. FILHO, B. P. DIAS SILVA, S. O. SUDATTI, D. B. BIANCO, E. M. PEREIRA, R. C. NAKAMURA, C. V. |
description | Chagas' disease is a debilitating but comparatively neglected illness that affects about 15 million people. There is an urgent need to develop new, more effective, and less-toxic compounds. In this study, we assessed the in vitro anti-trypanosomal activity of the sesquiterpene elatol from the Brazilian red seaweed Laurencia dendroidea. We used electron microscopy to evaluate the effect of elatol on the morphology and ultrastructure of the parasite. Elatol showed a dose-dependent effect against the epimastigote, trypomastigote, and amastigote forms, with IC50 values of 45·4, 1·38, and 1·01 μm, respectively. Observation of treated intracellular amastigotes by light microscopy demonstrated a total elimination of the infection at a dose of 3·0 μm. In addition, the compound did not affect the red blood cells, and the CC50 value for LLCMK2 cells was 27·0 μm. Transmission and scanning electron micrographs showed aberrant-shaped cells and breaks in the plasma membrane, prominent swollen mitochondria, and extensive formation of cytoplasmic vacuoles in all the forms. This is the first report of the anti-trypanosomal effect of the sesquiterpene elatol. |
doi_str_mv | 10.1017/S003118201000034X |
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J. ; SANTOS, A. O. ; UEDA-NAKAMURA, T. ; FILHO, B. P. DIAS ; SILVA, S. O. ; SUDATTI, D. B. ; BIANCO, E. M. ; PEREIRA, R. C. ; NAKAMURA, C. V.</creator><creatorcontrib>VEIGA-SANTOS, P. ; PELIZZARO-ROCHA, K. J. ; SANTOS, A. O. ; UEDA-NAKAMURA, T. ; FILHO, B. P. DIAS ; SILVA, S. O. ; SUDATTI, D. B. ; BIANCO, E. M. ; PEREIRA, R. C. ; NAKAMURA, C. V.</creatorcontrib><description>Chagas' disease is a debilitating but comparatively neglected illness that affects about 15 million people. There is an urgent need to develop new, more effective, and less-toxic compounds. In this study, we assessed the in vitro anti-trypanosomal activity of the sesquiterpene elatol from the Brazilian red seaweed Laurencia dendroidea. We used electron microscopy to evaluate the effect of elatol on the morphology and ultrastructure of the parasite. Elatol showed a dose-dependent effect against the epimastigote, trypomastigote, and amastigote forms, with IC50 values of 45·4, 1·38, and 1·01 μm, respectively. Observation of treated intracellular amastigotes by light microscopy demonstrated a total elimination of the infection at a dose of 3·0 μm. In addition, the compound did not affect the red blood cells, and the CC50 value for LLCMK2 cells was 27·0 μm. Transmission and scanning electron micrographs showed aberrant-shaped cells and breaks in the plasma membrane, prominent swollen mitochondria, and extensive formation of cytoplasmic vacuoles in all the forms. This is the first report of the anti-trypanosomal effect of the sesquiterpene elatol.</description><identifier>ISSN: 0031-1820</identifier><identifier>EISSN: 1469-8161</identifier><identifier>DOI: 10.1017/S003118201000034X</identifier><identifier>PMID: 20546638</identifier><identifier>CODEN: PARAAE</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Algae ; Animals ; anti-trypanosomal activity ; Biological and medical sciences ; Cell Line ; elatol ; Erythrocytes - drug effects ; Erythrocytes - physiology ; Fundamental and applied biological sciences. Psychology ; General aspects ; General aspects and techniques. Study of several systematic groups. Models ; Humans ; Inhibitory Concentration 50 ; Invertebrates ; Laurencia ; Laurencia - classification ; Laurencia - metabolism ; Laurencia dendroidea ; Light microscopy ; Microscopy, Electron ; mitochondrion ; Parasites ; Parasitic Sensitivity Tests ; Spiro Compounds - chemistry ; Spiro Compounds - metabolism ; Spiro Compounds - pharmacology ; Trypanocidal Agents - chemistry ; Trypanocidal Agents - metabolism ; Trypanocidal Agents - pharmacology ; Trypanosoma cruzi ; Trypanosoma cruzi - drug effects ; Trypanosoma cruzi - growth & development ; Trypanosoma cruzi - ultrastructure ; Vector-borne diseases</subject><ispartof>Parasitology, 2010-09, Vol.137 (11), p.1661-1670</ispartof><rights>Copyright © Cambridge University Press 2010</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-d827cb62c3a21be1231b77e5fbbde4f3026187f2986effe1efdba8e5e4ea8c13</citedby><cites>FETCH-LOGICAL-c471t-d827cb62c3a21be1231b77e5fbbde4f3026187f2986effe1efdba8e5e4ea8c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S003118201000034X/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,777,781,27905,27906,55609</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23361470$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20546638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VEIGA-SANTOS, P.</creatorcontrib><creatorcontrib>PELIZZARO-ROCHA, K. J.</creatorcontrib><creatorcontrib>SANTOS, A. O.</creatorcontrib><creatorcontrib>UEDA-NAKAMURA, T.</creatorcontrib><creatorcontrib>FILHO, B. P. DIAS</creatorcontrib><creatorcontrib>SILVA, S. O.</creatorcontrib><creatorcontrib>SUDATTI, D. B.</creatorcontrib><creatorcontrib>BIANCO, E. M.</creatorcontrib><creatorcontrib>PEREIRA, R. C.</creatorcontrib><creatorcontrib>NAKAMURA, C. V.</creatorcontrib><title>In vitro anti-trypanosomal activity of elatol isolated from red seaweed Laurencia dendroidea</title><title>Parasitology</title><addtitle>Parasitology</addtitle><description>Chagas' disease is a debilitating but comparatively neglected illness that affects about 15 million people. There is an urgent need to develop new, more effective, and less-toxic compounds. In this study, we assessed the in vitro anti-trypanosomal activity of the sesquiterpene elatol from the Brazilian red seaweed Laurencia dendroidea. We used electron microscopy to evaluate the effect of elatol on the morphology and ultrastructure of the parasite. Elatol showed a dose-dependent effect against the epimastigote, trypomastigote, and amastigote forms, with IC50 values of 45·4, 1·38, and 1·01 μm, respectively. Observation of treated intracellular amastigotes by light microscopy demonstrated a total elimination of the infection at a dose of 3·0 μm. In addition, the compound did not affect the red blood cells, and the CC50 value for LLCMK2 cells was 27·0 μm. Transmission and scanning electron micrographs showed aberrant-shaped cells and breaks in the plasma membrane, prominent swollen mitochondria, and extensive formation of cytoplasmic vacuoles in all the forms. This is the first report of the anti-trypanosomal effect of the sesquiterpene elatol.</description><subject>Algae</subject><subject>Animals</subject><subject>anti-trypanosomal activity</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>elatol</subject><subject>Erythrocytes - drug effects</subject><subject>Erythrocytes - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>General aspects and techniques. Study of several systematic groups. Models</subject><subject>Humans</subject><subject>Inhibitory Concentration 50</subject><subject>Invertebrates</subject><subject>Laurencia</subject><subject>Laurencia - classification</subject><subject>Laurencia - metabolism</subject><subject>Laurencia dendroidea</subject><subject>Light microscopy</subject><subject>Microscopy, Electron</subject><subject>mitochondrion</subject><subject>Parasites</subject><subject>Parasitic Sensitivity Tests</subject><subject>Spiro Compounds - chemistry</subject><subject>Spiro Compounds - metabolism</subject><subject>Spiro Compounds - pharmacology</subject><subject>Trypanocidal Agents - chemistry</subject><subject>Trypanocidal Agents - metabolism</subject><subject>Trypanocidal Agents - pharmacology</subject><subject>Trypanosoma cruzi</subject><subject>Trypanosoma cruzi - drug effects</subject><subject>Trypanosoma cruzi - growth & development</subject><subject>Trypanosoma cruzi - ultrastructure</subject><subject>Vector-borne diseases</subject><issn>0031-1820</issn><issn>1469-8161</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqFkdFrFDEQxoMo9jz9A3yRRSg-rWaSbLL3qKW2hUNRC_oghNndiaTubs5kV73_vjnu2oIi5mUGvt8M8-Vj7Cnwl8DBvPrEuQSoBQeen1Rf7rEFKL0qa9Bwny12crnTj9ijlK4yo6UWD9mR4JXSWtYL9vViLH76KYYCx8mXU9xucAwpDNgX2E4-a9siuIJ6nEJf-BRyQ13hYhiKmJtE-ItyXeMcaWw9Fh2NXQy-I3zMHjjsEz051CW7fHt6eXJert-fXZy8XpetMjCVXS1M22jRShTQEAgJjTFUuabpSDnJhYbaOLGqNTlHQK5rsKaKFGHdglyyF_u1mxh-zJQmO_jUUt_jSGFO1mghDBdg_k9WKnOrfMGSPf-DvApzHLOLDFUAleEqQ7CH2hhSiuTsJvoB49YCt7uE7F8J5Zlnh8VzM1B3O3ETSQaODwCmFnsXMf9quuOk1KAMz1y553ya6PetjvG71UaayuqzD_bd-UfxeQ1v7M67PByLQxN9943uLP373GveBbcC</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>VEIGA-SANTOS, P.</creator><creator>PELIZZARO-ROCHA, K. 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J. ; SANTOS, A. O. ; UEDA-NAKAMURA, T. ; FILHO, B. P. DIAS ; SILVA, S. O. ; SUDATTI, D. B. ; BIANCO, E. M. ; PEREIRA, R. C. ; NAKAMURA, C. V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-d827cb62c3a21be1231b77e5fbbde4f3026187f2986effe1efdba8e5e4ea8c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Algae</topic><topic>Animals</topic><topic>anti-trypanosomal activity</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>elatol</topic><topic>Erythrocytes - drug effects</topic><topic>Erythrocytes - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>General aspects and techniques. Study of several systematic groups. 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J.</au><au>SANTOS, A. O.</au><au>UEDA-NAKAMURA, T.</au><au>FILHO, B. P. DIAS</au><au>SILVA, S. O.</au><au>SUDATTI, D. B.</au><au>BIANCO, E. M.</au><au>PEREIRA, R. C.</au><au>NAKAMURA, C. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro anti-trypanosomal activity of elatol isolated from red seaweed Laurencia dendroidea</atitle><jtitle>Parasitology</jtitle><addtitle>Parasitology</addtitle><date>2010-09-01</date><risdate>2010</risdate><volume>137</volume><issue>11</issue><spage>1661</spage><epage>1670</epage><pages>1661-1670</pages><issn>0031-1820</issn><eissn>1469-8161</eissn><coden>PARAAE</coden><abstract>Chagas' disease is a debilitating but comparatively neglected illness that affects about 15 million people. There is an urgent need to develop new, more effective, and less-toxic compounds. In this study, we assessed the in vitro anti-trypanosomal activity of the sesquiterpene elatol from the Brazilian red seaweed Laurencia dendroidea. We used electron microscopy to evaluate the effect of elatol on the morphology and ultrastructure of the parasite. Elatol showed a dose-dependent effect against the epimastigote, trypomastigote, and amastigote forms, with IC50 values of 45·4, 1·38, and 1·01 μm, respectively. Observation of treated intracellular amastigotes by light microscopy demonstrated a total elimination of the infection at a dose of 3·0 μm. In addition, the compound did not affect the red blood cells, and the CC50 value for LLCMK2 cells was 27·0 μm. Transmission and scanning electron micrographs showed aberrant-shaped cells and breaks in the plasma membrane, prominent swollen mitochondria, and extensive formation of cytoplasmic vacuoles in all the forms. This is the first report of the anti-trypanosomal effect of the sesquiterpene elatol.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>20546638</pmid><doi>10.1017/S003118201000034X</doi><tpages>10</tpages></addata></record> |
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subjects | Algae Animals anti-trypanosomal activity Biological and medical sciences Cell Line elatol Erythrocytes - drug effects Erythrocytes - physiology Fundamental and applied biological sciences. Psychology General aspects General aspects and techniques. Study of several systematic groups. Models Humans Inhibitory Concentration 50 Invertebrates Laurencia Laurencia - classification Laurencia - metabolism Laurencia dendroidea Light microscopy Microscopy, Electron mitochondrion Parasites Parasitic Sensitivity Tests Spiro Compounds - chemistry Spiro Compounds - metabolism Spiro Compounds - pharmacology Trypanocidal Agents - chemistry Trypanocidal Agents - metabolism Trypanocidal Agents - pharmacology Trypanosoma cruzi Trypanosoma cruzi - drug effects Trypanosoma cruzi - growth & development Trypanosoma cruzi - ultrastructure Vector-borne diseases |
title | In vitro anti-trypanosomal activity of elatol isolated from red seaweed Laurencia dendroidea |
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