In vitro anti-trypanosomal activity of elatol isolated from red seaweed Laurencia dendroidea

Chagas' disease is a debilitating but comparatively neglected illness that affects about 15 million people. There is an urgent need to develop new, more effective, and less-toxic compounds. In this study, we assessed the in vitro anti-trypanosomal activity of the sesquiterpene elatol from the B...

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Veröffentlicht in:Parasitology 2010-09, Vol.137 (11), p.1661-1670
Hauptverfasser: VEIGA-SANTOS, P., PELIZZARO-ROCHA, K. J., SANTOS, A. O., UEDA-NAKAMURA, T., FILHO, B. P. DIAS, SILVA, S. O., SUDATTI, D. B., BIANCO, E. M., PEREIRA, R. C., NAKAMURA, C. V.
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container_end_page 1670
container_issue 11
container_start_page 1661
container_title Parasitology
container_volume 137
creator VEIGA-SANTOS, P.
PELIZZARO-ROCHA, K. J.
SANTOS, A. O.
UEDA-NAKAMURA, T.
FILHO, B. P. DIAS
SILVA, S. O.
SUDATTI, D. B.
BIANCO, E. M.
PEREIRA, R. C.
NAKAMURA, C. V.
description Chagas' disease is a debilitating but comparatively neglected illness that affects about 15 million people. There is an urgent need to develop new, more effective, and less-toxic compounds. In this study, we assessed the in vitro anti-trypanosomal activity of the sesquiterpene elatol from the Brazilian red seaweed Laurencia dendroidea. We used electron microscopy to evaluate the effect of elatol on the morphology and ultrastructure of the parasite. Elatol showed a dose-dependent effect against the epimastigote, trypomastigote, and amastigote forms, with IC50 values of 45·4, 1·38, and 1·01 μm, respectively. Observation of treated intracellular amastigotes by light microscopy demonstrated a total elimination of the infection at a dose of 3·0 μm. In addition, the compound did not affect the red blood cells, and the CC50 value for LLCMK2 cells was 27·0 μm. Transmission and scanning electron micrographs showed aberrant-shaped cells and breaks in the plasma membrane, prominent swollen mitochondria, and extensive formation of cytoplasmic vacuoles in all the forms. This is the first report of the anti-trypanosomal effect of the sesquiterpene elatol.
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Observation of treated intracellular amastigotes by light microscopy demonstrated a total elimination of the infection at a dose of 3·0 μm. In addition, the compound did not affect the red blood cells, and the CC50 value for LLCMK2 cells was 27·0 μm. Transmission and scanning electron micrographs showed aberrant-shaped cells and breaks in the plasma membrane, prominent swollen mitochondria, and extensive formation of cytoplasmic vacuoles in all the forms. 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J.</creatorcontrib><creatorcontrib>SANTOS, A. O.</creatorcontrib><creatorcontrib>UEDA-NAKAMURA, T.</creatorcontrib><creatorcontrib>FILHO, B. P. DIAS</creatorcontrib><creatorcontrib>SILVA, S. O.</creatorcontrib><creatorcontrib>SUDATTI, D. B.</creatorcontrib><creatorcontrib>BIANCO, E. M.</creatorcontrib><creatorcontrib>PEREIRA, R. C.</creatorcontrib><creatorcontrib>NAKAMURA, C. V.</creatorcontrib><title>In vitro anti-trypanosomal activity of elatol isolated from red seaweed Laurencia dendroidea</title><title>Parasitology</title><addtitle>Parasitology</addtitle><description>Chagas' disease is a debilitating but comparatively neglected illness that affects about 15 million people. There is an urgent need to develop new, more effective, and less-toxic compounds. In this study, we assessed the in vitro anti-trypanosomal activity of the sesquiterpene elatol from the Brazilian red seaweed Laurencia dendroidea. 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subjects Algae
Animals
anti-trypanosomal activity
Biological and medical sciences
Cell Line
elatol
Erythrocytes - drug effects
Erythrocytes - physiology
Fundamental and applied biological sciences. Psychology
General aspects
General aspects and techniques. Study of several systematic groups. Models
Humans
Inhibitory Concentration 50
Invertebrates
Laurencia
Laurencia - classification
Laurencia - metabolism
Laurencia dendroidea
Light microscopy
Microscopy, Electron
mitochondrion
Parasites
Parasitic Sensitivity Tests
Spiro Compounds - chemistry
Spiro Compounds - metabolism
Spiro Compounds - pharmacology
Trypanocidal Agents - chemistry
Trypanocidal Agents - metabolism
Trypanocidal Agents - pharmacology
Trypanosoma cruzi
Trypanosoma cruzi - drug effects
Trypanosoma cruzi - growth & development
Trypanosoma cruzi - ultrastructure
Vector-borne diseases
title In vitro anti-trypanosomal activity of elatol isolated from red seaweed Laurencia dendroidea
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