Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system

Multiple sclerosis is a neuroinflammatory disease associated with axonal degeneration 1 , 2 . The neuronally expressed, proton-gated acid-sensing ion channel-1 (ASIC1) 3 , 4 is permeable to Na + and Ca 2+ , and excessive accumulation of these ions is associated with axonal degeneration 5 . We tested...

Ausführliche Beschreibung