Nek1 silencing slows down DNA repair and blocks DNA damage-induced cell cycle arrest

Never in mitosis A (NIMA)-related kinases (Nek) are evolutionarily conserved proteins structurally related to the Aspergillus nidulans mitotic regulator NIMA. Nek1 is one of the 11 isoforms of the Neks identified in mammals. Different lines of evidence suggest the participation of Nek1 in response t...

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Veröffentlicht in:	Mutagenesis 2010-09, Vol.25 (5), p.447-454
Hauptverfasser:	Pelegrini, Alessandra Luíza, Moura, Dinara Jaqueline, Brenner, Bethânia Luise, Ledur, Pitia Flores, Maques, Gabriela Porto, Henriques, João Antônio Pegas, Saffi, Jenifer, Lenz, Guido
Format:	Artikel
Sprache:	eng
Schlagworte:	Aspergillus nidulans Biological and medical sciences Camptothecin - pharmacology Cell Cycle - drug effects Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell cycle, cell proliferation Cell Division - drug effects Cell Line Cell physiology Cell Survival - drug effects Checkpoint Kinase 1 Cross-Linking Reagents - metabolism DNA Damage DNA Repair - drug effects Fundamental and applied biological sciences. Psychology G2 Phase - drug effects Gene Knockdown Techniques Gene Silencing - drug effects Histones - metabolism Humans Molecular and cellular biology Molecular genetics Mutagenesis. Repair Mutagens - toxicity NIMA-Related Kinase 1 Phosphorylation - drug effects Protein Kinases - metabolism Protein-Serine-Threonine Kinases - deficiency Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism
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