The Nrf2 transcription factor protects from toxin-induced liver injury and fibrosis

The liver is frequently exposed to insults, including toxic chemicals and alcohol, viral infection or metabolic overload. Although it can fully regenerate after acute injury, chronic liver damage causes liver fibrosis and cirrhosis, which can result in complete liver failure. In this study, we demon...

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Veröffentlicht in:	Laboratory investigation 2008-10, Vol.88 (10), p.1068-1078
Hauptverfasser:	Xu, Weihua, Hellerbrand, Claus, Köhler, Ulrike A, Bugnon, Philippe, Kan, Yuet-Wai, Werner, Sabine, Beyer, Tobias A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biotechnology Carbon Tetrachloride Poisoning - pathology Carbon Tetrachloride Poisoning - physiopathology Cytokines - metabolism Female Fundamental and applied biological sciences. Psychology Inflammation - pathology Inflammation - physiopathology Investigative techniques, diagnostic techniques (general aspects) Laboratory Medicine Liver Cirrhosis - chemically induced Liver Cirrhosis - pathology Liver Cirrhosis - physiopathology Medical sciences Medicine Medicine & Public Health Metabolic Detoxication, Phase I - physiology Mice Mice, Knockout NF-E2-Related Factor 2 - physiology Pathology research-article
Online-Zugang:	Volltext
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