The immune responses of sheep after DNA immunization with, Toxoplasma gondii MAG1 antigen—with and without co-expression of ovine interleukin 6

The aim of this study is to compare the immune responses of sheep stimulated by the intramuscular injection of a liposome formulated—DNA plasmid encoding the Toxoplasma gondii MAG1 antigen only or co-expressed with ovine IL-6. Forty-five, 2-year-old sheep were divided into four groups. Group 1 recei...

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Veröffentlicht in:	Veterinary immunology and immunopathology 2010-08, Vol.136 (3), p.324-329
Hauptverfasser:	Hiszczyńska-Sawicka, Elżbieta, Akhtar, Masood, Kay, Graham William, Holec-Gąsior, Lucyna, Bickerstaffe, Roy, Kur, Józef, Stankiewicz, Mirosław
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Protozoan - blood antigens Antigens, Protozoan - genetics Antigens, Protozoan - immunology biomarkers blood serum DNA Female humoral immunity Immunization Immunization - methods Immunization - veterinary immunoglobulin G Injections, Intramuscular - veterinary Interferon-gamma - blood Interleukin-6 - genetics Interleukin-6 - immunology interleukin-8 intramuscular injection liposomes (artificial) MAG1 (antigens) Ovine interleukin-6 plasmid vectors plasmids Plasmids - pharmacology protective effect Protozoan Vaccines - immunology Protozoan Vaccines - standards Sheep sheep diseases Sheep Diseases - immunology Sheep Diseases - parasitology Sheep Diseases - prevention & control Tissue cysts matrix antigen (MAG1) Toxoplasma - genetics Toxoplasma - immunology Toxoplasma gondii toxoplasmosis Toxoplasmosis, Animal - immunology Toxoplasmosis, Animal - parasitology Toxoplasmosis, Animal - prevention & control vaccination vaccine development vaccines Vaccines, DNA - immunology Vaccines, DNA - standards
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