Promoter hypomethylation contributes to the expression of MUC3A in cancer cells

MUC3A is a membrane-bound glycoprotein that is aberrantly expressed in carcinomas and is a risk factor for a poor prognosis. However, the exact mechanism of MUC3A expression has yet to be clarified. Here, we provide the first evidence that MUC3A gene expression is controlled by the CpG methylation s...

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Veröffentlicht in:	Biochemical and biophysical research communications 2010-06, Vol.397 (2), p.333-339
Hauptverfasser:	Kitamoto, Sho, Yamada, Norishige, Yokoyama, Seiya, Houjou, Izumi, Higashi, Michiyo, Yonezawa, Suguru
Format:	Artikel
Sprache:	eng
Schlagworte:	5' Flanking Region - genetics Azacitidine - analogs & derivatives Azacitidine - pharmacology Carcinoma - genetics Cell Line, Tumor DNA Methylation Epigenetic marker Gene Expression - drug effects Gene Expression Regulation, Neoplastic Gene Silencing Humans Hydroxamic Acids - pharmacology Hypomethylation MUC3A Mucin Mucin-3 - genetics RNA, Messenger - biosynthesis
Online-Zugang:	Volltext
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