Sustained production of Reelin-expressing interneurons in the hippocampal dentate hilus after developmental exposure to anti-thyroid agents in rats

To detect molecular evidence reflecting a permanent disruption of neuronal development due to hypothyroidism, distribution of Reelin-producing cells that function in neuronal migration and positioning was analyzed in the hippocampal dentate hilus using rats. From gestation day 10, maternal rats were...

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Veröffentlicht in:	Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2010-07, Vol.29 (4), p.407-414
Hauptverfasser:	Saegusa, Yukie, Woo, Gye-Hyeong, Fujimoto, Hitoshi, Kemmochi, Sayaka, Shimamoto, Keisuke, Hirose, Masao, Mitsumori, Kunitoshi, Nishikawa, Akiyoshi, Shibutani, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antithyroid Agents - toxicity Apoptosis Biological and medical sciences Calbindins Cell Adhesion Molecules, Neuronal - metabolism Cell Movement - drug effects Cell Proliferation - drug effects Dentate gyrus Dentate Gyrus - drug effects Dentate Gyrus - metabolism Dentate Gyrus - pathology Developmental hypothyroidism Embryology: invertebrates and vertebrates. Teratology Endocrinopathies Extracellular Matrix Proteins - metabolism Female Fundamental and applied biological sciences. Psychology GABAergic interneuron gamma-Aminobutyric Acid - metabolism Glutamate Decarboxylase - metabolism Impaired brain development Interneurons - drug effects Interneurons - metabolism Interneurons - pathology Male Maternal Exposure Medical sciences Methimazole - toxicity Migration Nerve Tissue Proteins - metabolism Neurogenesis Non tumoral diseases. Target tissue resistance. Benign neoplasms Peptide Fragments Pregnancy Propylthiouracil - toxicity Rats Rats, Sprague-Dawley Reelin S100 Calcium Binding Protein G - metabolism Serine Endopeptidases - metabolism Teratology. Teratogens Thyroid. Thyroid axis (diseases) Toxicology
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