Role of oxidatively induced DNA lesions in human pathogenesis

Genome stability is essential for maintaining cellular and organismal homeostasis, but it is subject to many threats. One ubiquitous threat is from a class of compounds known as reactive oxygen species (ROS), which can indiscriminately react with many cellular biomolecules including proteins, lipids...

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Veröffentlicht in:	Mutation research 2010-04, Vol.704 (1), p.152-159
Hauptverfasser:	Sedelnikova, Olga A., Redon, Christophe E., Dickey, Jennifer S., Nakamura, Asako J., Georgakilas, Alexandros G., Bonner, William M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Biological and medical sciences Bystander Effect Cancer Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cellular Senescence DNA Damage DNA double-strand breaks Fundamental and applied biological sciences. Psychology Humans Molecular and cellular biology Molecular genetics Mutagenesis. Repair Neoplasms - genetics Neoplasms - metabolism Oxidative Stress - genetics Reactive oxygen species
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