Pooled analysis of studies on DNA adducts and dietary vitamins
There is some evidence that dietary components that are rich in antioxidant and vitamins are inversely associated with DNA adduct levels induced by environmental carcinogens such as polycyclic aromatic hydrocarbons, although the epidemiologic data are inconsistent. This study addresses the associati...
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| Veröffentlicht in: | Mutation research 2010-10, Vol.705 (2), p.77-82 |
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| creator | Ragin, Camille Minor, Aerie Agudo, Antonio Farmer, Peter Garte, Seymour Gonzales, Carlos Kalina, Ivan Matullo, Giuseppe Popov, Todor Palli, Domenico Peluso, Marco Ricceri, Fulvio Sram, Radim Vineis, Paolo Taioli, Emanuela |
| description | There is some evidence that dietary components that are rich in antioxidant and vitamins are inversely associated with DNA adduct levels induced by environmental carcinogens such as polycyclic aromatic hydrocarbons, although the epidemiologic data are inconsistent. This study addresses the association between vitamins, DNA adducts and smoking.
A combined analysis of individual data on the association between bulky DNA adducts and dietary vitamins was conducted. A Medline search was performed to identify studies on healthy subjects in which smoking and vitamins intake information were available, and bulky DNA adducts were measured in peripheral blood with 32P-postlabelling. Eight published studies met the eligibility criteria, and individual data from 7 data sets including 2758 subjects were obtained. GSTM1 and GSTT1 were also available on all the subjects.
Vitamin E was inversely significantly associated with DNA adducts after adjustment for possible confounding factors. Vitamins A and C were not independent predictors of DNA adducts. A stratified analysis showed that vitamin A had a significant inverse association with DNA adducts in ever smokers only.
This result is relevant to planning any future chemo-preventive interventions directed to high risk subgroups of the population, for cancer prevention. |
| doi_str_mv | 10.1016/j.mrrev.2010.04.004 |
| format | Article |
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A combined analysis of individual data on the association between bulky DNA adducts and dietary vitamins was conducted. A Medline search was performed to identify studies on healthy subjects in which smoking and vitamins intake information were available, and bulky DNA adducts were measured in peripheral blood with 32P-postlabelling. Eight published studies met the eligibility criteria, and individual data from 7 data sets including 2758 subjects were obtained. GSTM1 and GSTT1 were also available on all the subjects.
Vitamin E was inversely significantly associated with DNA adducts after adjustment for possible confounding factors. Vitamins A and C were not independent predictors of DNA adducts. A stratified analysis showed that vitamin A had a significant inverse association with DNA adducts in ever smokers only.
This result is relevant to planning any future chemo-preventive interventions directed to high risk subgroups of the population, for cancer prevention.</description><identifier>ISSN: 1383-5742</identifier><identifier>ISSN: 0027-5107</identifier><identifier>EISSN: 1388-2139</identifier><identifier>EISSN: 1873-135X</identifier><identifier>DOI: 10.1016/j.mrrev.2010.04.004</identifier><identifier>PMID: 20399891</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Age Factors ; Antioxidants ; Antioxidants - analysis ; Biological and medical sciences ; Biomarkers ; Carcinogenicity ; Carcinogens - toxicity ; Diet ; DNA Adducts ; Environmental Exposure ; Fundamental and applied biological sciences. Psychology ; Humans ; Molecular and cellular biology ; Molecular epidemiology ; Molecular genetics ; Mutagenesis. Repair ; Smoking ; Vitamins - blood</subject><ispartof>Mutation research, 2010-10, Vol.705 (2), p.77-82</ispartof><rights>2010 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier B.V. All rights reserved.</rights><rights>2010 Elsevier B.V. All rights reserved. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c520t-8a7ced838bbd99e9fd8a92f69abec2b42d62ef1212dd6002992bff101c986e783</citedby><cites>FETCH-LOGICAL-c520t-8a7ced838bbd99e9fd8a92f69abec2b42d62ef1212dd6002992bff101c986e783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mrrev.2010.04.004$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23261194$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20399891$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ragin, Camille</creatorcontrib><creatorcontrib>Minor, Aerie</creatorcontrib><creatorcontrib>Agudo, Antonio</creatorcontrib><creatorcontrib>Farmer, Peter</creatorcontrib><creatorcontrib>Garte, Seymour</creatorcontrib><creatorcontrib>Gonzales, Carlos</creatorcontrib><creatorcontrib>Kalina, Ivan</creatorcontrib><creatorcontrib>Matullo, Giuseppe</creatorcontrib><creatorcontrib>Popov, Todor</creatorcontrib><creatorcontrib>Palli, Domenico</creatorcontrib><creatorcontrib>Peluso, Marco</creatorcontrib><creatorcontrib>Ricceri, Fulvio</creatorcontrib><creatorcontrib>Sram, Radim</creatorcontrib><creatorcontrib>Vineis, Paolo</creatorcontrib><creatorcontrib>Taioli, Emanuela</creatorcontrib><title>Pooled analysis of studies on DNA adducts and dietary vitamins</title><title>Mutation research</title><addtitle>Mutat Res</addtitle><description>There is some evidence that dietary components that are rich in antioxidant and vitamins are inversely associated with DNA adduct levels induced by environmental carcinogens such as polycyclic aromatic hydrocarbons, although the epidemiologic data are inconsistent. This study addresses the association between vitamins, DNA adducts and smoking.
A combined analysis of individual data on the association between bulky DNA adducts and dietary vitamins was conducted. A Medline search was performed to identify studies on healthy subjects in which smoking and vitamins intake information were available, and bulky DNA adducts were measured in peripheral blood with 32P-postlabelling. Eight published studies met the eligibility criteria, and individual data from 7 data sets including 2758 subjects were obtained. GSTM1 and GSTT1 were also available on all the subjects.
Vitamin E was inversely significantly associated with DNA adducts after adjustment for possible confounding factors. Vitamins A and C were not independent predictors of DNA adducts. A stratified analysis showed that vitamin A had a significant inverse association with DNA adducts in ever smokers only.
This result is relevant to planning any future chemo-preventive interventions directed to high risk subgroups of the population, for cancer prevention.</description><subject>Age Factors</subject><subject>Antioxidants</subject><subject>Antioxidants - analysis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Carcinogenicity</subject><subject>Carcinogens - toxicity</subject><subject>Diet</subject><subject>DNA Adducts</subject><subject>Environmental Exposure</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Molecular and cellular biology</subject><subject>Molecular epidemiology</subject><subject>Molecular genetics</subject><subject>Mutagenesis. Repair</subject><subject>Smoking</subject><subject>Vitamins - blood</subject><issn>1383-5742</issn><issn>0027-5107</issn><issn>1388-2139</issn><issn>1873-135X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAQhi1UxFf7C5BQLhWnLPY4OPahSIiPUgm1PbRny7HH1KskpnayEv--XnZL4dLTjMbvvPP6IeSY0QWjTJwtF0NKuFoALRPaLChtdsgB41LWwLh699zz-rxtYJ8c5rykFChndI_sl6qUVOyAXHyPsUdXmdH0TznkKvoqT7MLWNqxuv56WRnnZjvlInFVmU8mPVWrMJkhjPk92fWmz_hhW4_Iz9ubH1d39f23z1-uLu9rew50qqVpLTrJZdc5pVB5J40CL5Tp0ELXgBOAngED50SJqRR03pdfWiUFtpIfkYuN7-PcDegsjlMyvX5MYShxdDRBv30Zwy_9EFcaVNNysTY43Rqk-HvGPOkhZIt9b0aMc9atABBCMihKvlHaFHNO6F-uMKrX4PVSP4PXa_CaNrqAL1snrwO-7PwlXQQftwKTrel9MqMN-Z-Og2BMrY0-bXRYcK4CJp1twLHgCwntpF0M_w3yB02Ko3c</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Ragin, Camille</creator><creator>Minor, Aerie</creator><creator>Agudo, Antonio</creator><creator>Farmer, Peter</creator><creator>Garte, Seymour</creator><creator>Gonzales, Carlos</creator><creator>Kalina, Ivan</creator><creator>Matullo, Giuseppe</creator><creator>Popov, Todor</creator><creator>Palli, Domenico</creator><creator>Peluso, Marco</creator><creator>Ricceri, Fulvio</creator><creator>Sram, Radim</creator><creator>Vineis, Paolo</creator><creator>Taioli, Emanuela</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20101001</creationdate><title>Pooled analysis of studies on DNA adducts and dietary vitamins</title><author>Ragin, Camille ; Minor, Aerie ; Agudo, Antonio ; Farmer, Peter ; Garte, Seymour ; Gonzales, Carlos ; Kalina, Ivan ; Matullo, Giuseppe ; Popov, Todor ; Palli, Domenico ; Peluso, Marco ; Ricceri, Fulvio ; Sram, Radim ; Vineis, Paolo ; Taioli, Emanuela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c520t-8a7ced838bbd99e9fd8a92f69abec2b42d62ef1212dd6002992bff101c986e783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Age Factors</topic><topic>Antioxidants</topic><topic>Antioxidants - analysis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Carcinogenicity</topic><topic>Carcinogens - toxicity</topic><topic>Diet</topic><topic>DNA Adducts</topic><topic>Environmental Exposure</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Molecular and cellular biology</topic><topic>Molecular epidemiology</topic><topic>Molecular genetics</topic><topic>Mutagenesis. Repair</topic><topic>Smoking</topic><topic>Vitamins - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ragin, Camille</creatorcontrib><creatorcontrib>Minor, Aerie</creatorcontrib><creatorcontrib>Agudo, Antonio</creatorcontrib><creatorcontrib>Farmer, Peter</creatorcontrib><creatorcontrib>Garte, Seymour</creatorcontrib><creatorcontrib>Gonzales, Carlos</creatorcontrib><creatorcontrib>Kalina, Ivan</creatorcontrib><creatorcontrib>Matullo, Giuseppe</creatorcontrib><creatorcontrib>Popov, Todor</creatorcontrib><creatorcontrib>Palli, Domenico</creatorcontrib><creatorcontrib>Peluso, Marco</creatorcontrib><creatorcontrib>Ricceri, Fulvio</creatorcontrib><creatorcontrib>Sram, Radim</creatorcontrib><creatorcontrib>Vineis, Paolo</creatorcontrib><creatorcontrib>Taioli, Emanuela</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Mutation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ragin, Camille</au><au>Minor, Aerie</au><au>Agudo, Antonio</au><au>Farmer, Peter</au><au>Garte, Seymour</au><au>Gonzales, Carlos</au><au>Kalina, Ivan</au><au>Matullo, Giuseppe</au><au>Popov, Todor</au><au>Palli, Domenico</au><au>Peluso, Marco</au><au>Ricceri, Fulvio</au><au>Sram, Radim</au><au>Vineis, Paolo</au><au>Taioli, Emanuela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pooled analysis of studies on DNA adducts and dietary vitamins</atitle><jtitle>Mutation research</jtitle><addtitle>Mutat Res</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>705</volume><issue>2</issue><spage>77</spage><epage>82</epage><pages>77-82</pages><issn>1383-5742</issn><issn>0027-5107</issn><eissn>1388-2139</eissn><eissn>1873-135X</eissn><abstract>There is some evidence that dietary components that are rich in antioxidant and vitamins are inversely associated with DNA adduct levels induced by environmental carcinogens such as polycyclic aromatic hydrocarbons, although the epidemiologic data are inconsistent. This study addresses the association between vitamins, DNA adducts and smoking.
A combined analysis of individual data on the association between bulky DNA adducts and dietary vitamins was conducted. A Medline search was performed to identify studies on healthy subjects in which smoking and vitamins intake information were available, and bulky DNA adducts were measured in peripheral blood with 32P-postlabelling. Eight published studies met the eligibility criteria, and individual data from 7 data sets including 2758 subjects were obtained. GSTM1 and GSTT1 were also available on all the subjects.
Vitamin E was inversely significantly associated with DNA adducts after adjustment for possible confounding factors. Vitamins A and C were not independent predictors of DNA adducts. A stratified analysis showed that vitamin A had a significant inverse association with DNA adducts in ever smokers only.
This result is relevant to planning any future chemo-preventive interventions directed to high risk subgroups of the population, for cancer prevention.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>20399891</pmid><doi>10.1016/j.mrrev.2010.04.004</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Mutation research, 2010-10, Vol.705 (2), p.77-82 |
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| language | eng |
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| subjects | Age Factors Antioxidants Antioxidants - analysis Biological and medical sciences Biomarkers Carcinogenicity Carcinogens - toxicity Diet DNA Adducts Environmental Exposure Fundamental and applied biological sciences. Psychology Humans Molecular and cellular biology Molecular epidemiology Molecular genetics Mutagenesis. Repair Smoking Vitamins - blood |
| title | Pooled analysis of studies on DNA adducts and dietary vitamins |
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