Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells

We have recently reported that N-myc downstream-regulated gene 1 (NDRG1)/Ca 2+-associated protein with a molecular mass of 43 kDa (Cap43) suppresses angiogenesis and tumor growth of pancreatic cancer through marked decreases in both the expression of CXC chemokines and phosphorylation of a NF-κB sig...

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Veröffentlicht in:	Biochemical and biophysical research communications 2010-05, Vol.396 (2), p.376-381
Hauptverfasser:	Murakami, Yuichi, Hosoi, Fumihito, Izumi, Hiroto, Maruyama, Yuichiro, Ureshino, Hiroki, Watari, Kosuke, Kohno, Kimitoshi, Kuwano, Michihiko, Ono, Mayumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Angiogenesis Cap43 Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line, Tumor Chemokines, CXC - biosynthesis CXC chemokines Humans Immediate-Early Proteins - metabolism Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism NDRG1 Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism NF-kappa B - metabolism Pancreatic Neoplasms - blood supply Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Phosphorylation Protein-Serine-Threonine Kinases - metabolism Sequence Deletion Serine - genetics Serine - metabolism SGK1 Threonine - genetics Threonine - metabolism
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