drug hypoxen: A new inhibitor of mitochondrial respiration and dehydrogenases

drug hypoxen: A new inhibitor of mitochondrial respiration and dehydrogenases

The effect of hypoxen on the oxygen consumption and activity of dehydrogenases in rat liver mitochondria has been studied. The addition of hypoxen to mitochondria caused a reduction of the rate of phosphorylating and uncoupling respiration. The minimal effective concentration of hypoxen was 15 μg/ml...

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Veröffentlicht in:Biology bulletin of the Russian Academy of Sciences 2010-08, Vol.37 (4), p.346-350
Hauptverfasser: Kosenko, E. A, Abramova, M. B, Venediktova, N. I, Popova, I. I, Kaminskii, Yu. G
Format: Artikel
Sprache:eng
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Biochemistry
Biomedical and Life Sciences
Cell Biology
dehydrogenase
Drugs
Ecology
Electron transport
Life Sciences
Mitochondria
Zoology
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container_issue 4
container_start_page 346
container_title Biology bulletin of the Russian Academy of Sciences
container_volume 37
creator Kosenko, E. A
Abramova, M. B
Venediktova, N. I
Popova, I. I
Kaminskii, Yu. G
description The effect of hypoxen on the oxygen consumption and activity of dehydrogenases in rat liver mitochondria has been studied. The addition of hypoxen to mitochondria caused a reduction of the rate of phosphorylating and uncoupling respiration. The minimal effective concentration of hypoxen was 15 μg/ml with succinate, 60 μg/ml with pyruvate or palmitoylcarnitine, and 120 μg/ml with glutamate as the substrates. The activities of malate, glutamate, and succinate dehydrogenases in mitochondria were significantly decreased by the effect of hypoxen.
doi_str_mv 10.1134/S1062359010040035
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subjects Biochemistry
Biomedical and Life Sciences
Cell Biology
dehydrogenase
Drugs
Ecology
Electron transport
Life Sciences
Mitochondria
Zoology
title drug hypoxen: A new inhibitor of mitochondrial respiration and dehydrogenases
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