Ovis aries CR4 is involved in Mannheimia haemolytica leukotoxin-induced cytotoxicity

Pneumonia caused by Mannheimia haemolytica is an important disease of domestic sheep (DS, Ovis aries) and cattle (BO). M. haemolytica is a normal commensal of the upper respiratory tract in ruminants, but during stress and viral infection it breaches the host innate mucosal defense and descents into...

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Veröffentlicht in:	Veterinary immunology and immunopathology 2010-06, Vol.135 (3), p.266-274
Hauptverfasser:	Lawrence, Paulraj K., Dassanayake, Rohana P.
Format:	Artikel
Sprache:	eng
Schlagworte:	alleles Amino Acid Sequence Animals bacterial pneumonia bacterial toxins Bacterial Toxins - immunology Bacterial Toxins - toxicity Base Sequence binding capacity Cattle Cell Line clones Cloning, Molecular CR4 cytolysis cytotoxicity Cytotoxins - immunology Cytotoxins - toxicity DNA Primers - genetics Domestic sheep Exotoxins - immunology Exotoxins - toxicity Humans immune response immune system in vitro studies Integrin alphaXbeta2 - chemistry Integrin alphaXbeta2 - genetics Integrin alphaXbeta2 - metabolism integrins leukocytes Leukotoxin leukotoxins Mannheimia haemolytica Mannheimia haemolytica - immunology Mannheimia haemolytica - pathogenicity Molecular Sequence Data Ovis aries Pasteurellaceae Infections - immunology Pasteurellaceae Infections - microbiology Pasteurellaceae Infections - veterinary Pasteurellosis, Pneumonic - immunology Pasteurellosis, Pneumonic - microbiology pathogenesis pathogenicity Protein Subunits receptors Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Ruminantia Sequence Homology, Amino Acid sheep Sheep - genetics Sheep - immunology sheep diseases Sheep Diseases - immunology Sheep Diseases - microbiology Transfection Virulence
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