Synthesis and biological activity of carboxylic acid replacement analogs of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline

The carboxylic acid group on the proline of 1 was replaced by a phosphoric acid, a hydroxamic acid, and a tetrazole to give compounds 2-4, respectively. Testing of 2-4 as angiotensin converting enzyme (ACE) inhibitors gave I50 values of 100, 1.6, and 22 microM, respectively, compared to 0.07 microM...

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Veröffentlicht in:	Journal of medicinal chemistry 1985-08, Vol.28 (8), p.1067-1071
Hauptverfasser:	Almquist, Ronald G, Chao, Wan Ru, Jennings-White, Clive
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-Converting Enzyme Inhibitors Animals Antihypertensive Agents - chemical synthesis Dipeptides - chemical synthesis Dipeptides - metabolism Dipeptides - pharmacology Hypertension, Renovascular - drug therapy Rats Structure-Activity Relationship
Online-Zugang:	Volltext
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