Prostaglandins E3 and D3 lower intraocular pressure
The effects of the prostaglandin (PG)-3 series products PGE3 and PGD3 on the intraocular pressure of rabbits were studied. PGE3 at 0.001 and 0.01 mg/eye and PGD3 at 0.01 and 0.05 mg/eye doses were applied topically (in 50-microliters volume) to the normal rabbit eye. Both PGE3 and PGD3 significantly...
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| Veröffentlicht in: | Investigative ophthalmology & visual science 1985-08, Vol.26 (8), p.1178-1182 |
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| creator | KULKARNI, P. S SRINIVASAN, B. D |
| description | The effects of the prostaglandin (PG)-3 series products PGE3 and PGD3 on the intraocular pressure of rabbits were studied. PGE3 at 0.001 and 0.01 mg/eye and PGD3 at 0.01 and 0.05 mg/eye doses were applied topically (in 50-microliters volume) to the normal rabbit eye. Both PGE3 and PGD3 significantly lowered intraocular pressure at all doses tested and the IOP lowering response lasted at least 240 min. Topical PGE3 at 0.01 mg/eye caused mild conjunctival hyperemia which lasted up to 180 min. PGD3, on the other hand, did not induce conjunctival hyperemia. In addition, following application of these PGs, there was no miosis or other sign of intraocular inflammation detectable by slit-lamp examination. |
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S ; SRINIVASAN, B. D</creator><creatorcontrib>KULKARNI, P. S ; SRINIVASAN, B. D</creatorcontrib><description>The effects of the prostaglandin (PG)-3 series products PGE3 and PGD3 on the intraocular pressure of rabbits were studied. PGE3 at 0.001 and 0.01 mg/eye and PGD3 at 0.01 and 0.05 mg/eye doses were applied topically (in 50-microliters volume) to the normal rabbit eye. Both PGE3 and PGD3 significantly lowered intraocular pressure at all doses tested and the IOP lowering response lasted at least 240 min. Topical PGE3 at 0.01 mg/eye caused mild conjunctival hyperemia which lasted up to 180 min. PGD3, on the other hand, did not induce conjunctival hyperemia. In addition, following application of these PGs, there was no miosis or other sign of intraocular inflammation detectable by slit-lamp examination.</description><identifier>ISSN: 0146-0404</identifier><identifier>EISSN: 1552-5783</identifier><identifier>PMID: 4019112</identifier><identifier>CODEN: IOVSDA</identifier><language>eng</language><publisher>Bethesda, MD: Association for Research in Vision and Ophtalmology</publisher><subject>Alprostadil - analogs & derivatives ; Animals ; Biological and medical sciences ; Eye ; Intraocular Pressure - drug effects ; Medical sciences ; Pharmacology. 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D</creatorcontrib><title>Prostaglandins E3 and D3 lower intraocular pressure</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>The effects of the prostaglandin (PG)-3 series products PGE3 and PGD3 on the intraocular pressure of rabbits were studied. PGE3 at 0.001 and 0.01 mg/eye and PGD3 at 0.01 and 0.05 mg/eye doses were applied topically (in 50-microliters volume) to the normal rabbit eye. Both PGE3 and PGD3 significantly lowered intraocular pressure at all doses tested and the IOP lowering response lasted at least 240 min. Topical PGE3 at 0.01 mg/eye caused mild conjunctival hyperemia which lasted up to 180 min. PGD3, on the other hand, did not induce conjunctival hyperemia. In addition, following application of these PGs, there was no miosis or other sign of intraocular inflammation detectable by slit-lamp examination.</description><subject>Alprostadil - analogs & derivatives</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Eye</subject><subject>Intraocular Pressure - drug effects</subject><subject>Medical sciences</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Prostaglandins D - pharmacology</topic><topic>Prostaglandins E - pharmacology</topic><topic>Rabbits</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KULKARNI, P. S</creatorcontrib><creatorcontrib>SRINIVASAN, B. D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KULKARNI, P. S</au><au>SRINIVASAN, B. D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prostaglandins E3 and D3 lower intraocular pressure</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>1985-08</date><risdate>1985</risdate><volume>26</volume><issue>8</issue><spage>1178</spage><epage>1182</epage><pages>1178-1182</pages><issn>0146-0404</issn><eissn>1552-5783</eissn><coden>IOVSDA</coden><abstract>The effects of the prostaglandin (PG)-3 series products PGE3 and PGD3 on the intraocular pressure of rabbits were studied. PGE3 at 0.001 and 0.01 mg/eye and PGD3 at 0.01 and 0.05 mg/eye doses were applied topically (in 50-microliters volume) to the normal rabbit eye. Both PGE3 and PGD3 significantly lowered intraocular pressure at all doses tested and the IOP lowering response lasted at least 240 min. Topical PGE3 at 0.01 mg/eye caused mild conjunctival hyperemia which lasted up to 180 min. PGD3, on the other hand, did not induce conjunctival hyperemia. In addition, following application of these PGs, there was no miosis or other sign of intraocular inflammation detectable by slit-lamp examination.</abstract><cop>Bethesda, MD</cop><pub>Association for Research in Vision and Ophtalmology</pub><pmid>4019112</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Investigative ophthalmology & visual science, 1985-08, Vol.26 (8), p.1178-1182 |
| issn | 0146-0404 1552-5783 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Alprostadil - analogs & derivatives Animals Biological and medical sciences Eye Intraocular Pressure - drug effects Medical sciences Pharmacology. Drug treatments Prostaglandins D - pharmacology Prostaglandins E - pharmacology Rabbits |
| title | Prostaglandins E3 and D3 lower intraocular pressure |
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