Effect of protein intake on renal function and structure in partially nephrectomized rats
Effects of protein intake on renal function and structure in partially nephrectomized rats. To examine the effect of high protein intake on renal function and structure in rats with 5/6 nephrectomy chronic renal failure, we pairfed rats with chronic renal failure and sham-operated control rats diets...
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| Veröffentlicht in: | Kidney international 1985-05, Vol.27 (5), p.739-750 |
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| creator | Kenner, Charles H. Evan, Andrew P. Blomgren, Phillip Aronoff, George R. Luft, Friedrich C. |
| description | Effects of protein intake on renal function and structure in partially nephrectomized rats. To examine the effect of high protein intake on renal function and structure in rats with 5/6 nephrectomy chronic renal failure, we pairfed rats with chronic renal failure and sham-operated control rats diets of 14 or 37% protein content for up to 6 months. High protein intake accelerated mortality in rats with chronic renal failure and resulted in a more rapid rate of decrease in renal function as established by plotting the reciprocal of plasma creatinine versus time. High protein intake also increased urine protein excretion in experimental and control rats. High protein intake was associated with increased tubular dilatation and interstitial inflammation, both of which were striking features in rats with chronic renal failure. Glomerular sclerosis was prominent in rats with chronic renal failure. These rats had smaller glomerular tuft dimensions than control rats irrespective of their protein intake. We conclude that high protein intake accelerates the course of chronic renal failure in rats. The pathologic process involves glomerular sclerosis; however, interstitial inflammation and renal tubular changes leading to cyst formation also appear to influence the process adversely.
Effet de l'apport protéique sur la fonction et la structure rénales de rats partiellement néphrectomisés. Afin d'examiner l'effet d'un apport protéique élevé sur la fonction et la structure rénales de rats en insuffisance rénale chronique par néphrectomie des 5/6e, nous avons nourri de façon appariée des rats ayant subi un simulacre d'intervention avec des régimes contenant 14 ou 37% de protéines pendant 6 mois. Le fort apport protéique a accéléré la mortalité des rats en insuffisance rénale chronique et a entrainé une plus rapide vitesse de décroissance de la fonction rénale, établie en représentant l'inverse de la créatininémie en fonction du temps. Le fort apport protéique a également augmenté l'excrétion urinaire de protéines chez les rats contrôles et expérimentaux. Le fort apport protéique était associé à une augmentation de la dilatation tubulaire, et de l'inflammation interstitielle, chacune étant une caractéristique marquante des rats en insuffisance rénale chronique. La sclérose glomérulaire était notable chez les rats en insuffisance rénale chronique. Ces rats avaient des touffes glomérulaires de plus petites dimensions que les rats contrôles quel que soit leur apport protéique |
| doi_str_mv | 10.1038/ki.1985.74 |
| format | Article |
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Effet de l'apport protéique sur la fonction et la structure rénales de rats partiellement néphrectomisés. Afin d'examiner l'effet d'un apport protéique élevé sur la fonction et la structure rénales de rats en insuffisance rénale chronique par néphrectomie des 5/6e, nous avons nourri de façon appariée des rats ayant subi un simulacre d'intervention avec des régimes contenant 14 ou 37% de protéines pendant 6 mois. Le fort apport protéique a accéléré la mortalité des rats en insuffisance rénale chronique et a entrainé une plus rapide vitesse de décroissance de la fonction rénale, établie en représentant l'inverse de la créatininémie en fonction du temps. Le fort apport protéique a également augmenté l'excrétion urinaire de protéines chez les rats contrôles et expérimentaux. Le fort apport protéique était associé à une augmentation de la dilatation tubulaire, et de l'inflammation interstitielle, chacune étant une caractéristique marquante des rats en insuffisance rénale chronique. La sclérose glomérulaire était notable chez les rats en insuffisance rénale chronique. Ces rats avaient des touffes glomérulaires de plus petites dimensions que les rats contrôles quel que soit leur apport protéique. Nous concluons qu'un apport protéique élevé accélère l'évolution de l'insuffisance rénale chronique chez les rats. Le processus pathologique met enjeu une sclérose glomérulaire; cependant, l'inflammation interstitielle et les changements tubulaire s rénaux aboutissant à la formation des kystes semblent également influencer le processus de façon défavorable.</description><identifier>ISSN: 0085-2538</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1038/ki.1985.74</identifier><identifier>PMID: 4021308</identifier><identifier>CODEN: KDYIA5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Blood Urea Nitrogen ; Creatinine - blood ; Creatinine - urine ; Dietary Proteins - pharmacology ; Kidney - anatomy & histology ; Kidney - physiology ; Kidney - ultrastructure ; Male ; Medical sciences ; Microscopy, Electron, Scanning ; Nephrectomy ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Proteinuria ; Rats ; Rats, Inbred Strains ; Renal failure</subject><ispartof>Kidney international, 1985-05, Vol.27 (5), p.739-750</ispartof><rights>1985 International Society of Nephrology</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-85bd9841b1fd1a4e969d3097fec6168211b9cb031a0099b4931739389d33081d3</citedby><cites>FETCH-LOGICAL-c458t-85bd9841b1fd1a4e969d3097fec6168211b9cb031a0099b4931739389d33081d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8452208$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4021308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kenner, Charles H.</creatorcontrib><creatorcontrib>Evan, Andrew P.</creatorcontrib><creatorcontrib>Blomgren, Phillip</creatorcontrib><creatorcontrib>Aronoff, George R.</creatorcontrib><creatorcontrib>Luft, Friedrich C.</creatorcontrib><title>Effect of protein intake on renal function and structure in partially nephrectomized rats</title><title>Kidney international</title><addtitle>Kidney Int</addtitle><description>Effects of protein intake on renal function and structure in partially nephrectomized rats. To examine the effect of high protein intake on renal function and structure in rats with 5/6 nephrectomy chronic renal failure, we pairfed rats with chronic renal failure and sham-operated control rats diets of 14 or 37% protein content for up to 6 months. High protein intake accelerated mortality in rats with chronic renal failure and resulted in a more rapid rate of decrease in renal function as established by plotting the reciprocal of plasma creatinine versus time. High protein intake also increased urine protein excretion in experimental and control rats. High protein intake was associated with increased tubular dilatation and interstitial inflammation, both of which were striking features in rats with chronic renal failure. Glomerular sclerosis was prominent in rats with chronic renal failure. These rats had smaller glomerular tuft dimensions than control rats irrespective of their protein intake. We conclude that high protein intake accelerates the course of chronic renal failure in rats. The pathologic process involves glomerular sclerosis; however, interstitial inflammation and renal tubular changes leading to cyst formation also appear to influence the process adversely.
Effet de l'apport protéique sur la fonction et la structure rénales de rats partiellement néphrectomisés. Afin d'examiner l'effet d'un apport protéique élevé sur la fonction et la structure rénales de rats en insuffisance rénale chronique par néphrectomie des 5/6e, nous avons nourri de façon appariée des rats ayant subi un simulacre d'intervention avec des régimes contenant 14 ou 37% de protéines pendant 6 mois. Le fort apport protéique a accéléré la mortalité des rats en insuffisance rénale chronique et a entrainé une plus rapide vitesse de décroissance de la fonction rénale, établie en représentant l'inverse de la créatininémie en fonction du temps. Le fort apport protéique a également augmenté l'excrétion urinaire de protéines chez les rats contrôles et expérimentaux. Le fort apport protéique était associé à une augmentation de la dilatation tubulaire, et de l'inflammation interstitielle, chacune étant une caractéristique marquante des rats en insuffisance rénale chronique. La sclérose glomérulaire était notable chez les rats en insuffisance rénale chronique. Ces rats avaient des touffes glomérulaires de plus petites dimensions que les rats contrôles quel que soit leur apport protéique. Nous concluons qu'un apport protéique élevé accélère l'évolution de l'insuffisance rénale chronique chez les rats. Le processus pathologique met enjeu une sclérose glomérulaire; cependant, l'inflammation interstitielle et les changements tubulaire s rénaux aboutissant à la formation des kystes semblent également influencer le processus de façon défavorable.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Urea Nitrogen</subject><subject>Creatinine - blood</subject><subject>Creatinine - urine</subject><subject>Dietary Proteins - pharmacology</subject><subject>Kidney - anatomy & histology</subject><subject>Kidney - physiology</subject><subject>Kidney - ultrastructure</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>Nephrectomy</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Proteinuria</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Renal failure</subject><issn>0085-2538</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkD1rHDEQhoWJcS62m_QBFcFFYM_6vJXKYOzEcODGLlwJrTSLldvTXiRt4Pzro_MtrlwNwzy8M_Mg9JWSJSVcXW_Ckmoll604QQsqGW9oK-UntCBEyYZJrj6jLzn_IbXXnJyhM0EY5UQt0PNt34MreOzxLo0FQsQhFrsBPEacINoB91N0JdTWRo9zSZMrU4KK4Z1NJdhh2OMIu5dUc8ZteAWPky35Ap32dshwOddz9HR3-3jzu1k__Lq_-blunJCqNEp2XitBO9p7agXolfac6LZetaIrxSjttOsIp5YQrTuhOW255qpS9QHq-Tm6OubW-_9OkIvZhuxgGGyEccqmXTEmmSYV_HEEXRpzTtCbXQpbm_aGEnPwaDbBHDyaVlT425w6dVvw7-gsrs6_z3ObnR36ZKML-R1TQjL2hokjBtXAvwDJZBcgOvDhoMv4MXy0_T9KWYvy</recordid><startdate>198505</startdate><enddate>198505</enddate><creator>Kenner, Charles H.</creator><creator>Evan, Andrew P.</creator><creator>Blomgren, Phillip</creator><creator>Aronoff, George R.</creator><creator>Luft, Friedrich C.</creator><general>Elsevier Inc</general><general>Nature Publishing</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198505</creationdate><title>Effect of protein intake on renal function and structure in partially nephrectomized rats</title><author>Kenner, Charles H. ; Evan, Andrew P. ; Blomgren, Phillip ; Aronoff, George R. ; Luft, Friedrich C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-85bd9841b1fd1a4e969d3097fec6168211b9cb031a0099b4931739389d33081d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Urea Nitrogen</topic><topic>Creatinine - blood</topic><topic>Creatinine - urine</topic><topic>Dietary Proteins - pharmacology</topic><topic>Kidney - anatomy & histology</topic><topic>Kidney - physiology</topic><topic>Kidney - ultrastructure</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microscopy, Electron, Scanning</topic><topic>Nephrectomy</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Proteinuria</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Renal failure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kenner, Charles H.</creatorcontrib><creatorcontrib>Evan, Andrew P.</creatorcontrib><creatorcontrib>Blomgren, Phillip</creatorcontrib><creatorcontrib>Aronoff, George R.</creatorcontrib><creatorcontrib>Luft, Friedrich C.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Kidney international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kenner, Charles H.</au><au>Evan, Andrew P.</au><au>Blomgren, Phillip</au><au>Aronoff, George R.</au><au>Luft, Friedrich C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of protein intake on renal function and structure in partially nephrectomized rats</atitle><jtitle>Kidney international</jtitle><addtitle>Kidney Int</addtitle><date>1985-05</date><risdate>1985</risdate><volume>27</volume><issue>5</issue><spage>739</spage><epage>750</epage><pages>739-750</pages><issn>0085-2538</issn><eissn>1523-1755</eissn><coden>KDYIA5</coden><abstract>Effects of protein intake on renal function and structure in partially nephrectomized rats. To examine the effect of high protein intake on renal function and structure in rats with 5/6 nephrectomy chronic renal failure, we pairfed rats with chronic renal failure and sham-operated control rats diets of 14 or 37% protein content for up to 6 months. High protein intake accelerated mortality in rats with chronic renal failure and resulted in a more rapid rate of decrease in renal function as established by plotting the reciprocal of plasma creatinine versus time. High protein intake also increased urine protein excretion in experimental and control rats. High protein intake was associated with increased tubular dilatation and interstitial inflammation, both of which were striking features in rats with chronic renal failure. Glomerular sclerosis was prominent in rats with chronic renal failure. These rats had smaller glomerular tuft dimensions than control rats irrespective of their protein intake. We conclude that high protein intake accelerates the course of chronic renal failure in rats. The pathologic process involves glomerular sclerosis; however, interstitial inflammation and renal tubular changes leading to cyst formation also appear to influence the process adversely.
Effet de l'apport protéique sur la fonction et la structure rénales de rats partiellement néphrectomisés. Afin d'examiner l'effet d'un apport protéique élevé sur la fonction et la structure rénales de rats en insuffisance rénale chronique par néphrectomie des 5/6e, nous avons nourri de façon appariée des rats ayant subi un simulacre d'intervention avec des régimes contenant 14 ou 37% de protéines pendant 6 mois. Le fort apport protéique a accéléré la mortalité des rats en insuffisance rénale chronique et a entrainé une plus rapide vitesse de décroissance de la fonction rénale, établie en représentant l'inverse de la créatininémie en fonction du temps. Le fort apport protéique a également augmenté l'excrétion urinaire de protéines chez les rats contrôles et expérimentaux. Le fort apport protéique était associé à une augmentation de la dilatation tubulaire, et de l'inflammation interstitielle, chacune étant une caractéristique marquante des rats en insuffisance rénale chronique. La sclérose glomérulaire était notable chez les rats en insuffisance rénale chronique. Ces rats avaient des touffes glomérulaires de plus petites dimensions que les rats contrôles quel que soit leur apport protéique. Nous concluons qu'un apport protéique élevé accélère l'évolution de l'insuffisance rénale chronique chez les rats. Le processus pathologique met enjeu une sclérose glomérulaire; cependant, l'inflammation interstitielle et les changements tubulaire s rénaux aboutissant à la formation des kystes semblent également influencer le processus de façon défavorable.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>4021308</pmid><doi>10.1038/ki.1985.74</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological and medical sciences Blood Urea Nitrogen Creatinine - blood Creatinine - urine Dietary Proteins - pharmacology Kidney - anatomy & histology Kidney - physiology Kidney - ultrastructure Male Medical sciences Microscopy, Electron, Scanning Nephrectomy Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Proteinuria Rats Rats, Inbred Strains Renal failure |
| title | Effect of protein intake on renal function and structure in partially nephrectomized rats |
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