Influence of Age and Gender on the In Vitro Serum Protein Binding of Flecainide
The in vitro protein binding of flecainide was studied by equilibrium dialysis in relation to serum concentrations of albumin and alpha 1-acid glycoprotein (AAG) in 22 healthy subjects of both sexes aged between 23 and 89 years. In the range of flecainide concentrations tested, protein binding of fl...
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| Veröffentlicht in: | Pharmacological research 1993-10, Vol.28 (3), p.259-264 |
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| container_title | Pharmacological research |
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| creator | Zordan, R. Padrini, R. Bernini, V. Piovan, D. Ferrari, M. |
| description | The
in vitro protein binding of flecainide was studied by equilibrium dialysis in relation to serum concentrations of albumin and alpha
1-acid glycoprotein (AAG) in 22 healthy subjects of both sexes aged between 23 and 89 years.
In the range of flecainide concentrations tested, protein binding of flecainide was not saturable and the percent value of the unbound fraction ranged between 0.48 and 0.68, mean value (SD)=0.59 (±0.06), without any significant difference between males and females or between young and old subjects. The flecainide unbound fraction was significantly correlated with serum albumin concentrations but not with total serum proteins or AAG concentrations. |
| doi_str_mv | 10.1006/phrs.1993.1129 |
| format | Article |
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in vitro protein binding of flecainide was studied by equilibrium dialysis in relation to serum concentrations of albumin and alpha
1-acid glycoprotein (AAG) in 22 healthy subjects of both sexes aged between 23 and 89 years.
In the range of flecainide concentrations tested, protein binding of flecainide was not saturable and the percent value of the unbound fraction ranged between 0.48 and 0.68, mean value (SD)=0.59 (±0.06), without any significant difference between males and females or between young and old subjects. The flecainide unbound fraction was significantly correlated with serum albumin concentrations but not with total serum proteins or AAG concentrations.</description><identifier>ISSN: 1043-6618</identifier><identifier>EISSN: 1096-1186</identifier><identifier>DOI: 10.1006/phrs.1993.1129</identifier><identifier>PMID: 8108316</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Aging - blood ; Antiarythmic agents ; Biological and medical sciences ; Blood Proteins - metabolism ; Cardiovascular system ; Dialysis ; Electrophoresis, Polyacrylamide Gel ; Female ; Flecainide - blood ; flecainide, serum protein binding ; Humans ; Male ; Medical sciences ; Middle Aged ; Orosomucoid - metabolism ; Pharmacology. Drug treatments ; Protein Binding ; Serum Albumin - metabolism ; Sex Characteristics</subject><ispartof>Pharmacological research, 1993-10, Vol.28 (3), p.259-264</ispartof><rights>1993 Academic Press</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-d80e5682736a74ccc03bc9bd295913f86cdad8915b0f86648d14c950520de6e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/phrs.1993.1129$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3848123$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8108316$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zordan, R.</creatorcontrib><creatorcontrib>Padrini, R.</creatorcontrib><creatorcontrib>Bernini, V.</creatorcontrib><creatorcontrib>Piovan, D.</creatorcontrib><creatorcontrib>Ferrari, M.</creatorcontrib><title>Influence of Age and Gender on the In Vitro Serum Protein Binding of Flecainide</title><title>Pharmacological research</title><addtitle>Pharmacol Res</addtitle><description>The
in vitro protein binding of flecainide was studied by equilibrium dialysis in relation to serum concentrations of albumin and alpha
1-acid glycoprotein (AAG) in 22 healthy subjects of both sexes aged between 23 and 89 years.
In the range of flecainide concentrations tested, protein binding of flecainide was not saturable and the percent value of the unbound fraction ranged between 0.48 and 0.68, mean value (SD)=0.59 (±0.06), without any significant difference between males and females or between young and old subjects. The flecainide unbound fraction was significantly correlated with serum albumin concentrations but not with total serum proteins or AAG concentrations.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging - blood</subject><subject>Antiarythmic agents</subject><subject>Biological and medical sciences</subject><subject>Blood Proteins - metabolism</subject><subject>Cardiovascular system</subject><subject>Dialysis</subject><subject>Electrophoresis, Polyacrylamide Gel</subject><subject>Female</subject><subject>Flecainide - blood</subject><subject>flecainide, serum protein binding</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Orosomucoid - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Protein Binding</subject><subject>Serum Albumin - metabolism</subject><subject>Sex Characteristics</subject><issn>1043-6618</issn><issn>1096-1186</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFLAzEQRoMoWqtXb0IO4m1rZrObJscqthYKFRSvIU1mNbLN1mRX8N-7S4s3TzPD92YYHiFXwCbAmLjbfcQ0AaX4BCBXR2QETIkMQIrjoS94JgTIM3Ke0idjTBXATsmpBCY5iBFZL0NVdxgs0qais3ekJji6wOAw0ibQ9gPpMtA338aGvmDstvQ5Ni36QO99cD68D3vzGq3xwTu8ICeVqRNeHuqYvM4fXx-estV6sXyYrTLLhWwzJxmWQuZTLsy0sNYyvrFq43JVKuCVFNYZJxWUG9YPopAOCqtKVubMoUA-Jrf7s7vYfHWYWr31yWJdm4BNl_RU5HkhuerByR60sUkpYqV30W9N_NHA9CBQDwL1IFAPAvuF68PlbrNF94cfjPX5zSE3yZq6iiZYn_4wLgsJOe8xucewl_DtMepk_aDZ-Yi21a7x_33wC9zzinw</recordid><startdate>19931001</startdate><enddate>19931001</enddate><creator>Zordan, R.</creator><creator>Padrini, R.</creator><creator>Bernini, V.</creator><creator>Piovan, D.</creator><creator>Ferrari, M.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19931001</creationdate><title>Influence of Age and Gender on the In Vitro Serum Protein Binding of Flecainide</title><author>Zordan, R. ; Padrini, R. ; Bernini, V. ; Piovan, D. ; Ferrari, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-d80e5682736a74ccc03bc9bd295913f86cdad8915b0f86648d14c950520de6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging - blood</topic><topic>Antiarythmic agents</topic><topic>Biological and medical sciences</topic><topic>Blood Proteins - metabolism</topic><topic>Cardiovascular system</topic><topic>Dialysis</topic><topic>Electrophoresis, Polyacrylamide Gel</topic><topic>Female</topic><topic>Flecainide - blood</topic><topic>flecainide, serum protein binding</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Orosomucoid - metabolism</topic><topic>Pharmacology. Drug treatments</topic><topic>Protein Binding</topic><topic>Serum Albumin - metabolism</topic><topic>Sex Characteristics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zordan, R.</creatorcontrib><creatorcontrib>Padrini, R.</creatorcontrib><creatorcontrib>Bernini, V.</creatorcontrib><creatorcontrib>Piovan, D.</creatorcontrib><creatorcontrib>Ferrari, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmacological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zordan, R.</au><au>Padrini, R.</au><au>Bernini, V.</au><au>Piovan, D.</au><au>Ferrari, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Age and Gender on the In Vitro Serum Protein Binding of Flecainide</atitle><jtitle>Pharmacological research</jtitle><addtitle>Pharmacol Res</addtitle><date>1993-10-01</date><risdate>1993</risdate><volume>28</volume><issue>3</issue><spage>259</spage><epage>264</epage><pages>259-264</pages><issn>1043-6618</issn><eissn>1096-1186</eissn><abstract>The
in vitro protein binding of flecainide was studied by equilibrium dialysis in relation to serum concentrations of albumin and alpha
1-acid glycoprotein (AAG) in 22 healthy subjects of both sexes aged between 23 and 89 years.
In the range of flecainide concentrations tested, protein binding of flecainide was not saturable and the percent value of the unbound fraction ranged between 0.48 and 0.68, mean value (SD)=0.59 (±0.06), without any significant difference between males and females or between young and old subjects. The flecainide unbound fraction was significantly correlated with serum albumin concentrations but not with total serum proteins or AAG concentrations.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>8108316</pmid><doi>10.1006/phrs.1993.1129</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1043-6618 |
| ispartof | Pharmacological research, 1993-10, Vol.28 (3), p.259-264 |
| issn | 1043-6618 1096-1186 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Aged Aged, 80 and over Aging - blood Antiarythmic agents Biological and medical sciences Blood Proteins - metabolism Cardiovascular system Dialysis Electrophoresis, Polyacrylamide Gel Female Flecainide - blood flecainide, serum protein binding Humans Male Medical sciences Middle Aged Orosomucoid - metabolism Pharmacology. Drug treatments Protein Binding Serum Albumin - metabolism Sex Characteristics |
| title | Influence of Age and Gender on the In Vitro Serum Protein Binding of Flecainide |
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