Controlled-Release Preparation of Indomethacin Using Calcium Alginate Gel

Alginate gel beads containing indomethacin (IMC) were prepared using a gelation of alginate with calcium cation. Though IMC was not released from the beads at pH 1.2 because of its extremely low solubility in aqueous media, it was released according to the swelling of alginate gel at pH 6.8. The rel...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 1993/11/15, Vol.16(11), pp.1164-1168
Hauptverfasser:	SHIRAISHI, Sumihiro, IMAI, Teruko, OTAGIRI, Masaki
Format:	Artikel
Sprache:	eng
Schlagworte:	acidic drug Administration, Oral Adult alginate Alginates - chemistry Animals Biological and medical sciences Chromatography, High Pressure Liquid controlled-release Delayed-Action Preparations Dogs Drug Carriers gel bead Gels General pharmacology Glucuronic Acid Hexuronic Acids Humans indomethacin Indomethacin - administration & dosage Indomethacin - blood Indomethacin - pharmacokinetics Intestinal Absorption Male Medical sciences Molecular Weight Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Solubility swelling
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