Behavioural sensitivity to PIA in selectively bred mice is related to a number of A1 adenosine receptors but not to cyclic AMP accumulation in brain slices

In a dose of 0.1 mg/kg, PIA had marked behavioural effects in long-sleep mice (which show a high sensitivity to ethanol, while no significant effect was observed in short sleep mice (low sensitivity to ethanol). The number of [3H]PIA binding sites in cortex and subcortical brain regions was signific...

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Veröffentlicht in:	European journal of pharmacology 1985-04, Vol.111 (1), p.133-136
Hauptverfasser:	FREDHOLM, B. B, ZAHNISER, N. R, WEINER, G. R, PROCTOR, W. R, DUNWIDDIE, T. V
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine Adenosine - analogs & derivatives adenosine A1 Animals Behavior, Animal - drug effects Biological and medical sciences brain Brain - drug effects Brain - metabolism Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Cerebellum - metabolism Cerebral Cortex - metabolism Cyclic AMP - metabolism Ethanol - pharmacology Fundamental and applied biological sciences. Psychology Hippocampus - metabolism Mice Phenylisopropyladenosine - metabolism Phenylisopropyladenosine - pharmacology Receptors, Cell Surface - drug effects Receptors, Cell Surface - metabolism Receptors, Purinergic sleep Sleep - drug effects Sleep - physiology Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
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