The influence of verapamil on the gastric effects of stress in rats
The influence of verapamil on stress- or bethanechol-induced gastric effects was investigated in rats. Intraperitoneally injected verapamil (1, 2 or 4 mg/kg), given 30 min beforehand, dose-dependently prevented gastric glandular ulceration, mast cell degranulation and the increased stomach wall cont...
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| Veröffentlicht in: | European journal of pharmacology 1985-06, Vol.112 (3), p.399-404 |
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| container_title | European journal of pharmacology |
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| creator | Ogle, Clive W. Cho, Chi H. Tong, Man C. Koo, Marcel W.L. |
| description | The influence of verapamil on stress- or bethanechol-induced gastric effects was investigated in rats. Intraperitoneally injected verapamil (1, 2 or 4 mg/kg), given 30 min beforehand, dose-dependently prevented gastric glandular ulceration, mast cell degranulation and the increased stomach wall contractions evoked by restraint at 4°C for 1 h. Gastric acid secretion, as well as ulceration in both the forestomach and glandular segment, produced by subcutaneously-injected bethanechol (3.2 mg/kg) were also inhibited. It is concluded that decreased amine release from the mast cells, stomach wall relaxation and reduced gastric acid were responsible for the ulcer-antagonising effects of the calcium-entry blocker. The possible antiulcer actions of verapamil are discussed in the light of present knowledge regarding calcium involvement in the various mechanisms thought to contribute to the pathophysiology of stress ulceration in rat stomachs. |
| doi_str_mv | 10.1016/0014-2999(85)90787-3 |
| format | Article |
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Intraperitoneally injected verapamil (1, 2 or 4 mg/kg), given 30 min beforehand, dose-dependently prevented gastric glandular ulceration, mast cell degranulation and the increased stomach wall contractions evoked by restraint at 4°C for 1 h. Gastric acid secretion, as well as ulceration in both the forestomach and glandular segment, produced by subcutaneously-injected bethanechol (3.2 mg/kg) were also inhibited. It is concluded that decreased amine release from the mast cells, stomach wall relaxation and reduced gastric acid were responsible for the ulcer-antagonising effects of the calcium-entry blocker. The possible antiulcer actions of verapamil are discussed in the light of present knowledge regarding calcium involvement in the various mechanisms thought to contribute to the pathophysiology of stress ulceration in rat stomachs.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(85)90787-3</identifier><identifier>PMID: 4040471</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Bethanechol Compounds ; Bethanechol-induced gastric secretion ; Biological and medical sciences ; Digestive system ; Female ; Gastric Mucosa - drug effects ; Gastric ulcers and mast cells ; Humans ; Mast Cells - drug effects ; Medical sciences ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Strains ; Stomach contractions ; Stomach Ulcer - etiology ; Stomach Ulcer - prevention & control ; Stress ; Stress, Psychological - complications ; Verapamil ; Verapamil - therapeutic use</subject><ispartof>European journal of pharmacology, 1985-06, Vol.112 (3), p.399-404</ispartof><rights>1985</rights><rights>1986 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-24fc4af497c2db6fc5f9bfa2d6157402141c10256ae487af0a4e07352a22573a3</citedby><cites>FETCH-LOGICAL-c483t-24fc4af497c2db6fc5f9bfa2d6157402141c10256ae487af0a4e07352a22573a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0014299985907873$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8432130$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4040471$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogle, Clive W.</creatorcontrib><creatorcontrib>Cho, Chi H.</creatorcontrib><creatorcontrib>Tong, Man C.</creatorcontrib><creatorcontrib>Koo, Marcel W.L.</creatorcontrib><title>The influence of verapamil on the gastric effects of stress in rats</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The influence of verapamil on stress- or bethanechol-induced gastric effects was investigated in rats. Intraperitoneally injected verapamil (1, 2 or 4 mg/kg), given 30 min beforehand, dose-dependently prevented gastric glandular ulceration, mast cell degranulation and the increased stomach wall contractions evoked by restraint at 4°C for 1 h. Gastric acid secretion, as well as ulceration in both the forestomach and glandular segment, produced by subcutaneously-injected bethanechol (3.2 mg/kg) were also inhibited. It is concluded that decreased amine release from the mast cells, stomach wall relaxation and reduced gastric acid were responsible for the ulcer-antagonising effects of the calcium-entry blocker. The possible antiulcer actions of verapamil are discussed in the light of present knowledge regarding calcium involvement in the various mechanisms thought to contribute to the pathophysiology of stress ulceration in rat stomachs.</description><subject>Animals</subject><subject>Bethanechol Compounds</subject><subject>Bethanechol-induced gastric secretion</subject><subject>Biological and medical sciences</subject><subject>Digestive system</subject><subject>Female</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastric ulcers and mast cells</subject><subject>Humans</subject><subject>Mast Cells - drug effects</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Stomach contractions</subject><subject>Stomach Ulcer - etiology</subject><subject>Stomach Ulcer - prevention & control</subject><subject>Stress</subject><subject>Stress, Psychological - complications</subject><subject>Verapamil</subject><subject>Verapamil - therapeutic use</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1LAzEURYMoWqv_QGEWIroYzedkZiNI8QsKbuo6vGZeNDKdqcm04L83Y0uXShaB3HMfjxNCzhi9YZQVt5QymfOqqq5KdV1RXepc7JERK3WVU834PhntkCNyHOMnpVRVXB2SQ0nT0WxEJrMPzHzrmhW2FrPOZWsMsISFb7KuzfqUvkPsg7cZOoe2jwOTHjDG1MsC9PGEHDhoIp5u7zF5e3yYTZ7z6evTy-R-mltZij7n0lkJTlba8npeOKtcNXfA64IpLSlnkllGuSoAZanBUZBItVAcOFdagBiTy83cZei-Vhh7s_DRYtNAi90qGl1wphXX_4JMFroQJUug3IA2dDEGdGYZ_ALCt2HUDJLNYNAMBk2pzK9kI1LtfDt_NV9gvSttrab8YptDtNC4AK31cYeVUnAmaMLuNhgmaWuPwUTrh2-ofUimTd35v_f4Aa0Wlns</recordid><startdate>19850619</startdate><enddate>19850619</enddate><creator>Ogle, Clive W.</creator><creator>Cho, Chi H.</creator><creator>Tong, Man C.</creator><creator>Koo, Marcel W.L.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>19850619</creationdate><title>The influence of verapamil on the gastric effects of stress in rats</title><author>Ogle, Clive W. ; Cho, Chi H. ; Tong, Man C. ; Koo, Marcel W.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-24fc4af497c2db6fc5f9bfa2d6157402141c10256ae487af0a4e07352a22573a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Animals</topic><topic>Bethanechol Compounds</topic><topic>Bethanechol-induced gastric secretion</topic><topic>Biological and medical sciences</topic><topic>Digestive system</topic><topic>Female</topic><topic>Gastric Mucosa - drug effects</topic><topic>Gastric ulcers and mast cells</topic><topic>Humans</topic><topic>Mast Cells - drug effects</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Stomach contractions</topic><topic>Stomach Ulcer - etiology</topic><topic>Stomach Ulcer - prevention & control</topic><topic>Stress</topic><topic>Stress, Psychological - complications</topic><topic>Verapamil</topic><topic>Verapamil - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ogle, Clive W.</creatorcontrib><creatorcontrib>Cho, Chi H.</creatorcontrib><creatorcontrib>Tong, Man C.</creatorcontrib><creatorcontrib>Koo, Marcel W.L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogle, Clive W.</au><au>Cho, Chi H.</au><au>Tong, Man C.</au><au>Koo, Marcel W.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of verapamil on the gastric effects of stress in rats</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1985-06-19</date><risdate>1985</risdate><volume>112</volume><issue>3</issue><spage>399</spage><epage>404</epage><pages>399-404</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>The influence of verapamil on stress- or bethanechol-induced gastric effects was investigated in rats. Intraperitoneally injected verapamil (1, 2 or 4 mg/kg), given 30 min beforehand, dose-dependently prevented gastric glandular ulceration, mast cell degranulation and the increased stomach wall contractions evoked by restraint at 4°C for 1 h. Gastric acid secretion, as well as ulceration in both the forestomach and glandular segment, produced by subcutaneously-injected bethanechol (3.2 mg/kg) were also inhibited. It is concluded that decreased amine release from the mast cells, stomach wall relaxation and reduced gastric acid were responsible for the ulcer-antagonising effects of the calcium-entry blocker. The possible antiulcer actions of verapamil are discussed in the light of present knowledge regarding calcium involvement in the various mechanisms thought to contribute to the pathophysiology of stress ulceration in rat stomachs.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>4040471</pmid><doi>10.1016/0014-2999(85)90787-3</doi><tpages>6</tpages></addata></record> |
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| ispartof | European journal of pharmacology, 1985-06, Vol.112 (3), p.399-404 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Bethanechol Compounds Bethanechol-induced gastric secretion Biological and medical sciences Digestive system Female Gastric Mucosa - drug effects Gastric ulcers and mast cells Humans Mast Cells - drug effects Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred Strains Stomach contractions Stomach Ulcer - etiology Stomach Ulcer - prevention & control Stress Stress, Psychological - complications Verapamil Verapamil - therapeutic use |
| title | The influence of verapamil on the gastric effects of stress in rats |
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