Analgesic effects of cyclazocine and morphine microinjected into the rat dorsomedial hypothalamus demonstrated by the bradykinin-induced flexor reflex test

The analgesic effect of cyclazocine microinjected into the diencephalon of rats was studied by using the bradykinin-induced flexor reflex test. The dorsal portion of the medial hypothalamic area was sensitive to cyclazocine with respect to the production of analgesia (ED 50 2.6 μg/rat). Microinjecti...

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Veröffentlicht in:	European journal of pharmacology 1985-01, Vol.111 (1), p.117-120
Hauptverfasser:	Kawajiri, Shin-Ichi, Satoh, Masamichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesic Analgesics Animals Biological and medical sciences Bradykinin - pharmacology Bradykinin-induced Cyclazocine Cyclazocine - pharmacology Dorsomedial Hypothalamic Nucleus - drug effects Dorsomedial hypothalamus Hypothalamus, Middle - drug effects Male Medical sciences Morphine Morphine - pharmacology Neuropharmacology Nociceptors - drug effects Pain - physiopathology Pharmacology. Drug treatments Rats Rats, Inbred Strains Reflex - drug effects
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