Quantitative Studies of Human Lung Airspace Wall in Relation to Collagen and Elastin Content
Biochemical determinations of the collagen and elastin content in 50 mm3 samples of human lung are presented in relation to morphometric measurements of lung structure, as the amount of alveolar wall surface area per unit volume (A WUV), on adjacent slices. There were no differences in A WUV values,...
Gespeichert in:
| Veröffentlicht in: | Matrix (Stuttgart) 1993-11, Vol.13 (6), p.471-480 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 480 |
|---|---|
| container_issue | 6 |
| container_start_page | 471 |
| container_title | Matrix (Stuttgart) |
| container_volume | 13 |
| creator | Lang, Malcolm R. Fiaux, Gerald W. Hulmes, David J.S. Lams, David Miller, Andrew |
| description | Biochemical determinations of the collagen and elastin content in 50 mm3 samples of human lung are presented in relation to morphometric measurements of lung structure, as the amount of alveolar wall surface area per unit volume (A WUV), on adjacent slices. There were no differences in A WUV values, collagen content (determined as hydroxyproline) or elastin content (determined as isodesmosine) between upper and lower lobes within a single lung. In a study of 102 samples from 9 smokers lungs with no evidence of macro- or microscopic emphysema (as estimated by A WUV measurement), there was a negative correlation between A WUV and the amounts of collagen or elastin per unit volume of inflated lung. The correlation was stronger when collagen and elastin content were expressed per unit area of alveolar wall. The negative correlation is interpreted as representing either the anatomical variation within the complex hierarchy of normal lung structure or possibly low levels of fibrosis in response to cigarette smoking. |
| doi_str_mv | 10.1016/S0934-8832(11)80113-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76216105</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0934883211801137</els_id><sourcerecordid>76216105</sourcerecordid><originalsourceid>FETCH-LOGICAL-c389t-23007a5cb4025c5756e0e6bec3fd312d32963458194ee3e2da4aa8b65a926f03</originalsourceid><addsrcrecordid>eNqFkEtrGzEQgHVoSU2SnxDQIYT2sI0eu1rtKQST1gFDaBPopSDG2lmjsJZcSWvIv68cG18zFw2abx58hFxx9p0zrm6fWSfrSmspvnL-TTPOZdV-IrPT9xdymdIrK9HVrK75GTnTsuRCzcjfXxP47DJkt0P6nKfeYaJhoItpA54uJ7-m9y6mLVikf2AcqfP0N46FD57mQOdhHGGNnoLv6cMIKRdgHnxGny_I5wHGhJfH95y8_Hh4mS-q5dPPx_n9srJSd7kSkrEWGruqmWhs0zYKGaoVWjn0koteik7JutG8qxElih5qAL1SDXRCDUyek5vD2G0M_yZM2Wxcslju8himZFoluOKsKWBzAG0MKUUczDa6DcQ3w5nZuzTvLs1emuHcvLs0bem7Oi6YVhvsT11Hi6V-faxDsjAOEbx16YTJTnGt9-vvDhgWFzuH0STr0FvsXUSbTR_cB4f8B0wZkVI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76216105</pqid></control><display><type>article</type><title>Quantitative Studies of Human Lung Airspace Wall in Relation to Collagen and Elastin Content</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Lang, Malcolm R. ; Fiaux, Gerald W. ; Hulmes, David J.S. ; Lams, David ; Miller, Andrew</creator><creatorcontrib>Lang, Malcolm R. ; Fiaux, Gerald W. ; Hulmes, David J.S. ; Lams, David ; Miller, Andrew</creatorcontrib><description>Biochemical determinations of the collagen and elastin content in 50 mm3 samples of human lung are presented in relation to morphometric measurements of lung structure, as the amount of alveolar wall surface area per unit volume (A WUV), on adjacent slices. There were no differences in A WUV values, collagen content (determined as hydroxyproline) or elastin content (determined as isodesmosine) between upper and lower lobes within a single lung. In a study of 102 samples from 9 smokers lungs with no evidence of macro- or microscopic emphysema (as estimated by A WUV measurement), there was a negative correlation between A WUV and the amounts of collagen or elastin per unit volume of inflated lung. The correlation was stronger when collagen and elastin content were expressed per unit area of alveolar wall. The negative correlation is interpreted as representing either the anatomical variation within the complex hierarchy of normal lung structure or possibly low levels of fibrosis in response to cigarette smoking.</description><identifier>ISSN: 0934-8832</identifier><identifier>DOI: 10.1016/S0934-8832(11)80113-7</identifier><identifier>PMID: 8309426</identifier><language>eng</language><publisher>Stuttgart: Fischer</publisher><subject>Aged ; Aged, 80 and over ; Air breathing ; Analysis of Variance ; Autopsy ; Biological and medical sciences ; collagen ; Collagen - analysis ; elastin ; Elastin - analysis ; Fundamental and applied biological sciences. Psychology ; Humans ; lung ; Lung - anatomy & histology ; Lung - chemistry ; Lung - pathology ; Middle Aged ; morphometry ; Pulmonary Alveoli - pathology ; Reference Values ; Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics ; Smoking ; Vertebrates: respiratory system</subject><ispartof>Matrix (Stuttgart), 1993-11, Vol.13 (6), p.471-480</ispartof><rights>1993 Gustav Fischer Verlag · Stuttgart · Jena · New York</rights><rights>1994 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-23007a5cb4025c5756e0e6bec3fd312d32963458194ee3e2da4aa8b65a926f03</citedby><cites>FETCH-LOGICAL-c389t-23007a5cb4025c5756e0e6bec3fd312d32963458194ee3e2da4aa8b65a926f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3961885$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8309426$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lang, Malcolm R.</creatorcontrib><creatorcontrib>Fiaux, Gerald W.</creatorcontrib><creatorcontrib>Hulmes, David J.S.</creatorcontrib><creatorcontrib>Lams, David</creatorcontrib><creatorcontrib>Miller, Andrew</creatorcontrib><title>Quantitative Studies of Human Lung Airspace Wall in Relation to Collagen and Elastin Content</title><title>Matrix (Stuttgart)</title><addtitle>Matrix</addtitle><description>Biochemical determinations of the collagen and elastin content in 50 mm3 samples of human lung are presented in relation to morphometric measurements of lung structure, as the amount of alveolar wall surface area per unit volume (A WUV), on adjacent slices. There were no differences in A WUV values, collagen content (determined as hydroxyproline) or elastin content (determined as isodesmosine) between upper and lower lobes within a single lung. In a study of 102 samples from 9 smokers lungs with no evidence of macro- or microscopic emphysema (as estimated by A WUV measurement), there was a negative correlation between A WUV and the amounts of collagen or elastin per unit volume of inflated lung. The correlation was stronger when collagen and elastin content were expressed per unit area of alveolar wall. The negative correlation is interpreted as representing either the anatomical variation within the complex hierarchy of normal lung structure or possibly low levels of fibrosis in response to cigarette smoking.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Air breathing</subject><subject>Analysis of Variance</subject><subject>Autopsy</subject><subject>Biological and medical sciences</subject><subject>collagen</subject><subject>Collagen - analysis</subject><subject>elastin</subject><subject>Elastin - analysis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>lung</subject><subject>Lung - anatomy & histology</subject><subject>Lung - chemistry</subject><subject>Lung - pathology</subject><subject>Middle Aged</subject><subject>morphometry</subject><subject>Pulmonary Alveoli - pathology</subject><subject>Reference Values</subject><subject>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</subject><subject>Smoking</subject><subject>Vertebrates: respiratory system</subject><issn>0934-8832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtrGzEQgHVoSU2SnxDQIYT2sI0eu1rtKQST1gFDaBPopSDG2lmjsJZcSWvIv68cG18zFw2abx58hFxx9p0zrm6fWSfrSmspvnL-TTPOZdV-IrPT9xdymdIrK9HVrK75GTnTsuRCzcjfXxP47DJkt0P6nKfeYaJhoItpA54uJ7-m9y6mLVikf2AcqfP0N46FD57mQOdhHGGNnoLv6cMIKRdgHnxGny_I5wHGhJfH95y8_Hh4mS-q5dPPx_n9srJSd7kSkrEWGruqmWhs0zYKGaoVWjn0koteik7JutG8qxElih5qAL1SDXRCDUyek5vD2G0M_yZM2Wxcslju8himZFoluOKsKWBzAG0MKUUczDa6DcQ3w5nZuzTvLs1emuHcvLs0bem7Oi6YVhvsT11Hi6V-faxDsjAOEbx16YTJTnGt9-vvDhgWFzuH0STr0FvsXUSbTR_cB4f8B0wZkVI</recordid><startdate>19931101</startdate><enddate>19931101</enddate><creator>Lang, Malcolm R.</creator><creator>Fiaux, Gerald W.</creator><creator>Hulmes, David J.S.</creator><creator>Lams, David</creator><creator>Miller, Andrew</creator><general>Fischer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19931101</creationdate><title>Quantitative Studies of Human Lung Airspace Wall in Relation to Collagen and Elastin Content</title><author>Lang, Malcolm R. ; Fiaux, Gerald W. ; Hulmes, David J.S. ; Lams, David ; Miller, Andrew</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-23007a5cb4025c5756e0e6bec3fd312d32963458194ee3e2da4aa8b65a926f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Air breathing</topic><topic>Analysis of Variance</topic><topic>Autopsy</topic><topic>Biological and medical sciences</topic><topic>collagen</topic><topic>Collagen - analysis</topic><topic>elastin</topic><topic>Elastin - analysis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>lung</topic><topic>Lung - anatomy & histology</topic><topic>Lung - chemistry</topic><topic>Lung - pathology</topic><topic>Middle Aged</topic><topic>morphometry</topic><topic>Pulmonary Alveoli - pathology</topic><topic>Reference Values</topic><topic>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</topic><topic>Smoking</topic><topic>Vertebrates: respiratory system</topic><toplevel>online_resources</toplevel><creatorcontrib>Lang, Malcolm R.</creatorcontrib><creatorcontrib>Fiaux, Gerald W.</creatorcontrib><creatorcontrib>Hulmes, David J.S.</creatorcontrib><creatorcontrib>Lams, David</creatorcontrib><creatorcontrib>Miller, Andrew</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Matrix (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lang, Malcolm R.</au><au>Fiaux, Gerald W.</au><au>Hulmes, David J.S.</au><au>Lams, David</au><au>Miller, Andrew</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Quantitative Studies of Human Lung Airspace Wall in Relation to Collagen and Elastin Content</atitle><jtitle>Matrix (Stuttgart)</jtitle><addtitle>Matrix</addtitle><date>1993-11-01</date><risdate>1993</risdate><volume>13</volume><issue>6</issue><spage>471</spage><epage>480</epage><pages>471-480</pages><issn>0934-8832</issn><abstract>Biochemical determinations of the collagen and elastin content in 50 mm3 samples of human lung are presented in relation to morphometric measurements of lung structure, as the amount of alveolar wall surface area per unit volume (A WUV), on adjacent slices. There were no differences in A WUV values, collagen content (determined as hydroxyproline) or elastin content (determined as isodesmosine) between upper and lower lobes within a single lung. In a study of 102 samples from 9 smokers lungs with no evidence of macro- or microscopic emphysema (as estimated by A WUV measurement), there was a negative correlation between A WUV and the amounts of collagen or elastin per unit volume of inflated lung. The correlation was stronger when collagen and elastin content were expressed per unit area of alveolar wall. The negative correlation is interpreted as representing either the anatomical variation within the complex hierarchy of normal lung structure or possibly low levels of fibrosis in response to cigarette smoking.</abstract><cop>Stuttgart</cop><pub>Fischer</pub><pmid>8309426</pmid><doi>10.1016/S0934-8832(11)80113-7</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0934-8832 |
| ispartof | Matrix (Stuttgart), 1993-11, Vol.13 (6), p.471-480 |
| issn | 0934-8832 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76216105 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over Air breathing Analysis of Variance Autopsy Biological and medical sciences collagen Collagen - analysis elastin Elastin - analysis Fundamental and applied biological sciences. Psychology Humans lung Lung - anatomy & histology Lung - chemistry Lung - pathology Middle Aged morphometry Pulmonary Alveoli - pathology Reference Values Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Smoking Vertebrates: respiratory system |
| title | Quantitative Studies of Human Lung Airspace Wall in Relation to Collagen and Elastin Content |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T07%3A19%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Quantitative%20Studies%20of%20Human%20Lung%20Airspace%20Wall%20in%20Relation%20to%20Collagen%20and%20Elastin%20Content&rft.jtitle=Matrix%20(Stuttgart)&rft.au=Lang,%20Malcolm%20R.&rft.date=1993-11-01&rft.volume=13&rft.issue=6&rft.spage=471&rft.epage=480&rft.pages=471-480&rft.issn=0934-8832&rft_id=info:doi/10.1016/S0934-8832(11)80113-7&rft_dat=%3Cproquest_cross%3E76216105%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76216105&rft_id=info:pmid/8309426&rft_els_id=S0934883211801137&rfr_iscdi=true |