Effect of Microelectrophoretically Applied Acetylcholine, Noradrenaline, Dopamine and Serotonin on the Discharge of Paraventricular Oxytocinergic Neurones in the Rat

The effects of microelectrophoretic applications of neurotransmitter substances and their antagonists on the activity of paraventricular oxytocinergic neurones were studied in urethane anesthetized lactating rats. Oxytocinergic neurones were identified by their antidromic response to the stimulation...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Endocrinologia Japonica 1985, Vol.32(1), pp.127-133
Hauptverfasser: HONDA, KAZUMASA, NEGORO, HIDEO, FUKUOKA, TETSUJI, HIGUCHI, TAKASHI, UCHIDE, KIYOSHI
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 133
container_issue 1
container_start_page 127
container_title Endocrinologia Japonica
container_volume 32
creator HONDA, KAZUMASA
NEGORO, HIDEO
FUKUOKA, TETSUJI
HIGUCHI, TAKASHI
UCHIDE, KIYOSHI
description The effects of microelectrophoretic applications of neurotransmitter substances and their antagonists on the activity of paraventricular oxytocinergic neurones were studied in urethane anesthetized lactating rats. Oxytocinergic neurones were identified by their antidromic response to the stimulation of the neurohypophysis and by their characteristic high frequency discharge of action potentials approximately 15-20 s before reflex milk ejection. Acetylcholine (ACh) excited the majority (75%) of paraventricular oxytocinergic neurones, and none of the cells was inhibited in its activity by ACh. In about half of the oxytocinergic cells, atropine and hexamethonium reduced the number of action potentials during the burst discharge preceding reflex milk ejection. Noradrenaline (NE), dopamine (DA) and serotonin (5-HT) reduced the activity of most (75-100%) of oxytocinergic neurones, and none of the cells was excited by these catecholamines. These results suggest that paraventricular oxytocinergic neurones receive excitatory cholinergic inputs and inhibitory noradrenergic, dopaminergic and serotonergic inputs.
doi_str_mv 10.1507/endocrj1954.32.127
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76213078</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>76213078</sourcerecordid><originalsourceid>FETCH-LOGICAL-c429t-91dac598297772dddcc5c2a3cc696e42552b0b7106c46e4db56562b66aa7802f3</originalsourceid><addsrcrecordid>eNplUV2P0zAQtBDoqI77A0hIfkA8XYrtJHbyWN0dB9Jxh_h4jrbOpnXl2sF2EP1B_E9cpaqQ8IPt0czsrnYIec3ZktdMvUfXex12vK2rZSmWXKhnZCF4UxeyVOw5WTDGy0IJ3r4kVzHuWD5SSFWxC3IhGimYKBfkz90woE7UD_Sz0cGjzSj4cesDJqPB2gNdjaM12NOVxnSweuutcXhNH32APqCDGd76Efb5R8H19BsGn7wzjnpH0xbprYl6C2GDx05fIMAvdCkYPVkI9On3IXmdvWFjNH3EKXiHkZrZ-hXSK_JiABvx6vRekh8f7r7ffCwenu4_3aweCl2JNhUt70HXbSNapZTo-17rWgsotZatxErUtVizteJM6irjfl3LWoq1lACqYWIoL8m7ue4Y_M8JY-r2eW60Fhz6KXZKCl4y1WShmIV5ZTEGHLoxmD2EQ8dZd4yn-yeerhRdjieb3pyqT-s99mfLKYzMvz3xEPPmhwBOm3iWNVWpKnHsfT_LdjHBBs88hByYxf86z1ce4Kw4JpFl5V_1DLaV</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76213078</pqid></control><display><type>article</type><title>Effect of Microelectrophoretically Applied Acetylcholine, Noradrenaline, Dopamine and Serotonin on the Discharge of Paraventricular Oxytocinergic Neurones in the Rat</title><source>J-STAGE Free</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>HONDA, KAZUMASA ; NEGORO, HIDEO ; FUKUOKA, TETSUJI ; HIGUCHI, TAKASHI ; UCHIDE, KIYOSHI</creator><creatorcontrib>HONDA, KAZUMASA ; NEGORO, HIDEO ; FUKUOKA, TETSUJI ; HIGUCHI, TAKASHI ; UCHIDE, KIYOSHI</creatorcontrib><description>The effects of microelectrophoretic applications of neurotransmitter substances and their antagonists on the activity of paraventricular oxytocinergic neurones were studied in urethane anesthetized lactating rats. Oxytocinergic neurones were identified by their antidromic response to the stimulation of the neurohypophysis and by their characteristic high frequency discharge of action potentials approximately 15-20 s before reflex milk ejection. Acetylcholine (ACh) excited the majority (75%) of paraventricular oxytocinergic neurones, and none of the cells was inhibited in its activity by ACh. In about half of the oxytocinergic cells, atropine and hexamethonium reduced the number of action potentials during the burst discharge preceding reflex milk ejection. Noradrenaline (NE), dopamine (DA) and serotonin (5-HT) reduced the activity of most (75-100%) of oxytocinergic neurones, and none of the cells was excited by these catecholamines. These results suggest that paraventricular oxytocinergic neurones receive excitatory cholinergic inputs and inhibitory noradrenergic, dopaminergic and serotonergic inputs.</description><identifier>ISSN: 0013-7219</identifier><identifier>EISSN: 2185-6370</identifier><identifier>DOI: 10.1507/endocrj1954.32.127</identifier><identifier>PMID: 2862023</identifier><identifier>CODEN: ECJPAE</identifier><language>eng</language><publisher>Tokyo: The Japan Endocrine Society</publisher><subject>Acetylcholine - pharmacology ; Action Potentials - drug effects ; Animals ; Atropine - pharmacology ; Biological and medical sciences ; Dopamine - pharmacology ; Female ; Fundamental and applied biological sciences. Psychology ; Hexamethonium ; Hexamethonium Compounds - pharmacology ; Hormone metabolism and regulation ; Lactation - drug effects ; Norepinephrine - pharmacology ; Oxytocin - physiology ; Paraventricular Hypothalamic Nucleus - drug effects ; Paraventricular Hypothalamic Nucleus - physiology ; Pregnancy ; Pregnancy. Parturition. Lactation ; Rats ; Serotonin - pharmacology ; Vertebrates: reproduction</subject><ispartof>Endocrinologia Japonica, 1985, Vol.32(1), pp.127-133</ispartof><rights>The Japan Endocrine Society</rights><rights>1986 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-91dac598297772dddcc5c2a3cc696e42552b0b7106c46e4db56562b66aa7802f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=8437428$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2862023$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HONDA, KAZUMASA</creatorcontrib><creatorcontrib>NEGORO, HIDEO</creatorcontrib><creatorcontrib>FUKUOKA, TETSUJI</creatorcontrib><creatorcontrib>HIGUCHI, TAKASHI</creatorcontrib><creatorcontrib>UCHIDE, KIYOSHI</creatorcontrib><title>Effect of Microelectrophoretically Applied Acetylcholine, Noradrenaline, Dopamine and Serotonin on the Discharge of Paraventricular Oxytocinergic Neurones in the Rat</title><title>Endocrinologia Japonica</title><addtitle>Endocrinol Japon</addtitle><description>The effects of microelectrophoretic applications of neurotransmitter substances and their antagonists on the activity of paraventricular oxytocinergic neurones were studied in urethane anesthetized lactating rats. Oxytocinergic neurones were identified by their antidromic response to the stimulation of the neurohypophysis and by their characteristic high frequency discharge of action potentials approximately 15-20 s before reflex milk ejection. Acetylcholine (ACh) excited the majority (75%) of paraventricular oxytocinergic neurones, and none of the cells was inhibited in its activity by ACh. In about half of the oxytocinergic cells, atropine and hexamethonium reduced the number of action potentials during the burst discharge preceding reflex milk ejection. Noradrenaline (NE), dopamine (DA) and serotonin (5-HT) reduced the activity of most (75-100%) of oxytocinergic neurones, and none of the cells was excited by these catecholamines. These results suggest that paraventricular oxytocinergic neurones receive excitatory cholinergic inputs and inhibitory noradrenergic, dopaminergic and serotonergic inputs.</description><subject>Acetylcholine - pharmacology</subject><subject>Action Potentials - drug effects</subject><subject>Animals</subject><subject>Atropine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Dopamine - pharmacology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hexamethonium</subject><subject>Hexamethonium Compounds - pharmacology</subject><subject>Hormone metabolism and regulation</subject><subject>Lactation - drug effects</subject><subject>Norepinephrine - pharmacology</subject><subject>Oxytocin - physiology</subject><subject>Paraventricular Hypothalamic Nucleus - drug effects</subject><subject>Paraventricular Hypothalamic Nucleus - physiology</subject><subject>Pregnancy</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>Rats</subject><subject>Serotonin - pharmacology</subject><subject>Vertebrates: reproduction</subject><issn>0013-7219</issn><issn>2185-6370</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplUV2P0zAQtBDoqI77A0hIfkA8XYrtJHbyWN0dB9Jxh_h4jrbOpnXl2sF2EP1B_E9cpaqQ8IPt0czsrnYIec3ZktdMvUfXex12vK2rZSmWXKhnZCF4UxeyVOw5WTDGy0IJ3r4kVzHuWD5SSFWxC3IhGimYKBfkz90woE7UD_Sz0cGjzSj4cesDJqPB2gNdjaM12NOVxnSweuutcXhNH32APqCDGd76Efb5R8H19BsGn7wzjnpH0xbprYl6C2GDx05fIMAvdCkYPVkI9On3IXmdvWFjNH3EKXiHkZrZ-hXSK_JiABvx6vRekh8f7r7ffCwenu4_3aweCl2JNhUt70HXbSNapZTo-17rWgsotZatxErUtVizteJM6irjfl3LWoq1lACqYWIoL8m7ue4Y_M8JY-r2eW60Fhz6KXZKCl4y1WShmIV5ZTEGHLoxmD2EQ8dZd4yn-yeerhRdjieb3pyqT-s99mfLKYzMvz3xEPPmhwBOm3iWNVWpKnHsfT_LdjHBBs88hByYxf86z1ce4Kw4JpFl5V_1DLaV</recordid><startdate>1985</startdate><enddate>1985</enddate><creator>HONDA, KAZUMASA</creator><creator>NEGORO, HIDEO</creator><creator>FUKUOKA, TETSUJI</creator><creator>HIGUCHI, TAKASHI</creator><creator>UCHIDE, KIYOSHI</creator><general>The Japan Endocrine Society</general><general>Japan Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1985</creationdate><title>Effect of Microelectrophoretically Applied Acetylcholine, Noradrenaline, Dopamine and Serotonin on the Discharge of Paraventricular Oxytocinergic Neurones in the Rat</title><author>HONDA, KAZUMASA ; NEGORO, HIDEO ; FUKUOKA, TETSUJI ; HIGUCHI, TAKASHI ; UCHIDE, KIYOSHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-91dac598297772dddcc5c2a3cc696e42552b0b7106c46e4db56562b66aa7802f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Action Potentials - drug effects</topic><topic>Animals</topic><topic>Atropine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Dopamine - pharmacology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hexamethonium</topic><topic>Hexamethonium Compounds - pharmacology</topic><topic>Hormone metabolism and regulation</topic><topic>Lactation - drug effects</topic><topic>Norepinephrine - pharmacology</topic><topic>Oxytocin - physiology</topic><topic>Paraventricular Hypothalamic Nucleus - drug effects</topic><topic>Paraventricular Hypothalamic Nucleus - physiology</topic><topic>Pregnancy</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>Rats</topic><topic>Serotonin - pharmacology</topic><topic>Vertebrates: reproduction</topic><toplevel>online_resources</toplevel><creatorcontrib>HONDA, KAZUMASA</creatorcontrib><creatorcontrib>NEGORO, HIDEO</creatorcontrib><creatorcontrib>FUKUOKA, TETSUJI</creatorcontrib><creatorcontrib>HIGUCHI, TAKASHI</creatorcontrib><creatorcontrib>UCHIDE, KIYOSHI</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrinologia Japonica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HONDA, KAZUMASA</au><au>NEGORO, HIDEO</au><au>FUKUOKA, TETSUJI</au><au>HIGUCHI, TAKASHI</au><au>UCHIDE, KIYOSHI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Microelectrophoretically Applied Acetylcholine, Noradrenaline, Dopamine and Serotonin on the Discharge of Paraventricular Oxytocinergic Neurones in the Rat</atitle><jtitle>Endocrinologia Japonica</jtitle><addtitle>Endocrinol Japon</addtitle><date>1985</date><risdate>1985</risdate><volume>32</volume><issue>1</issue><spage>127</spage><epage>133</epage><pages>127-133</pages><issn>0013-7219</issn><eissn>2185-6370</eissn><coden>ECJPAE</coden><abstract>The effects of microelectrophoretic applications of neurotransmitter substances and their antagonists on the activity of paraventricular oxytocinergic neurones were studied in urethane anesthetized lactating rats. Oxytocinergic neurones were identified by their antidromic response to the stimulation of the neurohypophysis and by their characteristic high frequency discharge of action potentials approximately 15-20 s before reflex milk ejection. Acetylcholine (ACh) excited the majority (75%) of paraventricular oxytocinergic neurones, and none of the cells was inhibited in its activity by ACh. In about half of the oxytocinergic cells, atropine and hexamethonium reduced the number of action potentials during the burst discharge preceding reflex milk ejection. Noradrenaline (NE), dopamine (DA) and serotonin (5-HT) reduced the activity of most (75-100%) of oxytocinergic neurones, and none of the cells was excited by these catecholamines. These results suggest that paraventricular oxytocinergic neurones receive excitatory cholinergic inputs and inhibitory noradrenergic, dopaminergic and serotonergic inputs.</abstract><cop>Tokyo</cop><pub>The Japan Endocrine Society</pub><pmid>2862023</pmid><doi>10.1507/endocrj1954.32.127</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0013-7219
ispartof Endocrinologia Japonica, 1985, Vol.32(1), pp.127-133
issn 0013-7219
2185-6370
language eng
recordid cdi_proquest_miscellaneous_76213078
source J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects Acetylcholine - pharmacology
Action Potentials - drug effects
Animals
Atropine - pharmacology
Biological and medical sciences
Dopamine - pharmacology
Female
Fundamental and applied biological sciences. Psychology
Hexamethonium
Hexamethonium Compounds - pharmacology
Hormone metabolism and regulation
Lactation - drug effects
Norepinephrine - pharmacology
Oxytocin - physiology
Paraventricular Hypothalamic Nucleus - drug effects
Paraventricular Hypothalamic Nucleus - physiology
Pregnancy
Pregnancy. Parturition. Lactation
Rats
Serotonin - pharmacology
Vertebrates: reproduction
title Effect of Microelectrophoretically Applied Acetylcholine, Noradrenaline, Dopamine and Serotonin on the Discharge of Paraventricular Oxytocinergic Neurones in the Rat
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T09%3A06%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20Microelectrophoretically%20Applied%20Acetylcholine,%20Noradrenaline,%20Dopamine%20and%20Serotonin%20on%20the%20Discharge%20of%20Paraventricular%20Oxytocinergic%20Neurones%20in%20the%20Rat&rft.jtitle=Endocrinologia%20Japonica&rft.au=HONDA,%20KAZUMASA&rft.date=1985&rft.volume=32&rft.issue=1&rft.spage=127&rft.epage=133&rft.pages=127-133&rft.issn=0013-7219&rft.eissn=2185-6370&rft.coden=ECJPAE&rft_id=info:doi/10.1507/endocrj1954.32.127&rft_dat=%3Cproquest_cross%3E76213078%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76213078&rft_id=info:pmid/2862023&rfr_iscdi=true