Effect of Microelectrophoretically Applied Acetylcholine, Noradrenaline, Dopamine and Serotonin on the Discharge of Paraventricular Oxytocinergic Neurones in the Rat
The effects of microelectrophoretic applications of neurotransmitter substances and their antagonists on the activity of paraventricular oxytocinergic neurones were studied in urethane anesthetized lactating rats. Oxytocinergic neurones were identified by their antidromic response to the stimulation...
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Veröffentlicht in: | Endocrinologia Japonica 1985, Vol.32(1), pp.127-133 |
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description | The effects of microelectrophoretic applications of neurotransmitter substances and their antagonists on the activity of paraventricular oxytocinergic neurones were studied in urethane anesthetized lactating rats. Oxytocinergic neurones were identified by their antidromic response to the stimulation of the neurohypophysis and by their characteristic high frequency discharge of action potentials approximately 15-20 s before reflex milk ejection. Acetylcholine (ACh) excited the majority (75%) of paraventricular oxytocinergic neurones, and none of the cells was inhibited in its activity by ACh. In about half of the oxytocinergic cells, atropine and hexamethonium reduced the number of action potentials during the burst discharge preceding reflex milk ejection. Noradrenaline (NE), dopamine (DA) and serotonin (5-HT) reduced the activity of most (75-100%) of oxytocinergic neurones, and none of the cells was excited by these catecholamines. These results suggest that paraventricular oxytocinergic neurones receive excitatory cholinergic inputs and inhibitory noradrenergic, dopaminergic and serotonergic inputs. |
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Oxytocinergic neurones were identified by their antidromic response to the stimulation of the neurohypophysis and by their characteristic high frequency discharge of action potentials approximately 15-20 s before reflex milk ejection. Acetylcholine (ACh) excited the majority (75%) of paraventricular oxytocinergic neurones, and none of the cells was inhibited in its activity by ACh. In about half of the oxytocinergic cells, atropine and hexamethonium reduced the number of action potentials during the burst discharge preceding reflex milk ejection. Noradrenaline (NE), dopamine (DA) and serotonin (5-HT) reduced the activity of most (75-100%) of oxytocinergic neurones, and none of the cells was excited by these catecholamines. These results suggest that paraventricular oxytocinergic neurones receive excitatory cholinergic inputs and inhibitory noradrenergic, dopaminergic and serotonergic inputs.</description><identifier>ISSN: 0013-7219</identifier><identifier>EISSN: 2185-6370</identifier><identifier>DOI: 10.1507/endocrj1954.32.127</identifier><identifier>PMID: 2862023</identifier><identifier>CODEN: ECJPAE</identifier><language>eng</language><publisher>Tokyo: The Japan Endocrine Society</publisher><subject>Acetylcholine - pharmacology ; Action Potentials - drug effects ; Animals ; Atropine - pharmacology ; Biological and medical sciences ; Dopamine - pharmacology ; Female ; Fundamental and applied biological sciences. Psychology ; Hexamethonium ; Hexamethonium Compounds - pharmacology ; Hormone metabolism and regulation ; Lactation - drug effects ; Norepinephrine - pharmacology ; Oxytocin - physiology ; Paraventricular Hypothalamic Nucleus - drug effects ; Paraventricular Hypothalamic Nucleus - physiology ; Pregnancy ; Pregnancy. Parturition. 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Oxytocinergic neurones were identified by their antidromic response to the stimulation of the neurohypophysis and by their characteristic high frequency discharge of action potentials approximately 15-20 s before reflex milk ejection. Acetylcholine (ACh) excited the majority (75%) of paraventricular oxytocinergic neurones, and none of the cells was inhibited in its activity by ACh. In about half of the oxytocinergic cells, atropine and hexamethonium reduced the number of action potentials during the burst discharge preceding reflex milk ejection. Noradrenaline (NE), dopamine (DA) and serotonin (5-HT) reduced the activity of most (75-100%) of oxytocinergic neurones, and none of the cells was excited by these catecholamines. These results suggest that paraventricular oxytocinergic neurones receive excitatory cholinergic inputs and inhibitory noradrenergic, dopaminergic and serotonergic inputs.</description><subject>Acetylcholine - pharmacology</subject><subject>Action Potentials - drug effects</subject><subject>Animals</subject><subject>Atropine - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Dopamine - pharmacology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hexamethonium</subject><subject>Hexamethonium Compounds - pharmacology</subject><subject>Hormone metabolism and regulation</subject><subject>Lactation - drug effects</subject><subject>Norepinephrine - pharmacology</subject><subject>Oxytocin - physiology</subject><subject>Paraventricular Hypothalamic Nucleus - drug effects</subject><subject>Paraventricular Hypothalamic Nucleus - physiology</subject><subject>Pregnancy</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>Rats</subject><subject>Serotonin - pharmacology</subject><subject>Vertebrates: reproduction</subject><issn>0013-7219</issn><issn>2185-6370</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1985</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplUV2P0zAQtBDoqI77A0hIfkA8XYrtJHbyWN0dB9Jxh_h4jrbOpnXl2sF2EP1B_E9cpaqQ8IPt0czsrnYIec3ZktdMvUfXex12vK2rZSmWXKhnZCF4UxeyVOw5WTDGy0IJ3r4kVzHuWD5SSFWxC3IhGimYKBfkz90woE7UD_Sz0cGjzSj4cesDJqPB2gNdjaM12NOVxnSweuutcXhNH32APqCDGd76Efb5R8H19BsGn7wzjnpH0xbprYl6C2GDx05fIMAvdCkYPVkI9On3IXmdvWFjNH3EKXiHkZrZ-hXSK_JiABvx6vRekh8f7r7ffCwenu4_3aweCl2JNhUt70HXbSNapZTo-17rWgsotZatxErUtVizteJM6irjfl3LWoq1lACqYWIoL8m7ue4Y_M8JY-r2eW60Fhz6KXZKCl4y1WShmIV5ZTEGHLoxmD2EQ8dZd4yn-yeerhRdjieb3pyqT-s99mfLKYzMvz3xEPPmhwBOm3iWNVWpKnHsfT_LdjHBBs88hByYxf86z1ce4Kw4JpFl5V_1DLaV</recordid><startdate>1985</startdate><enddate>1985</enddate><creator>HONDA, KAZUMASA</creator><creator>NEGORO, HIDEO</creator><creator>FUKUOKA, TETSUJI</creator><creator>HIGUCHI, TAKASHI</creator><creator>UCHIDE, KIYOSHI</creator><general>The Japan Endocrine Society</general><general>Japan Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1985</creationdate><title>Effect of Microelectrophoretically Applied Acetylcholine, Noradrenaline, Dopamine and Serotonin on the Discharge of Paraventricular Oxytocinergic Neurones in the Rat</title><author>HONDA, KAZUMASA ; NEGORO, HIDEO ; FUKUOKA, TETSUJI ; HIGUCHI, TAKASHI ; UCHIDE, KIYOSHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-91dac598297772dddcc5c2a3cc696e42552b0b7106c46e4db56562b66aa7802f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1985</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Action Potentials - drug effects</topic><topic>Animals</topic><topic>Atropine - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Dopamine - pharmacology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hexamethonium</topic><topic>Hexamethonium Compounds - pharmacology</topic><topic>Hormone metabolism and regulation</topic><topic>Lactation - drug effects</topic><topic>Norepinephrine - pharmacology</topic><topic>Oxytocin - physiology</topic><topic>Paraventricular Hypothalamic Nucleus - drug effects</topic><topic>Paraventricular Hypothalamic Nucleus - physiology</topic><topic>Pregnancy</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>Rats</topic><topic>Serotonin - pharmacology</topic><topic>Vertebrates: reproduction</topic><toplevel>online_resources</toplevel><creatorcontrib>HONDA, KAZUMASA</creatorcontrib><creatorcontrib>NEGORO, HIDEO</creatorcontrib><creatorcontrib>FUKUOKA, TETSUJI</creatorcontrib><creatorcontrib>HIGUCHI, TAKASHI</creatorcontrib><creatorcontrib>UCHIDE, KIYOSHI</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrinologia Japonica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HONDA, KAZUMASA</au><au>NEGORO, HIDEO</au><au>FUKUOKA, TETSUJI</au><au>HIGUCHI, TAKASHI</au><au>UCHIDE, KIYOSHI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Microelectrophoretically Applied Acetylcholine, Noradrenaline, Dopamine and Serotonin on the Discharge of Paraventricular Oxytocinergic Neurones in the Rat</atitle><jtitle>Endocrinologia Japonica</jtitle><addtitle>Endocrinol Japon</addtitle><date>1985</date><risdate>1985</risdate><volume>32</volume><issue>1</issue><spage>127</spage><epage>133</epage><pages>127-133</pages><issn>0013-7219</issn><eissn>2185-6370</eissn><coden>ECJPAE</coden><abstract>The effects of microelectrophoretic applications of neurotransmitter substances and their antagonists on the activity of paraventricular oxytocinergic neurones were studied in urethane anesthetized lactating rats. Oxytocinergic neurones were identified by their antidromic response to the stimulation of the neurohypophysis and by their characteristic high frequency discharge of action potentials approximately 15-20 s before reflex milk ejection. Acetylcholine (ACh) excited the majority (75%) of paraventricular oxytocinergic neurones, and none of the cells was inhibited in its activity by ACh. In about half of the oxytocinergic cells, atropine and hexamethonium reduced the number of action potentials during the burst discharge preceding reflex milk ejection. Noradrenaline (NE), dopamine (DA) and serotonin (5-HT) reduced the activity of most (75-100%) of oxytocinergic neurones, and none of the cells was excited by these catecholamines. 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subjects | Acetylcholine - pharmacology Action Potentials - drug effects Animals Atropine - pharmacology Biological and medical sciences Dopamine - pharmacology Female Fundamental and applied biological sciences. Psychology Hexamethonium Hexamethonium Compounds - pharmacology Hormone metabolism and regulation Lactation - drug effects Norepinephrine - pharmacology Oxytocin - physiology Paraventricular Hypothalamic Nucleus - drug effects Paraventricular Hypothalamic Nucleus - physiology Pregnancy Pregnancy. Parturition. Lactation Rats Serotonin - pharmacology Vertebrates: reproduction |
title | Effect of Microelectrophoretically Applied Acetylcholine, Noradrenaline, Dopamine and Serotonin on the Discharge of Paraventricular Oxytocinergic Neurones in the Rat |
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