Beta-cell hypersensitivity for glucose precedes loss of glucose-induced insulin secretion in 90% pancreatectomized rats

Glucose-induced insulin secretion is impaired in the presence of chronic hyperglycaemia. Insulin secretion was studied in a diabetic rat model prior to the beta cells becoming non-responsive to glucose in order to map out the sequence of changes that accompany chronic hyperglycaemia. In vitro pancre...

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Veröffentlicht in:	Diabetologia 1993-12, Vol.36 (12), p.1238-1244
Hauptverfasser:	LEAHY, J. L, BUMBALO, L. M, CHEN, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blood Glucose - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Glucose - pharmacology In Vitro Techniques Insulin - pharmacology Islets of Langerhans - drug effects Islets of Langerhans - metabolism Kinetics Male Medical sciences Pancreatectomy Perfusion Rats Rats, Sprague-Dawley Time Factors
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