Radioimmunodetection of Head and Neck Cancer: A Review
Radiolabeled antibodies can add a dimension in the diagnostic imaging and staging of metastatic head and neck malignancies. In the oral cavity, oropharynx and larynx the vast majority of malignancies are squamous cell carcinomas. This common cellular origin makes it feasible to search these neoplasm...
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| Veröffentlicht in: | Acta oncologica 1993, Vol.32 (7-8), p.735-740 |
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| container_end_page | 740 |
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| container_issue | 7-8 |
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| container_title | Acta oncologica |
| container_volume | 32 |
| creator | Hopsu, Erkki V. M. Kairemo, Kalevi J. A. |
| description | Radiolabeled antibodies can add a dimension in the diagnostic imaging and staging of metastatic head and neck malignancies. In the oral cavity, oropharynx and larynx the vast majority of malignancies are squamous cell carcinomas. This common cellular origin makes it feasible to search these neoplasms for appropriate tumor-associated antigens which can be used for radioimmunoscintigraphy. The pretherapeutic staging of head and neck malignancies, including salivary gland tumors, is based on clinical findings and conventional radiology (computerized tomography, magnetic resonance imaging, ultrasonography). The routine use of monoclonal antibodies for imaging head and neck malignancies was made possible by the production of several monoclonal antibodies to tumor-associated membrane antigens. A review of the clinical trials reported in the literature, and our own results with 111In-labeled anti-carcinoembryonic antigen (CEA) antibody in 42 patients are presented. |
| doi_str_mv | 10.3109/02841869309096129 |
| format | Article |
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M.</creatorcontrib><creatorcontrib>Kairemo, Kalevi J. A.</creatorcontrib><title>Radioimmunodetection of Head and Neck Cancer: A Review</title><title>Acta oncologica</title><addtitle>Acta Oncol</addtitle><description>Radiolabeled antibodies can add a dimension in the diagnostic imaging and staging of metastatic head and neck malignancies. In the oral cavity, oropharynx and larynx the vast majority of malignancies are squamous cell carcinomas. This common cellular origin makes it feasible to search these neoplasms for appropriate tumor-associated antigens which can be used for radioimmunoscintigraphy. The pretherapeutic staging of head and neck malignancies, including salivary gland tumors, is based on clinical findings and conventional radiology (computerized tomography, magnetic resonance imaging, ultrasonography). The routine use of monoclonal antibodies for imaging head and neck malignancies was made possible by the production of several monoclonal antibodies to tumor-associated membrane antigens. A review of the clinical trials reported in the literature, and our own results with 111In-labeled anti-carcinoembryonic antigen (CEA) antibody in 42 patients are presented.</description><subject>Animals</subject><subject>Antibodies, Monoclonal</subject><subject>Biological and medical sciences</subject><subject>Carcinoembryonic Antigen - immunology</subject><subject>Carcinoma, Small Cell - diagnostic imaging</subject><subject>Clinical Trials as Topic</subject><subject>Ent. Stomatology</subject><subject>Head and Neck Neoplasms - diagnostic imaging</subject><subject>Humans</subject><subject>Indium Radioisotopes</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Medical sciences</subject><subject>Radioimmunodetection</subject><subject>Radionuclide investigations</subject><issn>0284-186X</issn><issn>1651-226X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFLwzAYhoMoc05_gAehB_FW_ZKsSaOnMdQJQ2Eo7FbS9AvrbJuZtIr_3o4NL4Kn7_A-78vHQ8g5hWtOQd0AS8c0FYqDAiUoUwdkSEVCY8bE8pAMt3ncA8tjchLCGgAYl8mADFIOCWMwJGKhi9KVdd01rsAWTVu6JnI2mqEuIt0U0TOa92iqG4P-NppEC_ws8euUHFldBTzb3xF5e7h_nc7i-cvj03Qyjw2Xso0ZIIq0UMxIlWAuNGqQFM3YUkWTwkCSp8YKKZSRTNtcWAqCy3GqFc-NYHxErna7G-8-OgxtVpfBYFXpBl0XMikYJEKJHqQ70HgXgkebbXxZa_-dUci2rrI_rvrOxX68y2ssfht7OX1-uc91MLqyvpdQhl-MK5CSjnvsboeVjXW-1ivUVbsy2mO2dp1vej__PPEDm9qBgQ</recordid><startdate>1993</startdate><enddate>1993</enddate><creator>Hopsu, Erkki V. 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| fulltext | fulltext |
| identifier | ISSN: 0284-186X |
| ispartof | Acta oncologica, 1993, Vol.32 (7-8), p.735-740 |
| issn | 0284-186X 1651-226X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76205696 |
| source | MEDLINE; Taylor & Francis:Master (3349 titles); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Antibodies, Monoclonal Biological and medical sciences Carcinoembryonic Antigen - immunology Carcinoma, Small Cell - diagnostic imaging Clinical Trials as Topic Ent. Stomatology Head and Neck Neoplasms - diagnostic imaging Humans Indium Radioisotopes Investigative techniques, diagnostic techniques (general aspects) Medical sciences Radioimmunodetection Radionuclide investigations |
| title | Radioimmunodetection of Head and Neck Cancer: A Review |
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