Cyclopentenyl cytidine analogue: an inhibitor of cytidine triphosphate synthesis in human colon carcinoma cells

The mechanism of action of the cyclopentenyl analogue of cytidine, cCyd, was investigated in human colon carcinoma cell line HT-29. Upon exposure of cells to 10(-6)M cCyd, cell viability was reduced to 20% of control, whereas cytocidal activity was not present after 2 hr of drug exposure. Cell letha...

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Veröffentlicht in:	Biochemical pharmacology 1985-07, Vol.34 (14), p.2535-2539
Hauptverfasser:	GLAZER, R. I, KNODE, M. C, MU-ILL LIM, MARQUEZ, V. E
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Cell Line Cell Survival - drug effects Colonic Neoplasms - metabolism Cytidine - analogs & derivatives Cytidine - pharmacology Cytidine Triphosphate - biosynthesis Cytosine Nucleotides - biosynthesis DNA, Neoplasm - biosynthesis General aspects Humans Medical sciences Pharmacology. Drug treatments RNA, Neoplasm - biosynthesis Uridine - analogs & derivatives
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